Labetalol hydrochloride
- Product Name
- Labetalol hydrochloride
- CAS No.
- 32780-64-6
- Chemical Name
- Labetalol hydrochloride
- Synonyms
- LABETALOL HCL;normodyne;5-[1-HYDROXY-2-[(1-METHYL-3-PHENYLPROPYL)-AMINO]ETHYL]SALICYLAMIDE HYDROCHLORIDE;ipolab;labelol;ah5158a;amipress;Trandate;labrocol;presdate
- CBNumber
- CB8334888
- Molecular Formula
- C19H25ClN2O3
- Formula Weight
- 364.87
- MOL File
- 32780-64-6.mol
Labetalol hydrochloride Property
- Melting point:
- 187-189°
- storage temp.
- 2-8°C
- solubility
- H2O: soluble
- form
- powder
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- L1011
- Product name
- Labetalol hydrochloride
- Purity
- >98% (TLC), powder
- Packaging
- 5g
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 1356654
- Product name
- Labetalol hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 20249
- Product name
- Labetalol (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20249
- Product name
- Labetalol (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $93
- Updated
- 2024/03/01
- Product number
- PHR1335
- Product name
- Labetalol Hydrochloride
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $97.5
- Updated
- 2024/03/01
Labetalol hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White or almost white powder.
Chemical Properties
Labetalol HCl is a white or off-white crystalline powder, soluble in water. Labetalol hydrochloride injection is a clear, colorless to light yellow, aqueous, sterile, isotonic solution for intravenous (IV) injection. It has a pH range of 3.0 to 4.5. Each mL contains 5 mg labetalol hydrochloride USP, 45 mg anhydrous dextrose, 0.10 mg edetate disodium; 0.80 mg of methylparaben and 0.10 mg of propylparaben as preservatives; and citric acid monohydrate and sodium hydroxide, as necessary, to bring the solution into the pH range[1].
Originator
Trandate,Allen and Hanburys,UK,1977
Uses
tropane alkaloid, anticholinergic drug
Uses
vasoconstrictor
Definition
ChEBI: Labetalol hydrochloride is a member of salicylamides.
Indications
Labetalol hydrochloride is indicated for the control of blood pressure in patients with severe hypertension. Labetalol hydrochloride is also used to treat severe or mild pregnancy hypertension (PIH).
Manufacturing Process
(a) 5-Bromoacetylsalicylamide (2.6 g), N-benzyl-N-(1-methyl-3-phenylpropyl)
amine (4.8 g) and methyl ethyl ketone (50 ml) were heated at reflux for 40
minutes. The solvent was removed and the residue was treated with benzene.
The secondary amine hydrobromide was filtered off and discarded, and the
filtrate was evaporated to dryness. The residue was treated with an excess of
ethanolic hydrogen chloride when 5-[N-benzyl-N-(1-methyl-3-phenylpropyl)-
glycyl]-salicylamide hydrochloride (1.15 g) crystallized out, MP 139°C to
141°C.
(b) 5-[N-benzyl-N-(1-methyl-3-phenylpropyl)glycyl]-salicylamide
hydrochloride (0.75 g), 10% mixture of PdO and PtO on carbon catalyst (0.1
g) and ethanol (20 ml) were shaken at room temperature and pressure with
hydrogen until uptake ceased. The catalyst was filtered off and the filtrate
evaporated to dryness. The residue was crystallized from ethanol to give 5-[1-
hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl]salicylamide hydrochloride as
a white solid (0.40 g), MP 188°C.
brand name
Normodyne (Schering); Trandate (Promethus).
Therapeutic Function
Alpha-adrenergic blocker, Beta-adrenergic blocker
Biological Activity
labetalol hcl is a selective antagonist for the α1-adrenergic receptor and a non-selective antagonist for the β-adrenergic receptor. labetalol hcl has been used for the treatment of high blood pressure. labetalol hcl competitively targets the α1-adrenergic receptors expressed in vascular smooth muscle, thus inhibiting adrenergic stimulation on endothelial cells and vasoconstriction in peripheral blood vessels. labetalol hcl also blocks the β-adrenergic receptors in bronchial and vascular smooth muscle to counteract adrenergic stimulation. ultimately, labetalol hcl causes decreases in resting and exercise heart rates, cardiac output, as well as in both systolic and diastolic blood pressure, exherting vasodilation, as well as negative chronotropic and inotropic cardiac effects.1. national center for biotechnology information (2021). pubchem compound summary for cid 3869, labetalol. retrieved august 21, 2021.2. dage rc, hsieh cp. direct vasodilatation by labetalol in anaesthetized dogs. british journal of pharmacology, 1980, 70(2): 287-293.
References
[1] Labetalol Hydrochloride[J]. Definitions, 2020. DOI:10.1002/9780470909799.ch11.
Labetalol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Labetalol hydrochloride manufacturers
- Product
- Labetalol hydrochloride 32780-64-6
- Price
- US $1000.00-800.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-16
- Product
- Labetalol hydrochloride 32780-64-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98.5%-101.0%
- Supply Ability
- 500kgs
- Release date
- 2021-08-10
- Product
- Labetalol HCl 32780-64-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1000
- Release date
- 2024-05-22