ChemicalBook > CAS DataBase List > AX-024 hydrochloride

AX-024 hydrochloride

Product Name
AX-024 hydrochloride
CAS No.
1704801-24-0
Chemical Name
AX-024 hydrochloride
Synonyms
AX-024;AX-024;AX024;AX 024;AX-024 hydrochloride;1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride;AX 024,Interleukin Related,Inhibitor,inhibit,Tumor Necrosis Factor Receptor,AX024 hydrochloride,TNFR,Interferon-α/β receptor,AX024,AX-024,IFNAR,TNF Receptor,AX 024 hydrochloride,Interferon-alpha/beta receptor
CBNumber
CB83364105
Molecular Formula
C21H23ClFNO2
Formula Weight
375.87
MOL File
1704801-24-0.mol
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AX-024 hydrochloride Property

storage temp. 
-20°
solubility 
Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (10 mg/ml with warming).
form 
solid
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27333
Product name
AX-024 (hydrochloride)
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
27333
Product name
AX-024 (hydrochloride)
Packaging
25mg
Price
$680
Updated
2024/03/01
Cayman Chemical
Product number
27333
Product name
AX-024 (hydrochloride)
Packaging
5mg
Price
$167
Updated
2024/03/01
Cayman Chemical
Product number
27333
Product name
AX-024 (hydrochloride)
Packaging
10mg
Price
$312
Updated
2024/03/01
ChemScene
Product number
CS-8002
Product name
AX-024hydrochloride
Packaging
10mg
Price
$300
Updated
2021/12/16
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AX-024 hydrochloride Chemical Properties,Usage,Production

Description

AX-024 is an inhibitor of the CD3ε-Nck interaction. It binds to the SH3.1 N-terminal domain of Nck1, preventing its binding to the proline-rich sequence of the CD3ε subunit of T cells. AX-024 inhibits T cell receptor-triggered T cell activation (IC50 = 1 nM for human T cells) and selectively decreases proliferation of T cells over B cells. It prevents CD4+ T cell and macrophage infiltration to the cerebellum and spinal cord and improves neurological impairments in a MOG35-55 mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at a dose of 10 mg/kg per day for ten days starting on the day of immunization. AX-024 (50 mg/kg) prevents the infiltration of eosinophils, macrophages, and neutrophils into the airway, as well as prevents an increase in IL-4 levels in bronchoalveolar lavage fluid (BALF), in an ovalbumin-sensitized mouse model of allergic airway disease. It does not prevent the memory T cell response to an immunodominant B8R poxvirus antigen peptide or to infection by ectromelia virus (mousepox).

Uses

AX-024 is a T cell receptor inhibitor for the treatment of autoimmune diseases.

References

1) Borroto et al. (2016), First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases; Sci. Transl. Med., 8 370ra184

AX-024 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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AX-024 hydrochloride Suppliers

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1704801-24-0, AX-024 hydrochlorideRelated Search:

Phytosphingosine SR 1001 BESTATIN HYDROCHLORIDE Zileuton inhibition of the Dvl and Axin complex

  • AX-024;AX024;AX 024
  • AX-024 hydrochloride
  • AX-024
  • 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride
  • AX 024,Interleukin Related,Inhibitor,inhibit,Tumor Necrosis Factor Receptor,AX024 hydrochloride,TNFR,Interferon-α/β receptor,AX024,AX-024,IFNAR,TNF Receptor,AX 024 hydrochloride,Interferon-alpha/beta receptor
  • 1704801-24-0