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2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE

Product Name
2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE
CAS No.
131748-14-6
Chemical Name
2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE
Synonyms
4-CHLORO-2-(TRIFLUOROMETHYL)PYRIDINE;4-Chloro-2-(TrifluoroMeth;2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE;-chloro-2-(trifluoromethyl)pyridine;Pyridine,4-chloro-2-(trifluoromethyl)-;4-Chloro-2-(trifluoromethyl)pyridine 99%;4-Chloro-2-(trifluoromethyl)pyridine,98%;2-Trifluoromethyl-4-Chloropyridine(WX636118);4-Chloro-alpha,alpha,alpha-trifluoro-2-picoline;2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE ISO 9001：2015 REACH
CBNumber
CB0465418
Molecular Formula
C6H3ClF3N
Formula Weight
181.54
MOL File
131748-14-6.mol
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2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE Property

Boiling point:
137.4±35.0 °C(Predicted)
Density 
1.417
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.29±0.10(Predicted)
form 
Liquid
color 
Colorless
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C6H3ClF3N/c7-4-1-2-11-5(3-4)6(8,9)10/h1-3H
InChIKey
FZINIBTZNSPWQR-UHFFFAOYSA-N
SMILES
C1(C(F)(F)F)=NC=CC(Cl)=C1
CAS DataBase Reference
131748-14-6
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25-36
Safety Statements 
26-45
RIDADR 
UN2811
HazardClass 
IRRITANT
HazardClass 
6.1
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C432963
Product name
4-Chloro-2-(trifluoromethyl)pyridine
Packaging
100mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC01677
Product name
4-Chloro-2-(trifluoromethyl)pyridine
Purity
99%
Packaging
1g
Price
$15
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-7-94
Product name
4-Chloro-2-(trifluoromethyl)pyridine
Purity
97%
Packaging
1g
Price
$31
Updated
2021/12/16
Matrix Scientific
Product number
032511
Product name
4-Chloro-2-(trifluoromethyl)pyridine
Purity
97%
Packaging
1g
Price
$42
Updated
2021/12/16
Apolloscientific
Product number
PC01677
Product name
4-Chloro-2-(trifluoromethyl)pyridine
Purity
99%
Packaging
5g
Price
$48
Updated
2021/12/16
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2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE Chemical Properties,Usage,Production

Uses

Chloro(trifluoromethyl)pyridines derivatives are used as model substrates for regioexhaustive functionalization.

Synthesis

170886-13-2

131748-14-6

Example 1 Preparation of 4-chloro-2-trifluoromethylpyridine: In a 25 mL round-bottomed flask equipped with a reflux condenser, a magnetic stirrer, and vented with inert gas, 1.63 g (10.0 mmol) of 2-trifluoromethyl-4-hydroxypyridine was dissolved in a solvent mixture of 4.9 mL of cyclohexane and 0.077 mL of DMF. At room temperature, 2.19 mL (25.0 mmol) oxalyl chloride was slowly added. The reaction mixture was heated to reflux for 3 hours and subsequently cooled to room temperature. 18 mL of water was added slowly and dropwise (watch for gas release), then the reaction mixture was extracted with 18 mL of methyl tert-butyl ether (MTBE). The organic layer was separated, washed with 1 M sodium bicarbonate (NaHCO3) solution and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the solvent was evaporated under reduced pressure to give the crude product. The crude product was dissolved in 12 mL of hexane and stirred at room temperature for 5 min, filtered and evaporated under reduced pressure to give 0.9 g of 4-chloro-2-trifluoromethylpyridine as a yellow liquid. The product was analyzed by GC-EI-MS, showing molecular ion peaks at m/z 181 (M+) and m/z 183 (M+2).

References

[1] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00178
[2] Patent: WO2011/161612, 2011, A1. Location in patent: Page/Page column 13
[3] Patent: WO2014/76127, 2014, A1. Location in patent: Page/Page column 8
[4] Patent: WO2018/99812, 2018, A1. Location in patent: Page/Page column 70

2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE Suppliers

China 171 India 1 United Kingdom 4 United States 14 Global 190
Changzhou HCK Biotech Co., Ltd.
Tel
18796480679 15295163861
Email
3844328290@qq.com
Country
China
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
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China
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Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
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sales@chemwish.com
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China
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
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China
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Changzhou Huanling Chemical Co., Ltd.
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0519-89803565 13776850645
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0519-89803575
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info4@huanlingchem.com
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China
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
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sales@chemreagents.com
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United States
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Tetranov Biopharm
Tel
13526569071
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sales@leadmedpharm.com
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China
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Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
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China
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11035
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HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD
Tel
571-89189769 15168342188
Fax
0571-86205065
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China
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View Lastest Price from 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-Trifluoromethyl-4-chloropyridine 131748-14-6
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
Dideu Industries Group Limited
Product
2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE 131748-14-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-03
Career Henan Chemical Co
Product
2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE 131748-14-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-11

131748-14-6, 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINERelated Search:

4,8-DICHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4,6-DICHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 6-BROMO-4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 6-(BROMOMETHYL)-4-CHLORO-2-(TRIFLUOROMETHYL)-QUINOLINE 4-CHLORO-6-METHYL-2-(TRIFLUOROMETHYL)QUINOLINE Methyl 2-(4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)propanoate 3-TRIFLUOROMETHYL-5-CHLOROPYRIDINE METHYL 4-CHLORO-6-(TRIFLUOROMETHYL)THIENO[3,4-B]-PYRIDINE-1-CARBOXYLATE 4-CHLORO-6-(TRIFLUOROMETHOXY)-2-(TRIFLUOROMETHYL)QUINOLINE 8-BROMO-4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE ETHYL 4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-6-CARBOXYLATE 4-CHLORO-8-(TRIFLUOROMETHOXY)-2-(TRIFLUOROMETHYL)QUINOLINE 4,5,7-TRICHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-8-METHOXY-2-(TRIFLUOROMETHYL)QUINOLINE 4-CHLORO-6-METHYL-5-NITRO-2-(TRIFLUOROMETHYL)QUINOLINE

  • 4-Chloro-2-(trifluoromethyl)pyridine 99%
  • Pyridine,4-chloro-2-(trifluoromethyl)-
  • 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE
  • 4-CHLORO-2-(TRIFLUOROMETHYL)PYRIDINE
  • 4-Chloro-2-(TrifluoroMeth
  • 4-Chloro-alpha,alpha,alpha-trifluoro-2-picoline
  • 2-Trifluoromethyl-4-Chloropyridine(WX636118)
  • 4-Chloro-2-(trifluoromethyl)pyridine,98%
  • 2-TRIFLUOROMETHYL-4-CHLOROPYRIDINE ISO 9001：2015 REACH
  • -chloro-2-(trifluoromethyl)pyridine
  • 131748-14-6
  • Fluorine series
  • alkyl chloride