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URB754

Product Name
URB754
CAS No.
86672-58-4
Chemical Name
URB754
Synonyms
URB754;CS-1952;URB754, >=98%;URB754,URB-754;URB754;URB 754;URB-754;URB754, Monoacylglycerol lipase inhibitor;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one;6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one >6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one
CBNumber
CB8323934
Molecular Formula
C16H14N2O2
Formula Weight
266.3
MOL File
86672-58-4.mol
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URB754 Property

Melting point:
238-240°C
Boiling point:
434.0±48.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
3.76±0.20(Predicted)
form 
Off-white solid.
color 
White to Off-White
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Safety

HS Code 
2934.99.4400
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2572
Product name
6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
Purity
>95.0%(HPLC)
Packaging
10mg
Price
$75
Updated
2024/03/01
TCI Chemical
Product number
M2572
Product name
6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
Purity
>95.0%(HPLC)
Packaging
50mg
Price
$258
Updated
2024/03/01
Cayman Chemical
Product number
10007691
Product name
URB754
Purity
>98%
Packaging
5mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
10007691
Product name
URB754
Purity
>98%
Packaging
10mg
Price
$66
Updated
2024/03/01
Cayman Chemical
Product number
10007691
Product name
URB754
Purity
>98%
Packaging
50mg
Price
$274
Updated
2024/03/01
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URB754 Chemical Properties,Usage,Production

Description

URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. There is evidence that the MAGL inhibitory activity of URB754 may be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial preparations. URB754 inhibits rat brain fatty acyl amide hydrolase (FAAH) with an IC50 value of 32 μM and binds weakly to the rat central cannabinoid (CB1) receptor with an IC50 value of 3.8 μM. It does not inhibit COX-1 or COX-2 at concentrations up to 100 μM. Inhibition of MAGL hydrolysis of 2-arachidonoyl glycerol (2-AG) is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

Chemical Properties

Off-White Solid

Uses

URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 μM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 μM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 μM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

URB754 Preparation Products And Raw materials

Raw materials

Preparation Products

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URB754 Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
13901585132
Fax
+86-25-52131256
Email
799750417@qq.com
Country
China
ProdList
8878
Advantage
55
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View Lastest Price from URB754 manufacturers

Career Henan Chemical Co
Product
URB754 86672-58-4
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18
Career Henan Chemical Co
Product
URB754 86672-58-4
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

86672-58-4, URB754Related Search:


  • URB754
  • 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one
  • 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
  • 6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one
  • 6-Methyl-2-(p-tolylaMino)-1H-benzo[d][1,3]oxazin-4(2H)-one
  • 6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one
  • 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
  • URB754, >=98%
  • 6-Methyl-2-(<i>p</i>-tolylamino)-4<i>H</i>-3,1-benzoxazin-4-one
  • CS-1952
  • URB754;URB 754;URB-754
  • 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one &gt
  • 4H-3,1-Benzoxazin-4-one, 6-methyl-2-[(4-methylphenyl)amino]-
  • URB754,URB-754
  • URB754, Monoacylglycerol lipase inhibitor
  • 86672-58-4
  • URB754 is a potent, noncompetitive inhibitor of MGL.
  • Chemical for Research
  • All Inhibitors
  • Inhibitors
  • Aromatics
  • Heterocycles
  • Research Chemical