Autophinib

Product Name: Autophinib
CAS No.: 1644443-47-9
Chemical Name: Autophinib
Synonyms: CS-2834;Autophinib;Autophinib, 10 mM in DMSO;PI3K,inhibit,Autophagy,Autophinib,Phosphoinositide 3-kinase,Inhibitor;6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine;6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE;4-Pyrimidinamine, 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-
CBNumber: CB83344886
Molecular Formula: C14H11ClN6O3
Formula Weight: 346.73
MOL File: 1644443-47-9.mol

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Autophinib Property

Boiling point:: 640.6±65.0 °C(Predicted)
Density: 1.547±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:13.98(Max Conc. mg/mL);40.32(Max Conc. mM)
form: A solid
pka: 13.78±0.10(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2632
Product name: Autophinib
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $89.3
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML2632
Product name: Autophinib
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $361
Updated: 2022/05/15

Cayman Chemical

Product number: 27320
Product name: Autophinib
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27320
Product name: Autophinib
Packaging: 25mg
Price: $494
Updated: 2024/03/01

Cayman Chemical

Product number: 27320
Product name: Autophinib
Packaging: 5mg
Price: $139
Updated: 2024/03/01

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Autophinib Chemical Properties,Usage,Production

Uses

Autophinib is a potent VPS34 inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).

Biological Activity

Autophinib is an ATP-competitive, potent and selective PI3K type 3 lipid kinase vacuolar protein sorting 34 inhibitor (VPS34 IC50/[ATP] = 19 nM/10 μM & 51 nM/100 μM) th at shows significant inhibition against only 45 kinases among a panel of >460 with little or no potency toward mTOR, TBK1 and 12 other phosphatidylinositol kinases (=22% inhibition at 1 μM). Autophinib effectively prevents autophagy induction in MCF7 cells upon amino acid starvation or rapamycin treatment (IC50 = 40 nM and 19 nM, respectively) with similar potency as SAR405 (IC50 = 53 nM and 20 nM, respectively) and VPS34-IN1 (IC50 = 13 nM and 15 nM, respectively). Autophinib enhances MCF7 cell death under starvation condition (EC50 = 264 nM and 234 nM by cytotoxiciy and apoptosis detection, respectively) by preventing autophagy-dependent cell survival.

storage

Store at +4°C

Autophinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Autophinib Suppliers

China 60 India 1 United Kingdom 1 United States 10 Global 72

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
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MedChemexpress LLC

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ShangHai Caerulum Pharma Discovery Co., Ltd.

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghaizehan biopharma technology co., Ltd.

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Guangzhou Zhiya Chemdrugs Co.,Ltd

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Shanghai EFE Biological Technology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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Shanghai Rechem science Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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1644443-47-9, AutophinibRelated Search:

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Autophinib

6-CHLORO-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-(4-NITROPHENOXY)PYRIMIDIN-4-AMINE

6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine

CS-2834

4-Pyrimidinamine, 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-

PI3K,inhibit,Autophagy,Autophinib,Phosphoinositide 3-kinase,Inhibitor

Autophinib, 10 mM in DMSO

1644443-47-9