ChemicalBook > CAS DataBase List > D-Serine methyl ester hydrochloride

D-Serine methyl ester hydrochloride

Product Name
D-Serine methyl ester hydrochloride
CAS No.
5874-57-7
Chemical Name
D-Serine methyl ester hydrochloride
Synonyms
METHYL D-SERINATE HYDROCHLORIDE;D-Serine Methyl Ester HCl;(R)-Methyl 2-Amino-3-hydroxypropanoate Hydrochloride;D-Ser-OMe.HCl;H-D-SER-OME HCL;H-D-Ser-OMe.HCI;D-SERINE-OME HCL;D-Serine methyl este;Cycloserine Impurity 12;Cycloserine Impurity 2 HCl
CBNumber
CB8354930
Molecular Formula
C4H10ClNO3
Formula Weight
155.58
MOL File
5874-57-7.mol
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D-Serine methyl ester hydrochloride Property

Melting point:
163-166 °C(lit.)
alpha 
-4 º (c=4 in ethanol)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in ethanol and methanol.
form 
Liquid
color 
Clear colorless to yellow
optical activity
[α]20/D 4°, c = 4 in ethanol
InChI
InChI=1/C4H9NO3.ClH/c1-8-4(7)3(5)2-6;/h3,6H,2,5H2,1H3;1H/t3-;/s3
InChIKey
NDBQJIBNNUJNHA-AENDTGMFSA-N
SMILES
[C@@H](N)(CO)C(=O)OC.Cl |&1:0,r|
CAS DataBase Reference
5874-57-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
HS Code 
29225000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
445797
Product name
D-Serine methyl ester hydrochloride
Purity
98%
Packaging
5g
Price
$26.85
Updated
2025/07/31
Sigma-Aldrich
Product number
445797
Product name
D-Serine methyl ester hydrochloride
Purity
98%
Packaging
25g
Price
$50.4
Updated
2025/07/31
TCI Chemical
Product number
S0553
Product name
H-D-Ser-OMe·HCl
Packaging
25G
Price
$72
Updated
2025/07/31
TCI Chemical
Product number
S0553
Product name
H-D-Ser-OMe·HCl
Packaging
100G
Price
$178
Updated
2025/07/31
Usbiological
Product number
237245
Product name
D-Serine methyl ester hydrochloride 98+%
Packaging
1g
Price
$163
Updated
2021/12/16
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D-Serine methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

D-Serine Methyl Ester Hydrochloride (cas# 5874-57-7) is a compound useful in organic synthesis.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

312-84-5

5874-57-7

General procedure for the synthesis of D-serine methyl ester hydrochloride from methanol and D-serine: 4.2.1.1 Synthesis of methyl (R)-2-isopropyl-4,5-dihydrooxazole-4-carboxylate First, sulfoxide chloride (SOCl?, 7.60 mL, 104.2 mmol) was slowly added dropwise to a methanolic solution of D-serine (10.0 g, 95.1 mmol) and the reaction mixture was stirred for 24 h at room temperature. After completion of the reaction, the solvent was removed by rotary evaporator to give a white solid. The solid was washed with hexane (3 x 25 mL) to give D-serine methyl ester hydrochloride (14.4 g, 97% yield) as a colorless solid. The product was characterized by 1H NMR (300 MHz, D?O) with the following chemical shifts: δ 4.32-4.28 (1H, m, CH), 4.12 (1H, dd, J = 4.2, 12.5 Hz, CHaHbOH), 4.02 (1H, dd, J = 3.4, 12.5 Hz, CHaHbOH), 3.88 (3H, s, CH?) .

References

[1] Journal of Organic Chemistry, 1997, vol. 62, # 2, p. 372 - 376
[2] Heterocyclic Communications, 2005, vol. 11, # 3-4, p. 343 - 346
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 15, p. 5716 - 5726
[4] Chemical Communications, 2016, vol. 52, # 55, p. 8612 - 8614
[5] Journal of Organic Chemistry, 2003, vol. 68, # 26, p. 10162 - 10165

D-Serine methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from D-Serine methyl ester hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
D-Serine methyl ester hydrochloride 5874-57-7
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2021-10-08
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
D-Ser-OMe·HCl 5874-57-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-04-08
Henan Fengda Chemical Co., Ltd
Product
D-Serine methyl ester hydrochloride 5874-57-7
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-22

5874-57-7, D-Serine methyl ester hydrochlorideRelated Search:

Methyl acrylate Methyl-DL-serine hydrochloride DL-Serine Methylparaben Pyridine hydrochloride D-Cycloserine Bensulfuron methyl L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE L-Homoserine D-Serine Methoxyammonium chloride Kresoxim-methyl Topotecan hydrochloride D-Serine,1,1-dimethylethylester,hydrochloride Thiophanate-methyl Methyl H-D-SER-OBZL HCL H-D-SER-OET HCL

  • D-Serine methyleester hydrochloride
  • H-D-SER-OME HCL
  • D-SERINE METHYL ESTER HYDROCHLORIDE
  • D-SERINE METHYL ESTER HYDROCHLORIDE SALT
  • D-SERINE-OME HCL
  • H-D-Ser-OMe.HCI
  • D-Ser-OMe.HCl
  • METHYL D-SERINATE HYDROCHLORIDE
  • D-Serine Methyl Ester HCl
  • 2-Amino-3-hydroxy-propionic Acid Methyl Ester Hydrochlorid
  • (R)-2-Amino-3-hydroxypropionic Acid Methyl Ester Hydrochloride
  • (R)-Methyl 2-Amino-3-hydroxypropanoate Hydrochloride
  • D-Serine methyl este
  • D-Serine Methyl ester hydrochloride (InterMediate)
  • D-Serine methyl ester hydrochloride,98%
  • D-Serine Methyl ester hydrochloride, 95+%
  • Cycloserine Impurity 2 (D-Serine methyl ester hydrochloride)
  • D-Serine methyl ester hydrochloride 98%
  • D-Serine methyl ester hydrochloride≥ 98% (HPLC)
  • D-β-Hydroxyalanine methyl ester hydrochloride
  • Methyl D-Serine Ester Hydrochloride,99%e.e.
  • Methyl D-Serine Ester Hydrochloride
  • Cycloserine Impurity 2 (D-Serine methyl ester hydochloride)
  • methyl (2R)-2-amino-3-hydroxypropanoate
  • Cycloserine Impurity 12
  • D-Serine, methyl ester, hydrochloride (1:1)
  • Cycloserine Impurity 2 HCl (D-Serine Methyl Ester HCl)
  • Cycloserine Impurity 2 HCl
  • <sc>D</sc>-Serine methyl ester hydrochloride
  • Methyl (R)-2-amino-3-hydroxypropanoate,hydrochloride(1:1)
  • 5874-57-7
  • C4H10NO3Cl
  • C4H9O3NHCl
  • Serine
  • Peptide Synthesis
  • Specialty Synthesis
  • Amino Acid Derivatives
  • Aliphatics
  • Amino Acids & Derivatives
  • Amino Acid Derivatives
  • Peptide Synthesis
  • Serine
  • Amino Acids and Derivatives
  • Amino Acids
  • All Aliphatics
  • Amino hydrochloride
  • Amino ACIDS SERIES