3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product Name: 3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.: 330785-90-5
Chemical Name: 3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms: BTK ligand 1;Ibrutinib Impurity 45;N-piperidine Ibrutinib;Ibrutinib Impurity ZY3;N piperidine Ibrutinib,Npiperidine Ibrutinib;3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(4-piperidinyl)-
CBNumber: CB83158748
Molecular Formula: C22H22N6O
Formula Weight: 386.45
MOL File: 330785-90-5.mol

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3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Property

Boiling point:: 626.3±55.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
pka: 9.63±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemical Properties,Usage,Production

Uses

BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk). BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies[1].

References

[1] Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575. DOI:10.1021/acs.biochem.8b00391

3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Suppliers

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330785-90-5, 3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineRelated Search:

4-PHENOXYBENZOYL CHLORIDE (S)-3-(4-phenoxyphenyl)-1-(piperidin-3-yl) 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine

3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-1-(4-piperidinyl)-

Ibrutinib Impurity 45

N-piperidine Ibrutinib

N piperidine Ibrutinib,Npiperidine Ibrutinib

BTK ligand 1

Ibrutinib Impurity ZY3

330785-90-5