URB754

ChemicalBook > CAS DataBase List > URB754

Product Name: URB754
CAS No.: 86672-58-4
Chemical Name: URB754
Synonyms: URB754;CS-1952;URB754, >=98%;URB754,URB-754;URB754;URB 754;URB-754;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one;6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one >6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylaMino)-1H-benzo[d][1,3]oxazin-4(2H)-one
CBNumber: CB8323934
Molecular Formula: C16H14N2O2
Formula Weight: 266.3
MOL File: 86672-58-4.mol

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URB754 Property

Melting point:: 238-240°C
Boiling point:: 434.0±48.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: 3.76±0.20(Predicted)
form: Off-white solid.
color: White to Off-White

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Safety

HS Code: 2934.99.4400

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2572
Product name: 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
Purity: >95.0%(HPLC)
Packaging: 10mg
Price: $75
Updated: 2024/03/01

TCI Chemical

Product number: M2572
Product name: 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
Purity: >95.0%(HPLC)
Packaging: 50mg
Price: $258
Updated: 2024/03/01

Cayman Chemical

Product number: 10007691
Product name: URB754
Purity: >98%
Packaging: 5mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 10007691
Product name: URB754
Purity: >98%
Packaging: 10mg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 10007691
Product name: URB754
Purity: >98%
Packaging: 50mg
Price: $274
Updated: 2024/03/01

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URB754 Chemical Properties,Usage,Production

Description

URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC₅₀ value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. There is evidence that the MAGL inhibitory activity of URB754 may be attributed to the impurity bis(methylthio)mercurane (IC₅₀ = 11.9 nM for rat recombinant MAGL) that is found in commercial preparations. URB754 inhibits rat brain fatty acyl amide hydrolase (FAAH) with an IC₅₀ value of 32 μM and binds weakly to the rat central cannabinoid (CB₁) receptor with an IC₅₀ value of 3.8 μM. It does not inhibit COX-1 or COX-2 at concentrations up to 100 μM. Inhibition of MAGL hydrolysis of 2-arachidonoyl glycerol (2-AG) is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

Chemical Properties

Off-White Solid

Uses

URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 μM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 μM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 μM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

URB754 Preparation Products And Raw materials

Raw materials

Preparation Products

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URB754 Suppliers

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View Lastest Price from URB754 manufacturers

Career Henan Chemical Co

Product: URB754 86672-58-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

Career Henan Chemical Co

Product: URB754 86672-58-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

86672-58-4, URB754Related Search:

N-Arachidonyl maleimide 2-AMINO-4H-BENZO[D][1,3]OXAZIN-4-ONE 6-METHYL-2-(PHENYLAMINO)-4H-3,1-BENZOXAZIN-4-ONE 4H-BENZO[D][1,3]OXAZIN-2-AMINE 2-Anilino-4H-3,1-benzoxazin-4-one URB754 N-2,4-DIMETHYLPHENYL-N'-METHYLFORMAMIDINE 4-[(6-METHYL-4-OXO-4H-3,1-BENZOXAZIN-2-YL)AMINO] BENZOIC ACID, BUTYL ESTER

URB754

6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one

6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one

6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one

6-Methyl-2-(p-tolylaMino)-1H-benzo[d][1,3]oxazin-4(2H)-one

6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one

6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one

URB754, >=98%

6-Methyl-2-(<i>p</i>-tolylamino)-4<i>H</i>-3,1-benzoxazin-4-one

CS-1952

URB754;URB 754;URB-754

6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one &gt

4H-3,1-Benzoxazin-4-one, 6-methyl-2-[(4-methylphenyl)amino]-

URB754,URB-754

86672-58-4

URB754 is a potent, noncompetitive inhibitor of MGL.

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