M-3M3FBS

Product Name: M-3M3FBS
CAS No.: 200933-14-8
Chemical Name: M-3M3FBS
Synonyms: M-3M3FBS;Phospholipase C Activator,;2,4,6-TRIMETHYL-N-(3-(TRIFLUOROMETHYL)PH;N-(3-TRIFLUOROMETHYLPHENYL)-2,4,6-TRIMETHYLBENZENESULFONAMIDE;2,4,6-TRIMETHYL-N-(M-3-TRIFLUOROMETHYLPHENYL)BENZENESULFONAMIDE;2,4,6-TRIMETHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZENESULFONAMIDE;Benzenesulfonamide, 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]-;Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem;calcium,superoxide,cells,THP-1,phosphate,m 3M3FBS,m-3M3FBS,Apoptosis,Inhibitor,m3M3FBS,Phospholipase,leukemic,U937,inositol,inhibit,neutrophils,m-3M-3FBS
CBNumber: CB8335416
Molecular Formula: C16H16F3NO2S
Formula Weight: 343.36
MOL File: 200933-14-8.mol

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M-3M3FBS Property

Melting point:: 114-114.8 °C(lit.)
Boiling point:: 420.0±55.0 °C(Predicted)
Density: 1.316±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: 92 mg/mL
form: solid
pka: 7.82±0.10(Predicted)
color: white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T5699
Product name: m-3M3FBS
Purity: >97% (HPLC)
Packaging: 10mg
Price: $148
Updated: 2024/03/01

Sigma-Aldrich

Product number: 525185
Product name: Phospholipase C Activator,
Purity: The Phospholipase C Activator,
Packaging: 10mg
Price: $111
Updated: 2024/03/01

Alfa Aesar

Product number: J65999
Product name: 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Packaging: 10mg
Price: $101
Updated: 2021/12/16

Alfa Aesar

Product number: J65999
Product name: 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Packaging: 50mg
Price: $321
Updated: 2021/12/16

Cayman Chemical

Product number: 16867
Product name: m-3M3FBS
Purity: ≥95%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

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M-3M3FBS Chemical Properties,Usage,Production

Description

m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types.1?Inhibits growth of U937 and THP-1 cells.2 m-3M3FBS also affects calcium homeostasis independently of PLC activation.3

Uses

m-3M3FBS is used in biological studies as phospholipase C activator m-3M3FBS effects on Ca2+ homeostasis independently of phospholipase C activation.

Uses

m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis¹. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells².

Definition

ChEBI: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide is a sulfonamide.

Biological Activity

Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca 2+ release and inositol phosphate formation in a variety of cell types.

Biochem/physiol Actions

First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).

storage

Store at RT

References

1) Bae?et al. (2003),?Identification of a compound that directly stimulates phospholipase C activity; Mol. Pharmacol.,?63?1043 2) Lee?et al. (2005),?The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis; Cancer Lett.,?222?227 3) Krjukova?et al. (2004),?Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation; Br. J. Pharmacol.,?143?3

M-3M3FBS Preparation Products And Raw materials

Raw materials

Preparation Products

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M-3M3FBS Suppliers

China 48 Germany 2 Switzerland 1 United Kingdom 3 United States 15 Global 69

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
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Alfa Aesar

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VDM Biochemicals

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BOC Sciences

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Sigma-Aldrich

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Shanghai Lollane Biological Technology Co.,Ltd.

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EMMX Biotechnology LLC

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Shanghai EFE Biological Technology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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200933-14-8, M-3M3FBSRelated Search:

Brilliant Pink FBS FBS, Fetal Bovine Serum,FBS GOLD,FBS SILVER,FBS Benzenesulfonamide, 2,4,6-trimethyl- (9CI) P-TOLUENESULFONANILIDE M-3M3FBS O-3M3FBS CELLECT FBS GOLD GRACE'S INSECT MEDIUM W/O FBS 2-methyl-N-phenylbenzenesulfonamide FBS gamma -Irradiated USA origin FBS USA origin FBS Heat Inactivated CANADIAN origin FBS Heat Inactivated EU approved FBS gamma -Irradiated AUSTRALIAN origin FBS ES cell tested USA origin FBS low IgG EU approved FBS Dialysed AUSTRALIAN origin FBS Dialysed CANADIAN origin

N-(3-TRIFLUOROMETHYLPHENYL)-2,4,6-TRIMETHYLBENZENESULFONAMIDE

2,4,6-TRIMETHYL-N-(3-(TRIFLUOROMETHYL)PH

Phospholipase C Activator,

M-3M3FBS

2,4,6-TRIMETHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZENESULFONAMIDE

2,4,6-TRIMETHYL-N-(M-3-TRIFLUOROMETHYLPHENYL)BENZENESULFONAMIDE

Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem

Benzenesulfonamide, 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]-

calcium,superoxide,cells,THP-1,phosphate,m 3M3FBS,m-3M3FBS,Apoptosis,Inhibitor,m3M3FBS,Phospholipase,leukemic,U937,inositol,inhibit,neutrophils,m-3M-3FBS

200933-14-8

Lipid signaling