Norepinephrine

ChemicalBook > CAS DataBase List > Norepinephrine

Product Name: Norepinephrine
CAS No.: 51-41-2
Chemical Name: Norepinephrine
Synonyms: NORADRENALINE;L-NORADRENALINE;NORADRENALIN;levophed;adrenor;aktamin;norartrinal;levoarterenol;(?)-Norepinephrine;arterenolfreebase(noradrenaline)
CBNumber: CB8346810
Molecular Formula: C8H11NO3
Formula Weight: 169.18
MOL File: 51-41-2.mol

Less

Norepinephrine Property

Melting point:: 220-230°C
alpha: D25 -37.3° (c = 5 in water with 1 equiv HCl)
Boiling point:: 298.46°C (rough estimate)
Density: 1.2435 (rough estimate)
refractive index: 1.5100 (estimate)
storage temp.: 2-8°C
solubility: Aqueous Acid (Slightly), DMSO (Slightly)
pka: 8.64(at 25℃)
form: crystalline
color: off-white to tan
Water Solubility: Soluble in alkali and dilute hydrochloric acid. Slightly soluble in water, ethanol and diethyl ether.
Sensitive: Air & Light Sensitive
Merck: 14,6695
BRN: 4231961
Stability:: Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20℃.
CAS DataBase Reference: 51-41-2(CAS DataBase Reference)
EPA Substance Registry System: Norepinephrine (51-41-2)

Less

Safety

Hazard Codes: T+,C,F
Risk Statements: 26/27/28-34-11-28
Safety Statements: 28-36/37-45-36/37/39-26-16-20
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: DN5950000
F: 8-10-23
HazardClass: 6.1
PackingGroup: II
HS Code: 29225090
Hazardous Substances Data: 51-41-2(Hazardous Substances Data)
Toxicity: dni-hmn:oth 5800 nmol/L CNREA8 40,1414,80

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A7257
Product name: (?)-Norepinephrine
Purity: ≥98%, crystalline
Packaging: 1g
Price: $417
Updated: 2024/03/01

Sigma-Aldrich

Product number: A7257
Product name: (?)-Norepinephrine
Purity: ≥98%, crystalline
Packaging: 5g
Price: $1500
Updated: 2024/03/01

Alfa Aesar

Product number: L08087
Product name: L-Noradrenaline, 98%
Packaging: 1g
Price: $359
Updated: 2024/03/01

Sigma-Aldrich

Product number: A7257
Product name: (?)-Norepinephrine
Purity: ≥98%, crystalline
Packaging: 500mg
Price: $228
Updated: 2024/03/01

TRC

Product number: N661038
Product name: L-Noradrenaline
Packaging: 1g
Price: $265
Updated: 2021/12/16

Less

Norepinephrine Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

Vascular active drug resistance to shock

Uses

An adrenergic neurotransmitter.

Uses

Norepinephrine is used for increasing cardiac constriction and for the necessary elevation of blood pressure after sharp decline, which can result from surgical intervention or trauma.

Definition

ChEBI: The R-enantiomer of noradrenaline.

brand name

Levophed (Hospira);Noradrec;Xylotox.

World Health Organization (WHO)

Vasoconstrictor agents have been in use for many years to prolong duration of action of local anaesthetics, particularly in dentistry. Combination products containing epinephrine or levarterenol in concentrations of 1:80,000 or less remain widely available. See also WHO comment for epinephrine.

Biological Functions

Most central noradrenergic neurons are located in the nucleus locus ceruleus of the pons and in neurons of the reticular formation. Fibers from these nuclei innervate a large number of cortical, subcortical, and spinomedullary fields. Many functions have been ascribed to the central noradrenergic neurons, including a role in affective disorders (see Chapter 33), in learning and memory, and in sleep–wake cycle regulation.The mammalian CNS contains both α- and β-adrenoceptors.

General Description

Norepinephrine (NE, Levophed) differs from DA onlyby addition of a 1-OH substituent (β-OH-DA) and from Eonly by lacking the N-methyl group. Like DA, it is polar andrapidly metabolized by both COMT and MAO, resulting inpoor oral bioavailability and short DOA (1 or 2 minutes evenwhen given intravenously). It is a stimulant of α1-, α2-, andβ1-adrenoceptors (notice that lacking the N-methyl group resultsin lacking β2- and β3-activity). It is used to counteractvarious hypotensive crises, because its α-activity raisesblood pressure and as an adjunct treatment in cardiac arrestbecause its β-activity stimulates the heart. It has limitedclinical application caused by the nonselective nature of itsactivities.

Hazard

May cause local tissue necrosis, headache, bradycardia, hypertension; poison; teratogen; mutagen.

