5-Chloro-6-fluoro-1H-indole
Application- Product Name
- 5-Chloro-6-fluoro-1H-indole
- CAS No.
- 169674-57-1
- Chemical Name
- 5-Chloro-6-fluoro-1H-indole
- Synonyms
- 5-CHLORO-6-FLUOROINDOLE;5-chloro-6-fluoro-1H-indole;1H-Indole, 5-chloro-6-fluoro-;5-Chloro-6-fluoro-1H-indole 97%
- CBNumber
- CB8328308
- Molecular Formula
- C8H5ClFN
- Formula Weight
- 169.58
- MOL File
- 169674-57-1.mol
5-Chloro-6-fluoro-1H-indole Property
- Melting point:
- 83 °C
- Boiling point:
- 299.8±20.0 °C(Predicted)
- Density
- 1.436±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 15.49±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C368588
- Product name
- 5-Chloro-6-fluoro-1H-indole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C368588
- Product name
- 5-Chloro-6-fluoro-1H-indole
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- PC9933
- Product name
- 5-Chloro-6-fluoro-1H-indole
- Purity
- 97%
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 3H31-7-X8
- Product name
- 5-Chloro-6-fluoroindole
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 119082
- Product name
- 5-Chloro-6-fluoro-1H-indole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
5-Chloro-6-fluoro-1H-indole Chemical Properties,Usage,Production
Application
5-Chloro-6-fluoroindole can be used as a pharmaceutical synthesis intermediate.
Synthesis
1097107-68-0
169674-57-1
General procedure for the synthesis of 5-chloro-6-fluoroindole from methyl (4-chloro-5-fluoro-2-((trimethylsilyl)ethynyl)phenyl)carbamate: dissolve the crude (4-chloro-5-fluoro-2-trimethylsilylethynylphenyl)carbamate methyl ester (ca. 21 mmol) in tetrahydrofuran (200 mL) and add tetrabutylammonium fluoride (43.3 mL, 1 M in tetrahydrofuran, 43.3 mmol). The reaction was carried out at room temperature. After stirring for 5 minutes, the reaction mixture was refluxed for 1 hour under argon protection. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The resulting oil was treated with water (55 mL), stirred for 10 minutes and subsequently extracted twice with ethyl acetate (100 mL). The combined organic phases were washed sequentially with 1 M aqueous hydrochloric acid (50 mL), saturated aqueous sodium bicarbonate (50 mL), and saturated aqueous sodium chloride (50 mL), and finally dried with magnesium sulfate. The dried organic phase was filtered and concentrated under reduced pressure. The residue was stirred with hexane (200 mL) under reflux, cooled to 5 °C and filtered to afford 5-chloro-6-fluoro-1H-indole (3.15 g, 85% yield) as a light brown solid. Mass spectrometry (EI) showed a molecular ion peak m/z 169.1 (M+).
References
[1] Patent: US2007/185182, 2007, A1. Location in patent: Page/Page column 12
[2] Patent: US2006/30613, 2006, A1. Location in patent: Page/Page column 30
5-Chloro-6-fluoro-1H-indole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Chloro-6-fluoro-1H-indole manufacturers
- Product
- 5-CHLORO-6-FLUOROINDOLE 169674-57-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-CHLORO-6-FLUOROINDOLE 169674-57-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 5-CHLORO-6-FLUOROINDOLE 169674-57-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19