Labetalol hydrochloride

ChemicalBook > CAS DataBase List > Labetalol hydrochloride

Labetalol hydrochloride

Product Name: Labetalol hydrochloride
CAS No.: 32780-64-6
Chemical Name: Labetalol hydrochloride
Synonyms: LABETALOL HCL;normodyne;5-[1-HYDROXY-2-[(1-METHYL-3-PHENYLPROPYL)-AMINO]ETHYL]SALICYLAMIDE HYDROCHLORIDE;ipolab;labelol;ah5158a;amipress;Trandate;labrocol;presdate
CBNumber: CB8334888
Molecular Formula: C19H25ClN2O3
Formula Weight: 364.87
MOL File: 32780-64-6.mol

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Labetalol hydrochloride Property

Melting point:: 187-189°
storage temp.: 2-8°C
solubility: H₂O: soluble
form: powder
color: white

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: CV5376000
HS Code: 2924296000
Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 114, 120, 113, 107 i.p.; 47, 54, 60, 53 i.v.; 1450, 1800, 4550, 4000 orally (Shimpo)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L1011
Product name: Labetalol hydrochloride
Purity: >98% (TLC), powder
Packaging: 5g
Price: $109
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1356654
Product name: Labetalol hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 20249
Product name: Labetalol (hydrochloride)
Purity: ≥98%
Packaging: 1g
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 20249
Product name: Labetalol (hydrochloride)
Purity: ≥98%
Packaging: 5g
Price: $93
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1335
Product name: Labetalol Hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1g
Price: $97.5
Updated: 2024/03/01

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Labetalol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White or almost white powder.

Originator

Trandate,Allen and Hanburys,UK,1977

Uses

tropane alkaloid, anticholinergic drug

Uses

vasoconstrictor

Definition

ChEBI: Labetalol hydrochloride is a member of salicylamides.

Manufacturing Process

(a) 5-Bromoacetylsalicylamide (2.6 g), N-benzyl-N-(1-methyl-3-phenylpropyl) amine (4.8 g) and methyl ethyl ketone (50 ml) were heated at reflux for 40 minutes. The solvent was removed and the residue was treated with benzene. The secondary amine hydrobromide was filtered off and discarded, and the filtrate was evaporated to dryness. The residue was treated with an excess of ethanolic hydrogen chloride when 5-[N-benzyl-N-(1-methyl-3-phenylpropyl)- glycyl]-salicylamide hydrochloride (1.15 g) crystallized out, MP 139°C to 141°C.
(b) 5-[N-benzyl-N-(1-methyl-3-phenylpropyl)glycyl]-salicylamide hydrochloride (0.75 g), 10% mixture of PdO and PtO on carbon catalyst (0.1 g) and ethanol (20 ml) were shaken at room temperature and pressure with hydrogen until uptake ceased. The catalyst was filtered off and the filtrate evaporated to dryness. The residue was crystallized from ethanol to give 5-[1- hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl]salicylamide hydrochloride as a white solid (0.40 g), MP 188°C.

brand name

Normodyne (Schering); Trandate (Promethus).

Therapeutic Function

Alpha-adrenergic blocker, Beta-adrenergic blocker

Biological Activity

labetalol hcl is a selective antagonist for the α1-adrenergic receptor and a non-selective antagonist for the β-adrenergic receptor. labetalol hcl has been used for the treatment of high blood pressure. labetalol hcl competitively targets the α1-adrenergic receptors expressed in vascular smooth muscle, thus inhibiting adrenergic stimulation on endothelial cells and vasoconstriction in peripheral blood vessels. labetalol hcl also blocks the β-adrenergic receptors in bronchial and vascular smooth muscle to counteract adrenergic stimulation. ultimately, labetalol hcl causes decreases in resting and exercise heart rates, cardiac output, as well as in both systolic and diastolic blood pressure, exherting vasodilation, as well as negative chronotropic and inotropic cardiac effects.1. national center for biotechnology information (2021). pubchem compound summary for cid 3869, labetalol. retrieved august 21, 2021.2. dage rc, hsieh cp. direct vasodilatation by labetalol in anaesthetized dogs. british journal of pharmacology, 1980, 70(2): 287-293.

Labetalol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Labetalol hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Labetalol hydrochloride 32780-64-6
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98.5%-101.0%
Supply Ability: 500kgs
Release date: 2021-08-10

Hebei Mojin Biotechnology Co., Ltd

Product: Labetalol hydrochloride 32780-64-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-07-03

Hebei Guanlang Biotechnology Co., Ltd.

Product: Labetalol hydrochloride 32780-64-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-04-23

32780-64-6, Labetalol hydrochlorideRelated Search:

5-acetyl-2-(phenylmethoxy)benzamide Labetalol IMpurity A Labetalol EP impurity D 5-formyl-2-hydroxybenzamide 5-(N,N-Dibenzylglycyl)salicylamide MDAT Labetalone hydrochloride DILEVALOL HYDROCHLORIDE Labetalol IMpurity B 5-(bromoacetyl)-2-(phenylmethoxy)benzamide (R)-N-benzyl-4-phenylbutan-2-amine Labetalol EP impurity C 5-(2-Bromo-1-hydroxyethyl)-2-hydroxy-benzoic Acid Methyl Ester Labetalol Hydrochloride Impurity 19（(R,S)-Labetalol Hydrochloride） rac 4-(3-Aminobutyl)phenol Salicylamide DILEVALOL SYNEPHRINE

5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)salicylamidehydrochlori

5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-salicylamidhydroch

ah5158a

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5-[1-HYDROXY-2-[(1-METHYL-3-PHENYLPROPYL)-AMINO]ETHYL]SALICYLAMIDE HYDROCHLORIDE

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LABETALOLHYDROCHLORIDE,USP

Labetalol Hydrochloride(USP28/EP5/BP2003)

2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide hydrochloride

Labetalol hydrochloride,2-Hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]benzamide hydrochloride

Labetalol Hydrochloride (200 mg)

AH-5158 hydrochloride

Trandate

2-Hydroxy-5-(1-hydroxy-2-(4-phenylbutan-2-ylaMino)ethyl)benzaMide HCl

2-hydroxy-5-(1-hydroxy-2-((R)-4-phenylbutan-2-ylamino)ethyl)benzamide hydrochloride

BenzaMide,2-hydroxy-5-[1-hydroxy-2-[(1-Methyl-3-phenylpropyl)aMino]ethyl]-, hydrochloride(1:1)

2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-benzamide,hydrochloride (1:1)

Labetalol hydrochlorideLabetalol hydrochloride

2-hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)-benzamidmo

Labeint-A7

labrocol

normadate

normodyne

presdate

pressalolo

sch15719w

2-HYDROXY-5-(1-HYDROXY-2-[(1-METHYL-3-PHENYLPROPYL)AMINO]BENZAMIDE) HYDROCHLORIDE

2-HYDROXY-5-[1-HYDROXY-2-([1-METHYL-3-PHENYLPROPYL]AMINO)-ETHYL]BENZAMIDE HYDROCHLORIDE

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rac-Labetalol Hydrochloride

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32780-64-6

C19H24N2O3HCl

C19H24N2O3ClH

C19H24N2O3HClC19H25ClN2O3

C19H24N2O3HClC19H25ClN2

WYAMINE