TETRAGASTRIN
- Product Name
- TETRAGASTRIN
- CAS No.
- 1947-37-1
- Chemical Name
- TETRAGASTRIN
- Synonyms
- TETRAGASTRIN;CCK-4 Acetate;Trp-Met-Asp-Phe amide;Cholecystokinin(36-39);Tetragastrin hydrochloride;CCK-4, CCKB receptor agonist;H-Trp-Met-Asp-Phe-NH2 acetate;Cholecystokinin, CCK Tetrapeptide;4-7-Cholecystokinin-7 (swine) (9CI);CCK-4 Acetate, Gastrin Tetrapeptide
- CBNumber
- CB8341406
- Molecular Formula
- C29H36N6O6S
- Formula Weight
- 596.7
- MOL File
- 1947-37-1.mol
TETRAGASTRIN Property
- Melting point:
- 185-195 °C
- Boiling point:
- 1070.0±65.0 °C(Predicted)
- Density
- 1.348±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 20mg/mL, clear, colorless to yellow
- form
- Solid
- pka
- 4.19±0.10(Predicted)
- color
- White to off-white
Safety
- WGK Germany
- 3
- Toxicity
- dog,LD,intravenous,> 100mg/kg (100mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: EXCITEMENT,Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 121, 1969.
N-Bromosuccinimide Price
- Product number
- T6515
- Product name
- Cholecystokinin Fragment 30-33 Amide
- Purity
- ≥95% (HPLC)
- Packaging
- 100mg
- Price
- $284
- Updated
- 2024/03/01
- Product number
- PEP0011758
- Product name
- TETRAGASTRIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.32
- Updated
- 2021/12/16
TETRAGASTRIN Chemical Properties,Usage,Production
Uses
Cholecystokinin Fragment 30-33 Amide can be used for inactivating the CCK8 antiserum. The product can also be used as an antigen utilized in absorption control for testing the specificity of antisera.
Definition
ChEBI: Tetragastrin is a tetrapeptide composed of L-tryptophan, L-methione, L-aspartic acid and L-phenylalaninamide residues joined in sequence. It has a role as an anxiogenic and a human metabolite. It is a tetrapeptide and a peptidyl amide.
Hazard
Moderately toxic by ingestion
Biochem/physiol Actions
Cholecystokinin Fragment 30-33 Amide also referred to as CCK-4 or Trp-Met-Asp-Phe amide is a peptide fragment derived from peptide hormone cholecystokinin. CCK-4 is a panicogenic agent that induces panic attacks in humans. This property of the compound can be used in scientific research for testing the new anxiolytic drugs.
in vivo
In inbred Wistar rats treated with N-methyl-N'-nitro-N-nitrosoguanidine, Tetragastrin (s.c.; 1 mg/kg; every other day) treatment significantly reduces the incidence and the number of adenocarcinomas, and has a significantly lower labelling index of the antral mucosa[1].
Tetragastrin has potential for enhancing gastric mucosal protection associated with mucus secretion and/or mucus synthesis on the surface mucosa of rat gastric mucosa. A significant increase in the mucin content was noted in the mucus gel and surface mucosal layer. An increase in mucin in the mucus gel and surface mucosa would thus appear due to the administration of Tetragastrin[3].
| Animal Model: | Seven-week-old male Wistar rats, each weighing approximately 160 g[3] |
| Dosage: | 12, 120, or 400 μg/kg |
| Administration: | Administered subcutaneously (s.c.); followed by 50% ethanol-induced gastric injury |
| Result: | Caused a significant increase in mucin content in the corpus mucosa and prevented 50% ethanol-induced gastric mucosal damage in a dose-dependent manner. |
TETRAGASTRIN Preparation Products And Raw materials
Raw materials
Preparation Products
TETRAGASTRIN Suppliers
- Tel
- --
- Fax
- --
- info@glenthamls.com
- Country
- United Kingdom
- ProdList
- 1429
- Advantage
- 0