m-PEG3-Sulfone-PEG3-azide
- Product Name
- m-PEG3-Sulfone-PEG3-azide
- CAS No.
- 1895922-76-5
- Chemical Name
- m-PEG3-Sulfone-PEG3-azide
- Synonyms
- mPEG3-Sulfone-PEG3-N3;m-PEG3-Sulfone-PEG3-azide
- CBNumber
- CB83163014
- Molecular Formula
- C15H31N3O8S
- Formula Weight
- 413.48694
- MOL File
- 1895922-76-5.mol
N-Bromosuccinimide Price
- Product number
- BP-23173
- Product name
- m-PEG3-Sulfone-PEG3-azide
- Purity
- 98%
- Packaging
- 100mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- BP-23173
- Product name
- m-PEG3-Sulfone-PEG3-azide
- Purity
- 98%
- Packaging
- 250mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- BP-23173
- Product name
- m-PEG3-Sulfone-PEG3-azide
- Purity
- 98%
- Packaging
- 500mg
- Price
- $690
- Updated
- 2021/12/16
- Product number
- BP-23173
- Product name
- m-PEG3-Sulfone-PEG3-azide
- Purity
- 98%
- Packaging
- 1g
- Price
- $980
- Updated
- 2021/12/16
m-PEG3-Sulfone-PEG3-azide Chemical Properties,Usage,Production
Description
m-PEG3-Sulfone-PEG3-azide PEG linker containing sulfone and azide moieties. The sulfone can react with thiol groups of proteins. The azide can react with alkynes, DBCO and BCN for copper-catalyzed Click Chemistry reactions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Uses
m-PEG3-Sulfone-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG3-Sulfone-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
m-PEG3-Sulfone-PEG3-azide Preparation Products And Raw materials
Raw materials
Preparation Products
m-PEG3-Sulfone-PEG3-azide Suppliers
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View Lastest Price from m-PEG3-Sulfone-PEG3-azide manufacturers
- Product
- m-PEG3-Sulfone-PEG3-azide 1895922-76-5
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >95.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-28