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Nifekalant hydrochloride

Product Name
Nifekalant hydrochloride
CAS No.
130656-51-8
Chemical Name
Nifekalant hydrochloride
Synonyms
ms551;Shinbit;NIFEKALANT HCL;NIFEKALANT HYDROCHLORIDE;Nifekalant 130636-43-0 /;Nifekalant hydrochloride (MS-551);Nifekalant hydrochloride USP/EP/BP;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride;1,3-Dimethyl-6-((2-(N-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino)-2,4(1H),3H)-pyrimidinedione HCl;1,3-Dimethyl-6-[2-(N-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino]-2,4(1H,3H)-pyrimidinedione hydrochloride
CBNumber
CB8325413
Molecular Formula
C19H28ClN5O5
Formula Weight
441.91
MOL File
130656-51-8.mol
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Nifekalant hydrochloride Property

Melting point:
172-174°
storage temp. 
Refrigerator
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly)
form 
Solid
pka
7.05(at 25℃)
color 
Light Yellow to Yellow
CAS DataBase Reference
130656-51-8(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20997
Product name
Nifekalant (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20997
Product name
Nifekalant (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
20997
Product name
Nifekalant (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
20997
Product name
Nifekalant (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$243
Updated
2024/03/01
TRC
Product number
N457100
Product name
NifekalantHydrochloride
Packaging
1g
Price
$1165
Updated
2021/12/16
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Nifekalant hydrochloride Chemical Properties,Usage,Production

Description

Nifekalant is a novel and pure class III anti-arrhythmic agent introduced in Japan as Shinbit injection for the treatment of serious ventricular arrhythmias. It can be synthesized in 3 steps with a final assembly of two ethanolamine blocks. Nifekalant is a non-selective blocker of myocardial repolarizing potassium currents and is completely devoid of any β-adrenergic blocking effect . In hearts from different species, Nifekalant significantly prolonged action potential duration, atrial and ventricular refractory periods in in situ and in isolation studies. In intact animals, hemodynamic parameters were not affected by doses up to 1 mg/kg. The specific characteristics of its voltage- and timedependent K+ current blockade might differentiate Nifekalant from other class III agents currently in use.

Description

Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials. It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 μM). Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 μM).

Chemical Properties

Yellow Solid

Originator

Mitsui (Japan)

Uses

Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.

Definition

ChEBI: Nifekalant hydrochloride is an amine. It contains a Nifekalant.

brand name

Shinbit

Nifekalant hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Nifekalant hydrochloride manufacturers

Career Henan Chemical Co
Product
Nifekalant hydrochloride 130656-51-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-11

130656-51-8, Nifekalant hydrochloride Related Search:

Topotecan hydrochloride Dimethyl fumarate 2-(METHYLSULFONYL)ETHANOL Dacthal Dimethyl ether Dimethyl sulfate DIMETHYLAMINOPYRIDINE, POLYMER-BOUND N,N-Dimethyl-1,4-phenylenediamine ETHANE Lithium diisopropylamide N,N-Dimethylformamide Dimethyl sulfoxide Dimethylcarbamoyl chloride N,N-Diisopropylethylamine Dimethyl carbonate Dimethyl disulfide Nifekalant 2-METHYLPENTANE

  • 1,3-Dimethyl-6-[2-(N-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino]-2,4(1H,3H)-pyrimidinedione hydrochloride
  • Nifekalant 130636-43-0 /
  • 1,3-Dimethyl-6-((2-(N-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino)-2,4(1H),3H)-pyrimidinedione HCl
  • 2,4(1H,3H)-Pyrimidinedione, 6-((2-((2-hydroxyethyl)(3-(4-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethyl-, monohydrochloride
  • 6-[[2-[(2-Hydroxyethyl)[3-(4-nitrophenyl)propyl]aMino]ethyl]aMino]-1,3-diMethyl-2,4(1H,3H)-pyriMidinedione Hydrochloride
  • Shinbit
  • ms551
  • NIFEKALANT HYDROCHLORIDE
  • NIFEKALANT HCL
  • 6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride
  • Nifekalant hydrochloride USP/EP/BP
  • Nifekalant hydrochloride (MS-551)
  • 130656-51-8
  • C19H27N5O5HCl
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  • Aromatics
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