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URB754

Product Name
URB754
CAS No.
86672-58-4
Chemical Name
URB754
Synonyms
URB754;CS-1952;URB754, >=98%;URB754,URB-754;URB754;URB 754;URB-754;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one;6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one >6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one;6-Methyl-2-(p-tolylaMino)-1H-benzo[d][1,3]oxazin-4(2H)-one
CBNumber
CB8323934
Molecular Formula
C16H14N2O2
Formula Weight
266.3
MOL File
86672-58-4.mol
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URB754 Property

Melting point:
238-240°C
Boiling point:
434.0±48.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
3.76±0.20(Predicted)
form 
Off-white solid.
color 
White to Off-White
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Safety

HS Code 
2934.99.4400
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M2572
Product name
6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
Purity
>95.0%(HPLC)
Packaging
10mg
Price
$75
Updated
2024/03/01
TCI Chemical
Product number
M2572
Product name
6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
Purity
>95.0%(HPLC)
Packaging
50mg
Price
$258
Updated
2024/03/01
Cayman Chemical
Product number
10007691
Product name
URB754
Purity
>98%
Packaging
5mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
10007691
Product name
URB754
Purity
>98%
Packaging
10mg
Price
$66
Updated
2024/03/01
Cayman Chemical
Product number
10007691
Product name
URB754
Purity
>98%
Packaging
50mg
Price
$274
Updated
2024/03/01
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URB754 Chemical Properties,Usage,Production

Description

URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. There is evidence that the MAGL inhibitory activity of URB754 may be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial preparations. URB754 inhibits rat brain fatty acyl amide hydrolase (FAAH) with an IC50 value of 32 μM and binds weakly to the rat central cannabinoid (CB1) receptor with an IC50 value of 3.8 μM. It does not inhibit COX-1 or COX-2 at concentrations up to 100 μM. Inhibition of MAGL hydrolysis of 2-arachidonoyl glycerol (2-AG) is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

Chemical Properties

Off-White Solid

Uses

URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 μM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 μM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 μM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

URB754 Preparation Products And Raw materials

Raw materials

Preparation Products

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URB754 Suppliers

Americas 1 Canada 1 China 63 Europe 1 Germany 2 India 2 Japan 1 United States 11 Global 82
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from URB754 manufacturers

Career Henan Chemical Co
Product
URB754 86672-58-4
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18
Career Henan Chemical Co
Product
URB754 86672-58-4
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

86672-58-4, URB754Related Search:

N-Arachidonyl maleimide 2-AMINO-4H-BENZO[D][1,3]OXAZIN-4-ONE 6-METHYL-2-(PHENYLAMINO)-4H-3,1-BENZOXAZIN-4-ONE 4H-BENZO[D][1,3]OXAZIN-2-AMINE 2-Anilino-4H-3,1-benzoxazin-4-one URB754 N-2,4-DIMETHYLPHENYL-N'-METHYLFORMAMIDINE 4-[(6-METHYL-4-OXO-4H-3,1-BENZOXAZIN-2-YL)AMINO] BENZOIC ACID, BUTYL ESTER

  • URB754
  • 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one
  • 6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
  • 6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one
  • 6-Methyl-2-(p-tolylaMino)-1H-benzo[d][1,3]oxazin-4(2H)-one
  • 6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one
  • 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
  • URB754, >=98%
  • 6-Methyl-2-(<i>p</i>-tolylamino)-4<i>H</i>-3,1-benzoxazin-4-one
  • CS-1952
  • URB754;URB 754;URB-754
  • 6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one &gt
  • 4H-3,1-Benzoxazin-4-one, 6-methyl-2-[(4-methylphenyl)amino]-
  • URB754,URB-754
  • 86672-58-4
  • URB754 is a potent, noncompetitive inhibitor of MGL.
  • Chemical for Research
  • All Inhibitors
  • Inhibitors
  • Aromatics
  • Heterocycles
  • Research Chemical