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RET Kinase inhibitor 1

Product Name
RET Kinase inhibitor 1
CAS No.
1627856-64-7
Chemical Name
RET Kinase inhibitor 1
Synonyms
CS-2597;GSK3179106;GSK-3179106;RET Kinase inhibitor 1;c-RET inhibitor GS3179106;Benzeneacetamide, 4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-;syndrome,post-inflammatory,visceral,stress-induced,irritable,RET,Inhibitor,bowel,hypersensitivity,orally,GSK 3179106,inhibit,IBS,GSK3179106,GSK-3179106
CBNumber
CB83356171
Molecular Formula
C22H21F4N3O4
Formula Weight
467.41
MOL File
1627856-64-7.mol
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RET Kinase inhibitor 1 Property

Boiling point:
670.1±55.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO:81.0(Max Conc. mg/mL);173.29(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.53(Max Conc. mM)
Ethanol:15.5(Max Conc. mg/mL);33.16(Max Conc. mM)
form 
A crystalline solid
pka
10.30±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24023
Product name
RET Kinase Inhibitor 1
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24023
Product name
RET Kinase Inhibitor 1
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
24023
Product name
RET Kinase Inhibitor 1
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
24023
Product name
RET Kinase Inhibitor 1
Packaging
25mg
Price
$533
Updated
2024/03/01
ChemScene
Product number
CS-7799
Product name
GSK3179106
Purity
99.40%
Packaging
50mg
Price
$800
Updated
2021/12/16
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RET Kinase inhibitor 1 Chemical Properties,Usage,Production

Description

GSK3179106 is an inhibitor of rearranged during transfection (RET) kinase (IC50 = 0.4 nM). It is selective for RET kinase over VEGF receptor 2 (VEGFR2/KDR; IC50 = 109 nM). GSK3179106 reduces the number of abdominal contractions induced by colorectal distension in acetic acid-sensitized rats when administered at a dose of 10 mg/kg twice per day.

RET Kinase inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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RET Kinase inhibitor 1 Suppliers

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1627856-64-7, RET Kinase inhibitor 1Related Search:

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide GSK484 GSK583 GSK369796 GSK461364 GSK547 GSK-467 GSK481 GSK-3326595 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide

  • CS-2597
  • c-RET inhibitor GS3179106
  • RET Kinase inhibitor 1
  • GSK3179106
  • GSK-3179106
  • Benzeneacetamide, 4-(4-ethoxy-1,6-dihydro-6-oxo-3-pyridinyl)-2-fluoro-N-[5-(2,2,2-trifluoro-1,1-dimethylethyl)-3-isoxazolyl]-
  • syndrome,post-inflammatory,visceral,stress-induced,irritable,RET,Inhibitor,bowel,hypersensitivity,orally,GSK 3179106,inhibit,IBS,GSK3179106,GSK-3179106
  • 1627856-64-7
  • C22H21F4N3O4