Biochem/physiol Actions

Adrenergic neurotransmitter

Pharmacology

Norepinephrine is the primary neurotransmitter produced and released by adrenergic neurons, and in literature it is also described as and called () noradrenaline or levarterenol. This vasopressor catecholamine reduces both the resistance and capacity of blood vessels by stimulating α-adrenoreceptors and having a direct cardiostimulatory effect, which is accomplished by activation of β1-adrenoreceptors. Norepinephrine exhibits significantly less activity than epinephrine as a drug for widening blood vessels through the activation of β2-adrenoreceptors. Elevation of both stylistic and diastolic blood pressure is a typical reaction to intravenous introduction of norepinephrine.

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. A sympathomimetic vasopressor. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

Norepinephrine, L-1-(3,4-dihydroxyphenyl)-2-aminoethanol (11.1.4), is synthesized by two methods starting from 3,4-dihydroxybenzaldehyde. According to the first method, the indicated aldehyde is transformed into the cyanohydrin (11.1.3) by reaction with hydrogen cyanide, which is then reduced into norepinephrine (11.1.5).

The second method consists of the condensation of diacetate of the same aldehyde with nitromethane, which forms (3,4-diacetoxyphenyl)-2-nitroethanol (11.1.5). Then the nitro group is reduced and the product (11.1.6) is hydrolyzed into the desired norepinephrine (11.1.4) [4,9,13,14].

Purification Methods

Recrystallise adrenor from EtOH and store it in the dark under N2. [pKa, Lewis Brit J Pharmacol Chemother 9 488 1954, UV: Bergstr.m et al. Acta Physiol Scand 20 101 1950, Fluorescence: Bowman et al. Science NY 122 32 1955, Tullar J Am Chem Soc 70 2067 1948.] The L-tartrate salt monohydrate has m 102-104.5o, [] D -11o (c 1.6, H2O), after recrystallisation from H2O or EtOH. [Beilstein 13 III 2382.]

Norepinephrine Preparation Products And Raw materials

Raw materials

D(+)-Glucose Starch

Preparation Products

Abamectin

Less

Norepinephrine Suppliers

China 212 Czech 1 Czech Republic 1 Europe 2 Germany 4 India 18 Japan 1 Switzerland 3 United Kingdom 10 United States 38 Global 290

Xinxiang City Oran Biotechnology Co. Ltd.

Tel: 0373-6766851 18568539857
Fax: 0373-6766851
Email: alchemic516@163.com
Country: China
ProdList: 66
Advantage: 58

Hu' nan Yunbang Pharmaceutical Co., Ltd.

Tel: 0731-85561020 15386497078
Email: yunbang@yunbangapi.com
Country: China
ProdList: 4200
Advantage: 58

Hubei Xingcheng Biotechnology Co., Ltd

Tel: 19171210221
Fax: QQ:3505191060
Email: 3371991952@qq.com
Country: China
ProdList: 962
Advantage: 58

Wuhan Chujiang Haoyu Chemical Technology Development Co., Ltd.

Tel: 18171284407
Email: 1850853183@qq.com
Country: China
ProdList: 306
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9551
Advantage: 66

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2893
Advantage: 58

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4941
Advantage: 60

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 4978
Advantage: 50

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22519
Advantage: 55

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: SALES@UHNSHANGHAI.COM
Country: China
ProdList: 977
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3750
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8073
Advantage: 58

Wuhan DKY Technology Co.,Ltd.

Tel: 27-81302488 18007166089
Fax: 027-81302088
Email: info@dkybpc.com
Country: China
ProdList: 2024
Advantage: 58

Shanghai DiBai Chemicals Co., Ltd.

Tel: 021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3993
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17982
Advantage: 56

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 17501653713 17501653715
Email: xingui2022@126.com
Country: China
ProdList: 9988
Advantage: 58

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9911
Advantage: 50

Hangzhou J&H Chemical Co., Ltd.

Tel: +86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 10015
Advantage: 53

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4992
Advantage: 55

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9503
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Watson Biotechnology Co.,Ltd

Tel: 027-027-59207879 18140587686
Fax: QQ：1972026995
Email: kf@3600chem.com
Country: China
ProdList: 4699
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 7059
Advantage: 55

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-50266790 Q3382968513
Fax: QQ3382968513
Email: Hailey@shsendpharm.com
Country: China
ProdList: 3170
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9638
Advantage: 58

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10457
Advantage: 58

Artis Biotech Co. Ltd.

