ChemicalBook > CAS DataBase List > 4-Amino-3-chlorobenzoic acid

4-Amino-3-chlorobenzoic acid

Product Name
4-Amino-3-chlorobenzoic acid
CAS No.
2486-71-7
Chemical Name
4-Amino-3-chlorobenzoic acid
Synonyms
BUTTPARK 29\06-53;4-Amino-3-chlorobe;RARECHEM AL BO 0579;Curcumin Impurity 6;4-Amino-3-chlorobenz;3-chloro-4-aminobenzoate;4-Carboxy-2-chloroaniline;4-AMINO-3-CHLORBENZOIC ACID;4-Amino-3-chlorobenzioc acid;3-CHLORO-4-AMINOBENZOIC ACID
CBNumber
CB8352668
Molecular Formula
C7H6ClNO2
Formula Weight
171.58
MOL File
2486-71-7.mol
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4-Amino-3-chlorobenzoic acid Property

Melting point:
228 °C
Boiling point:
341.2±27.0 °C(Predicted)
Density 
1.476±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
4.49±0.10(Predicted)
color 
White to Orange to Green
CAS DataBase Reference
2486-71-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
691445
Product name
4-Amino-3-chlorobenzoic acid
Purity
97%
Packaging
1g
Price
$33.8
Updated
2023/06/20
Sigma-Aldrich
Product number
691445
Product name
4-Amino-3-chlorobenzoic acid
Purity
97%
Packaging
5g
Price
$82
Updated
2023/06/20
TCI Chemical
Product number
A1971
Product name
4-Amino-3-chlorobenzoic Acid
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$95
Updated
2025/07/31
TRC
Product number
A602845
Product name
4-Amino-3-chlorobenzoic Acid
Packaging
25g
Price
$170
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK428581
Product name
4-Amino-3-chlorobenzoic Acid
Purity
97%
Packaging
1g
Price
$24
Updated
2021/12/16
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4-Amino-3-chlorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

4-?Amino-?3-?chlorobenzoic Acid is a reagent used in the synthesis of orally bioavailable 1H-Pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase MPS1which is overexpressed in cancer cell lines.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

84228-44-4

2486-71-7

General procedure for the synthesis of 3-chloro-4-aminobenzoic acid from methyl 4-amino-3-chlorobenzoate: 1. Saponification reaction: 4-amino-3-chlorobenzoic acid methyl ester (21.6 mmol) was dissolved in ethanol (25 mL) and 1M NaOH aqueous solution (25 mL), and heated to reflux for 2 hours. 2. Post-treatment: after completion of the reaction, the organic solvent was removed by evaporation and the pH of the reaction solution was adjusted to 4 with acid. 3. Isolation and purification: The precipitate was collected by filtration, washed with water and subsequently dried under vacuum to obtain the target product 3-chloro-4-aminobenzoic acid. Yield: 92%. 1H NMR (D6-DMSO) δ: 6.15 (s, 2H), 6.79 (d, 1H), 7.59 (dd, 1H), 7.71 (d, 1H), 12.37 (br s, 1H).

References

[1] Patent: WO2005/39572, 2005, A1. Location in patent: Page/Page column 25
[2] Patent: WO2006/114093, 2006, A1. Location in patent: Page/Page column 37

4-Amino-3-chlorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-3-chlorobenzoic acid Suppliers

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View Lastest Price from 4-Amino-3-chlorobenzoic acid manufacturers

Career Henan Chemical Co
Product
4-Amino-3-chlorobenzoic acid 2486-71-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-01-02

2486-71-7, 4-Amino-3-chlorobenzoic acidRelated Search:

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  • RARECHEM AL BO 0579
  • BUTTPARK 29\06-53
  • 4-Amino-3-chlorobenzoic acid 97%
  • 4-Carboxy-2-chloroaniline
  • 4-AMino-3-chlorobenzoic Acid, 97+%
  • 3-chloro-4-aminobenzoate
  • 4-AMNIO-3-CHLOROBENZIOC ACID
  • 4-AMINO-3-CHLOROBENZOIC ACID
  • 4-AMINO-3-CHLORBENZOIC ACID
  • 3-CHLORO-4-AMINOBENZOIC ACID
  • 4-Amino-3-chlorobenzioc acid
  • 4-Amino-3-chlorobenz
  • 4-Amino-3-chlorobe
  • 4-Amino-3-chlorobenzoic acid >99%
  • 4-Amino-3-chlorobenzoic Acid &gt
  • Benzoic acid, 4-amino-3-chloro-
  • 4-Amino-3-chlorobenzoic acid USP/EP/BP
  • 2486-71-7 98%MIN 4-Amino-3-chlorobenzoic acid factory
  • Curcumin Impurity 6
  • 2486-71-7
  • C7H6CINO2
  • API Intermediate
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • pharmacetical
  • Phenylacetic acid
  • Miscellaneous
  • Benzenes
  • Aromatic Amino AcidsCarbonyl Compounds
  • C7
  • Carboxylic Acids
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives