2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE

Product Name: 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE
CAS No.: 83012-13-9
Chemical Name: 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE
Synonyms: BUTTPARK 147\04-11;4-CHLORO-2,8-DI(TRIFLUOROMETHYL)QUINOLINE;4-Chloro-2,8-bis(trifluoromethyl)quinolone;4-CHLORO-2,8-BIS(TRIFLUOROMETHYL)QUINOLINE;2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE;2,8-Bis(trifluoromethyl)-4-chloroquinoline97%;Quinoline, 4-chloro-2,8-bis(trifluoromethyl)-;4-Chloro-2,8-bis(trifluoromethyl)quinoline,97%;4-CHLORO-2 8-BIS(TRIFLUOROMETHYL)QUINOLINE 97%;2,8-Bis(trifluoromethyl)-4-chloroquinoline 97%
CBNumber: CB0301493
Molecular Formula: C11H4ClF6N
Formula Weight: 299.6
MOL File: 83012-13-9.mol

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2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE Property

Melting point:: 46-48 °C (lit.)
Boiling point:: 148-152 °C(Press: 18 Torr)
Density: 1.5242 (estimate)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.49±0.50(Predicted)
form: Crystalline Powder
color: Beige
InChI: 1S/C11H4ClF6N/c12-7-4-8(11(16,17)18)19-9-5(7)2-1-3-6(9)10(13,14)15/h1-4H
InChIKey: ZSQOESPYYNJBCZ-UHFFFAOYSA-N
SMILES: FC(F)(F)c1cc(Cl)c2cccc(c2n1)C(F)(F)F
CAS DataBase Reference: 83012-13-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29334900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 337633
Product name: 4-Chloro-2,8-bis(trifluoromethyl)quinoline
Purity: 97%
Packaging: 1g
Price: $91.6
Updated: 2023/06/20

TRC

Product number: C381433
Product name: 4-Chloro-2,8-bis(trifluoromethyl)quinoline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: PC9012
Product name: 2,8-Bis(trifluoromethyl)-4-chloroquinoline
Purity: 97%
Packaging: 1g
Price: $28
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-7-W1
Product name: 2,8-Bis(trifluoromethyl)-4-chloroquinoline
Packaging: 1g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 005845
Product name: 2,8-Bis(trifluoromethyl)-4-chloroquinoline
Purity: 97%
Packaging: 1g
Price: $70
Updated: 2021/12/16

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2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE Chemical Properties,Usage,Production

Chemical Properties

beige crystalline powder

Uses

4-Chloro-2,8-bis(trifluoromethyl)quinolone is the intermediate formed during the synthesis of quinoline derivatives.

General Description

4-Chloro-2,8-bis(trifluoromethyl)quinolone is the intermediate formed during the synthesis of quinoline derivatives.

Synthesis

35853-41-9

83012-13-9

General procedure for the synthesis of 4-chloro-2,8-bis(trifluoromethyl)quinoline from 2,8-bis(trifluoromethyl)-4-hydroxyquinoline: 2,8-bis(trifluoromethyl)quinolin-4-ol (0.25 g, 0.89 mmol) was dissolved in phosphorus trichloride (5 mL) and the reaction was carried out at reflux for 5 h at 80 °C under nitrogen protection. Upon completion of the reaction, the reaction mixture was quenched with 30 mL of ice water and extracted with dichloromethane (2 x 20 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give a light yellow solid product (0.13 g, 50% yield), which could be used in subsequent reactions without further purification.

References

[1] Tetrahedron, 1991, vol. 47, # 36, p. 7609 - 7614
[2] European Journal of Medicinal Chemistry, 2010, vol. 45, # 8, p. 3374 - 3383
[3] Monatshefte fur Chemie, 2008, vol. 139, # 2, p. 179 - 181
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 23, p. 5466 - 5469
[5] Patent: US4429130, 1984, A

2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE Suppliers

Belgium 2 China 69 Europe 1 France 1 Germany 2 India 3 Japan 1 Switzerland 1 United Kingdom 10 United States 19 Global 109

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View Lastest Price from 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 83012-13-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-03

Henan Bao Enluo International TradeCo.，LTD

Product: 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 83012-13-9
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500t/month
Release date: 2023-08-18

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 83012-13-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-12

83012-13-9, 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINERelated Search:

8-Trifluoromethylquinoline 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-2,8-DIMETHYLQUINOLINE 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE 4-CHLORO-2-METHYL-8-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-2-METHYLQUINOLINE 4-CHLORO-8-(TRIFLUOROMETHYL)QUINOLINE 8-Methylquinoline 4-Chloroquinoline 4-Chloro-8-methylquinoline 2,8-Dimethylquinoline 2-(Trifluoromethyl)pyridine 8-METHYL-2-TRIFLUOROMETHYLQUINOLINE 4-CHLORO-6-PIPERIDIN-1-YL-PYRIMIDIN-2-YLAMINE 2-TRIFLUOROMETHYLQUINOLINE 2,6-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 5,7-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE

2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE

4-CHLORO-2,8-DI(TRIFLUOROMETHYL)QUINOLINE

4-CHLORO-2,8-BIS(TRIFLUOROMETHYL)QUINOLINE

BUTTPARK 147\04-11

4-Chloro-2,8-bis(trifluoromethyl)quinolone

2,8-Bis(trifluoromethyl)-4-chloroquinoline 97%

2,8-Bis(trifluoromethyl)-4-chloroquinoline97%

4-CHLORO-2 8-BIS(TRIFLUOROMETHYL)QUINOLINE 97%

4-Chloro-2,8-bis(trifluoromethyl)quinoline,97%

Quinoline, 4-chloro-2,8-bis(trifluoromethyl)-

2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE ISO 9001：2015 REACH

83012-13-9

C11H4ClF6N

Halogenated Heterocycles

Heterocyclic Building Blocks

Quinolines

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Quinoline&Isoquinoline

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Quinolines

QuinolinesHeterocyclic Building Blocks