Tel: 19138486554 18582380095
Fax: 0575-89298961
Email: sales@artisbio.com
Country: China
ProdList: 3066
Advantage: 58

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9947
Advantage: 58

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9604
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20810
Advantage: 60

Raw material medicin reagent co.,Ltd

Tel: 025-57798860
Email: sales@njromanme.com
Country: China
ProdList: 4534
Advantage: 58

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2981
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
Advantage: 68

Shenzhen Simeiquan Biotechnology Co. Ltd

Tel: 18126413629 0755-23311925 2355327053
Fax: 0755-23311925
Email: abel@ycgmp.com
Country: China
ProdList: 5115
Advantage: 58

Hubei widely chemical technology Co., Ltd.

Tel: 027-83991130 18627774460
Fax: 027-83991130
Email: 1718093273@QQ.COM
Country: China
ProdList: 1892
Advantage: 58

NanJing FineTech Chemical Co., Ltd

Tel: 17714198479 17714198479
Email: sales@fine-chemtech.com
Country: China
ProdList: 170
Advantage: 58

Shijiazhuang yaoBo Pharmaceutical Co., Ltd.

Tel: 15633056635
Email: 2880679888@qq.com
Country: China
ProdList: 2684
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13374
Advantage: 58

Less

View Lastest Price from Norepinephrine manufacturers

Sinoway Industrial co., ltd.

Product: Norepinephrine 51-41-2
Price: US $125.00-45.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-12-08

Shanghai Affida new material science and technology center

Product: Norepinephrine 51-41-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 50000KG/month
Release date: 2024-03-19

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Norepinephrine 51-41-2
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-09-26

51-41-2, NorepinephrineRelated Search:

2-(METHYLSULFONYL)ETHANOL Hydroquinone 1-Hydroxyethylidene-1,1-diphosphonic acid 3-Diethylaminophenol Tris(hydroxymethyl)aminomethane Catechol Resorcinol tert-Butylhydroquinone 3-Aminophenol ALTRENOGEST 6-Aminocaproic acid 4-tert-Butylcatechol Glycine NOREPINEPHRINE BITARTRATE,L-NOREPINEPHRINE BITARTRATE,L-(-)-NOREPINEPHRINE-(+)-BITARTRATE,NORADRENALINE,L-NORADRENALINE BITARTRATE,noradrenaline,tartrate(1:1 Isoproterenol 4,6,7-Isoquinolinetriol, 1,2,3,4-tetrahydro- Norepinephrine Impurity 23 Norepinephrine Impurity 2 Noradrenalin Noradrenaline

(-)-alpha-(aminomethyl)protocatechuylalcohol

(-)-noradrec

4-(2-amino-1-hydroxyethyl)-2-benzenedio(r)-

adrenor

Adrenaline Impurity 2（Adrenaline EP Impurity B）

aktamin

arterenolfreebase(noradrenaline)

d-(-)-noradrenaline

l-1-(3,4-dihydroxyphenyl)-2-aminoethanol

l-2-amino-1-(3,4-dihydroxyphenyl)ethanol

l-3,4-dihydroxyphenylethanolamine

l-alpha-(aminomethyl)-3,4-dihydroxybenzylalcohol

levoarterenol

levonoradrenaline

levonorepinephrine

levophed

noradrenalina

noradrenline

norartrinal

norepirenamine

sympathine

L-NOREPINEPHRINE

L-NORADRENALINE

LEVARTERENOL

L-ARTERENOL

(-)-ARTERENOL

ARTERENOL (-)-

(R)-4-(2-AMINO-1-HYDROXYETHYL)-1,2-BENZENEDIOL

NORADRENALIN

(-)-NORADRENALINE

NORADRENALINE

(-)-NOREPINEPHRINE

NOREPINEPHRINE

l-arternol

4-(2-amino-1-hydroxy-ethyl)benzene-1,2-diol

(-)-a-(Aminomethyl)protocatechuyl alcohol

(R)-(-)-Norepinephrine

(R)-Norepinephrine

1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-

1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]- (9CI)

l-a-(Aminomethyl)-3,4-dihydroxybenzyl alcohol

Nor-Epirenan

L-Arternol=L-Norepinephrine

(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, L-Arterenol, L-Noradrenaline, Levarterenol

4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol

Epinephrine Impurity B

Noradrenaline(Norepinephrine,NA,NE)

()-Norepinephrine,(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, L-Arterenol, L-Noradrenaline, Levarterenol

Noradrenaline API

Norepinephrine Hydrochloride (Solution)

Norepinephrine HCl (solution)

-NoradrenaL

Norepinephrine USP/EP/BP

Norepinephrine (Noradrenaline)

Norepinephrine USP

(?)-Norepinephrine

SSXS-2

(R)-Norepinephrine,L-Norepinephrine