M-3M3FBS
- Product Name
- M-3M3FBS
- CAS No.
- 200933-14-8
- Chemical Name
- M-3M3FBS
- Synonyms
- M-3M3FBS;Phospholipase C Activator,;2,4,6-TRIMETHYL-N-(3-(TRIFLUOROMETHYL)PH;N-(3-TRIFLUOROMETHYLPHENYL)-2,4,6-TRIMETHYLBENZENESULFONAMIDE;2,4,6-TRIMETHYL-N-(M-3-TRIFLUOROMETHYLPHENYL)BENZENESULFONAMIDE;2,4,6-TRIMETHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZENESULFONAMIDE;Benzenesulfonamide, 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]-;Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem;calcium,superoxide,cells,THP-1,phosphate,m 3M3FBS,m-3M3FBS,Apoptosis,Inhibitor,m3M3FBS,Phospholipase,leukemic,U937,inositol,inhibit,neutrophils,m-3M-3FBS
- CBNumber
- CB8335416
- Molecular Formula
- C16H16F3NO2S
- Formula Weight
- 343.36
- MOL File
- 200933-14-8.mol
M-3M3FBS Property
- Melting point:
- 114-114.8 °C(lit.)
- Boiling point:
- 420.0±55.0 °C(Predicted)
- Density
- 1.316±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: 92 mg/mL
- form
- solid
- pka
- 7.82±0.10(Predicted)
- color
- white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T5699
- Product name
- m-3M3FBS
- Purity
- >97% (HPLC)
- Packaging
- 10mg
- Price
- $148
- Updated
- 2024/03/01
- Product number
- 525185
- Product name
- Phospholipase C Activator,
- Purity
- The Phospholipase C Activator,
- Packaging
- 10mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- J65999
- Product name
- 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
- Packaging
- 10mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- J65999
- Product name
- 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
- Packaging
- 50mg
- Price
- $321
- Updated
- 2021/12/16
- Product number
- 16867
- Product name
- m-3M3FBS
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
M-3M3FBS Chemical Properties,Usage,Production
Description
m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types.1?Inhibits growth of U937 and THP-1 cells.2 m-3M3FBS also affects calcium homeostasis independently of PLC activation.3
Uses
m-3M3FBS is used in biological studies as phospholipase C activator m-3M3FBS effects on Ca2+ homeostasis independently of phospholipase C activation.
Uses
m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis1. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells2.
Definition
ChEBI: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide is a sulfonamide.
Biological Activity
Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca 2+ release and inositol phosphate formation in a variety of cell types.
Biochem/physiol Actions
First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).
storage
Store at RT
References
1) Bae?et al. (2003),?Identification of a compound that directly stimulates phospholipase C activity; Mol. Pharmacol.,?63?1043 2) Lee?et al. (2005),?The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis; Cancer Lett.,?222?227 3) Krjukova?et al. (2004),?Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation; Br. J. Pharmacol.,?143?3