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M-3M3FBS

Product Name
M-3M3FBS
CAS No.
200933-14-8
Chemical Name
M-3M3FBS
Synonyms
M-3M3FBS;Phospholipase C Activator,;2,4,6-TRIMETHYL-N-(3-(TRIFLUOROMETHYL)PH;N-(3-TRIFLUOROMETHYLPHENYL)-2,4,6-TRIMETHYLBENZENESULFONAMIDE;2,4,6-TRIMETHYL-N-(M-3-TRIFLUOROMETHYLPHENYL)BENZENESULFONAMIDE;2,4,6-TRIMETHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZENESULFONAMIDE;Benzenesulfonamide, 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]-;Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem;calcium,superoxide,cells,THP-1,phosphate,m 3M3FBS,m-3M3FBS,Apoptosis,Inhibitor,m3M3FBS,Phospholipase,leukemic,U937,inositol,inhibit,neutrophils,m-3M-3FBS
CBNumber
CB8335416
Molecular Formula
C16H16F3NO2S
Formula Weight
343.36
MOL File
200933-14-8.mol
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M-3M3FBS Property

Melting point:
114-114.8 °C(lit.)
Boiling point:
420.0±55.0 °C(Predicted)
Density 
1.316±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: 92 mg/mL
form 
solid
pka
7.82±0.10(Predicted)
color 
white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T5699
Product name
m-3M3FBS
Purity
>97% (HPLC)
Packaging
10mg
Price
$148
Updated
2024/03/01
Sigma-Aldrich
Product number
525185
Product name
Phospholipase C Activator,
Purity
The Phospholipase C Activator,
Packaging
10mg
Price
$111
Updated
2024/03/01
Alfa Aesar
Product number
J65999
Product name
2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Packaging
10mg
Price
$101
Updated
2021/12/16
Alfa Aesar
Product number
J65999
Product name
2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Packaging
50mg
Price
$321
Updated
2021/12/16
Cayman Chemical
Product number
16867
Product name
m-3M3FBS
Purity
≥95%
Packaging
5mg
Price
$49
Updated
2024/03/01
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M-3M3FBS Chemical Properties,Usage,Production

Description

m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types.1?Inhibits growth of U937 and THP-1 cells.2 m-3M3FBS also affects calcium homeostasis independently of PLC activation.3

Uses

m-3M3FBS is used in biological studies as phospholipase C activator m-3M3FBS effects on Ca2+ homeostasis independently of phospholipase C activation.

Uses

m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis1. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells2.

Definition

ChEBI: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide is a sulfonamide.

Biological Activity

Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca 2+ release and inositol phosphate formation in a variety of cell types.

Biochem/physiol Actions

First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).

storage

Store at RT

References

1) Bae?et al. (2003),?Identification of a compound that directly stimulates phospholipase C activity; Mol. Pharmacol.,?63?1043 2) Lee?et al. (2005),?The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis; Cancer Lett.,?222?227 3) Krjukova?et al. (2004),?Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation; Br. J. Pharmacol.,?143?3

M-3M3FBS Preparation Products And Raw materials

Raw materials

Preparation Products

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M-3M3FBS Suppliers

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200933-14-8, M-3M3FBSRelated Search:

Brilliant Pink FBS FBS, Fetal Bovine Serum,FBS GOLD,FBS SILVER,FBS Benzenesulfonamide, 2,4,6-trimethyl- (9CI) P-TOLUENESULFONANILIDE M-3M3FBS O-3M3FBS CELLECT FBS GOLD GRACE'S INSECT MEDIUM W/O FBS 2-methyl-N-phenylbenzenesulfonamide FBS gamma -Irradiated USA origin FBS USA origin FBS Heat Inactivated CANADIAN origin FBS Heat Inactivated EU approved FBS gamma -Irradiated AUSTRALIAN origin FBS ES cell tested USA origin FBS low IgG EU approved FBS Dialysed AUSTRALIAN origin FBS Dialysed CANADIAN origin

  • N-(3-TRIFLUOROMETHYLPHENYL)-2,4,6-TRIMETHYLBENZENESULFONAMIDE
  • 2,4,6-TRIMETHYL-N-(3-(TRIFLUOROMETHYL)PH
  • Phospholipase C Activator,
  • M-3M3FBS
  • 2,4,6-TRIMETHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZENESULFONAMIDE
  • 2,4,6-TRIMETHYL-N-(M-3-TRIFLUOROMETHYLPHENYL)BENZENESULFONAMIDE
  • Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem
  • Benzenesulfonamide, 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]-
  • calcium,superoxide,cells,THP-1,phosphate,m 3M3FBS,m-3M3FBS,Apoptosis,Inhibitor,m3M3FBS,Phospholipase,leukemic,U937,inositol,inhibit,neutrophils,m-3M-3FBS
  • 200933-14-8
  • Lipid signaling