2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE
- Product Name
- 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE
- CAS No.
- 83012-13-9
- Chemical Name
- 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE
- Synonyms
- BUTTPARK 147\04-11;4-CHLORO-2,8-DI(TRIFLUOROMETHYL)QUINOLINE;4-Chloro-2,8-bis(trifluoromethyl)quinolone;4-CHLORO-2,8-BIS(TRIFLUOROMETHYL)QUINOLINE;2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE;2,8-Bis(trifluoromethyl)-4-chloroquinoline97%;Quinoline, 4-chloro-2,8-bis(trifluoromethyl)-;4-Chloro-2,8-bis(trifluoromethyl)quinoline,97%;4-CHLORO-2 8-BIS(TRIFLUOROMETHYL)QUINOLINE 97%;2,8-Bis(trifluoromethyl)-4-chloroquinoline 97%
- CBNumber
- CB0301493
- Molecular Formula
- C11H4ClF6N
- Formula Weight
- 299.6
- MOL File
- 83012-13-9.mol
2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE Property
- Melting point:
- 46-48 °C (lit.)
- Boiling point:
- 148-152 °C(Press: 18 Torr)
- Density
- 1.5242 (estimate)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.49±0.50(Predicted)
- form
- Crystalline Powder
- color
- Beige
- CAS DataBase Reference
- 83012-13-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 337633
- Product name
- 4-Chloro-2,8-bis(trifluoromethyl)quinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $91.6
- Updated
- 2023/06/20
- Product number
- C381433
- Product name
- 4-Chloro-2,8-bis(trifluoromethyl)quinoline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3H32-7-W1
- Product name
- 2,8-Bis(trifluoromethyl)-4-chloroquinoline
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 005845
- Product name
- 2,8-Bis(trifluoromethyl)-4-chloroquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- PC9012
- Product name
- 2,8-Bis(trifluoromethyl)-4-chloroquinoline
- Purity
- 97%
- Packaging
- 5g
- Price
- $113
- Updated
- 2021/12/16
2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE Chemical Properties,Usage,Production
Chemical Properties
beige crystalline powder
General Description
4-Chloro-2,8-bis(trifluoromethyl)quinolone is the intermediate formed during the synthesis of quinoline derivatives.
Synthesis
35853-41-9
83012-13-9
General procedure for the synthesis of 4-chloro-2,8-bis(trifluoromethyl)quinoline from 2,8-bis(trifluoromethyl)-4-hydroxyquinoline: 2,8-bis(trifluoromethyl)quinolin-4-ol (0.25 g, 0.89 mmol) was dissolved in phosphorus trichloride (5 mL) and the reaction was carried out at reflux for 5 h at 80 °C under nitrogen protection. Upon completion of the reaction, the reaction mixture was quenched with 30 mL of ice water and extracted with dichloromethane (2 x 20 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give a light yellow solid product (0.13 g, 50% yield), which could be used in subsequent reactions without further purification.
References
[1] Tetrahedron, 1991, vol. 47, # 36, p. 7609 - 7614
[2] European Journal of Medicinal Chemistry, 2010, vol. 45, # 8, p. 3374 - 3383
[3] Monatshefte fur Chemie, 2008, vol. 139, # 2, p. 179 - 181
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 23, p. 5466 - 5469
[5] Patent: US4429130, 1984, A
2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE Suppliers
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE manufacturers
- Product
- 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 83012-13-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-03
- Product
- 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 83012-13-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500t/month
- Release date
- 2023-08-18
- Product
- 2,8-BIS(TRIFLUOROMETHYL)-4-CHLOROQUINOLINE 83012-13-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-10-12