Uses
ChemicalBook > CAS DataBase List > 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE

4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE

Uses
Product Name
4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE
CAS No.
1701-24-2
Chemical Name
4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE
Synonyms
BUTTPARK 29\04-05;2-TrifluoroMethyl-4-chloroquinoline;4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE;Quinoline, 4-chloro-2-(trifluoromethyl)-;4-Chloro-2-(trifluoromethyl)quinoline97%;4-Chloro-2-(trifluoromethyl)quinoline 97%;JR-8171, 4-Chloro-2-(trifluoromethyl)quinoline, 97%;4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE ISO 9001：2015 REACH
CBNumber
CB8334196
Molecular Formula
C10H5ClF3N
Formula Weight
231.6
MOL File
1701-24-2.mol
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4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE Property

Melting point:
34-38 °C
Boiling point:
236.4±35.0 °C(Predicted)
Density 
1.427±0.06 g/cm3(Predicted)
Flash point:
225°C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
powder to lump to clear liquid
pka
-1.19±0.50(Predicted)
color 
White or Colorless to Almost white or Almost colorless
InChI
1S/C10H5ClF3N/c11-7-5-9(10(12,13)14)15-8-4-2-1-3-6(7)8/h1-5H
InChIKey
ONNDFDQMHCNEGF-UHFFFAOYSA-N
SMILES
FC(F)(F)c1cc(Cl)c2ccccc2n1
CAS DataBase Reference
1701-24-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933499090
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
681946
Product name
4-Chloro-2-(trifluoromethyl)quinoline
Purity
97%
Packaging
1g
Price
$64.1
Updated
2023/06/20
Sigma-Aldrich
Product number
681946
Product name
4-Chloro-2-(trifluoromethyl)quinoline
Purity
97%
Packaging
5g
Price
$185
Updated
2023/01/07
TCI Chemical
Product number
C3262
Product name
4-Chloro-2-(trifluoromethyl)quinoline
Purity
min. 97.0 %
Packaging
1G
Price
$51
Updated
2025/07/31
TCI Chemical
Product number
C3262
Product name
4-Chloro-2-(trifluoromethyl)quinoline
Purity
min. 97.0 %
Packaging
5G
Price
$153
Updated
2025/07/31
TRC
Product number
C432995
Product name
4-Chloro-2-(trifluoromethyl)quinoline
Packaging
1g
Price
$75
Updated
2021/12/16
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4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE Chemical Properties,Usage,Production

Uses

4-Chloro-2-(trifluoromethyl)quinoline is a pharmaceutical intermediate that can be used to prepare N-(4-nitrophenylethyl)-2-(trifluoromethyl)quinoline-4-amine, a STAT3 inhibitor.

Synthesis

4-Chloro-2-(trifluoromethyl)quinoline (100.0 mg, 0.43 mmol), 2-(4-nitrophenyl)ethan-1-amine hydrochloride (87.0 mg, 0.43 mmol) and Et3N (180.0 ??L, 1.29 mmol) were added to NMP (1.0 mL). The reaction mixture was allowed to react in a microwave oven (50 W, at 100 ??C) for 1 h and then cooled to room temperature. After adding ice water, the reaction mixture was extracted with CH2Cl2. The organic layer was washed with brine, dried with Na2SO4 and filtered. The residue obtained under reduced pressure was purified by supercolumn chromatography on an amine silica column (CH2Cl2:MeOH = 20:1). The grades containing the product were collected and evaporated to give the white solid compound, N-(4-nitrophenylethyl)-2-(trifluoromethyl)quinolin-4-amine (35.0 mg, 23%).

4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE Suppliers

Belgium 1 China 85 Europe 2 France 1 Germany 2 India 9 Japan 1 Switzerland 2 Ukraine 2 United Kingdom 12 United States 30 Global 147
J & K SCIENTIFIC LTD.
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021-67582001/03/05
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Syntechem Co.,Ltd
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1701-24-2, 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINERelated Search:

6-(BROMOMETHYL)-4-CHLORO-2-(TRIFLUOROMETHYL)-QUINOLINE 6-BROMO-4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-6-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE 4,6-DICHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4,8-DICHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 4-CHLORO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-8-(TRIFLUOROMETHYL)QUINOLINE 4,7-DICHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-Chloro-6-(trifluoromethyl)quinoline 98%,4-Chloro-6-(trifluoromethyl)quinoline98%,4-CHLORO-6-(TRIFLUOROMETHYL)QUINOLINE 4-Bromo-7-chloro-2-(trifluoromethyl)quinoline 4-Bromo-8-chloro-2-(trifluoromethyl)quinoline 3-BROMO-4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-7-(TRIFLUOROMETHYL)QUINOLINE, 9 8%,4-Chloro-7-(trifluoromethyl)quinoline 98%,4-CHLORO-7-(TRIFLUOROMETHYL)QUINOLINE 4-BROMO-6-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE methyl 4-chloro-2-(trifluoromethyl)quinoline-6-carboxylate 4-CHLORO-6-METHYL-5-NITRO-2-(TRIFLUOROMETHYL)QUINOLINE

  • 2-TrifluoroMethyl-4-chloroquinoline
  • BUTTPARK 29\04-05
  • 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE
  • JR-8171, 4-Chloro-2-(trifluoromethyl)quinoline, 97%
  • 4-Chloro-2-(trifluoromethyl)quinoline 97%
  • 4-Chloro-2-(trifluoromethyl)quinoline97%
  • Quinoline, 4-chloro-2-(trifluoromethyl)-
  • 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE ISO 9001：2015 REACH
  • 1701-24-2
  • C10H5ClF3N
  • Halogenated Heterocycles
  • Quinolines
  • Heterocyclic Building Blocks
  • Building Blocks
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Quinolines
  • QuinolinesHeterocyclic Building Blocks
  • Quinoline&Isoquinoline