URB754
- Product Name
- URB754
- CAS No.
- 86672-58-4
- Chemical Name
- URB754
- Synonyms
- URB754;CS-1952;URB754, >=98%;URB754,URB-754;URB754;URB 754;URB-754;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one;6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one >6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylaMino)-1H-benzo[d][1,3]oxazin-4(2H)-one
- CBNumber
- CB8323934
- Molecular Formula
- C16H14N2O2
- Formula Weight
- 266.3
- MOL File
- 86672-58-4.mol
URB754 Property
- Melting point:
- 238-240°C
- Boiling point:
- 434.0±48.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- pka
- 3.76±0.20(Predicted)
- form
- Off-white solid.
- color
- White to Off-White
Safety
- HS Code
- 2934.99.4400
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M2572
- Product name
- 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
- Purity
- >95.0%(HPLC)
- Packaging
- 10mg
- Price
- $75
- Updated
- 2024/03/01
- Product number
- M2572
- Product name
- 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
- Purity
- >95.0%(HPLC)
- Packaging
- 50mg
- Price
- $258
- Updated
- 2024/03/01
- Product number
- 10007691
- Product name
- URB754
- Purity
- >98%
- Packaging
- 5mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 10007691
- Product name
- URB754
- Purity
- >98%
- Packaging
- 10mg
- Price
- $66
- Updated
- 2024/03/01
- Product number
- 10007691
- Product name
- URB754
- Purity
- >98%
- Packaging
- 50mg
- Price
- $274
- Updated
- 2024/03/01
URB754 Chemical Properties,Usage,Production
Description
URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. There is evidence that the MAGL inhibitory activity of URB754 may be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial preparations. URB754 inhibits rat brain fatty acyl amide hydrolase (FAAH) with an IC50 value of 32 μM and binds weakly to the rat central cannabinoid (CB1) receptor with an IC50 value of 3.8 μM. It does not inhibit COX-1 or COX-2 at concentrations up to 100 μM. Inhibition of MAGL hydrolysis of 2-arachidonoyl glycerol (2-AG) is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
Chemical Properties
Off-White Solid
Uses
URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 and binds weakly to the rat CB1 r
Uses
URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 μM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 μM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 μM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
URB754 Preparation Products And Raw materials
Raw materials
Preparation Products
URB754 Suppliers
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View Lastest Price from URB754 manufacturers
- Product
- URB754 86672-58-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18
- Product
- URB754 86672-58-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18