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CHROMOMYCIN A3

Product Name
CHROMOMYCIN A3
CAS No.
7059-24-7
Chemical Name
CHROMOMYCIN A3
Synonyms
TOYOMYCIN;nsc-58514;Chromomycin;aburamycinb;Olivomycin D;CHROMOMYCIN A3;Chromoycin A3;antibioticb599;ABURAMYCIN BETA;nosyl)-7-methyl-
CBNumber
CB8356277
Molecular Formula
C57H82O26
Formula Weight
1183.25
MOL File
7059-24-7.mol
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CHROMOMYCIN A3 Property

Melting point:
185℃
alpha 
D23 -57° (ethanol)
Boiling point:
780.13°C (rough estimate)
Density 
1.1451 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml).
form 
Yellow solid
pka
4.54±0.60(Predicted)
Merck 
13,2258
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Safety

Hazard Codes 
T+,T
Risk Statements 
61-28
Safety Statements 
53-28-36/37/39-45
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
GB7875000
3-8-10
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29419090
Toxicity
Excitation max: ~445 nm. Emission max: ~575 nm. Sol in ethanol, ethyl acetate, DMSO, methanol. LD50 in mice (mg/kg): 1.85 i.v. (Slavik, Carter).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C2659
Product name
Chromomycin A3 from Streptomyces griseus
Purity
≥95% (HPLC)
Packaging
5mg
Price
$249
Updated
2021/12/16
Sigma-Aldrich
Product number
C2659
Product name
Chromomycin A3 from Streptomyces griseus
Purity
≥95% (HPLC)
Packaging
10mg
Price
$416
Updated
2021/12/16
Sigma-Aldrich
Product number
230752
Product name
Chromomycin A - CAS 7059-24-7 - Calbiochem
Packaging
10mg
Price
$250.67
Updated
2021/03/22
Alfa Aesar
Product number
J62927
Product name
Chromomycin A3, 97%
Packaging
10mg
Price
$342
Updated
2021/12/16
Cayman Chemical
Product number
11315
Product name
Chromomycin A3
Purity
≥98%
Packaging
1mg
Price
$48
Updated
2021/12/16
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CHROMOMYCIN A3 Chemical Properties,Usage,Production

Description

Chromomycin A3 is an anthraquinone antibiotic and antitumor agent isolated from S. griseus that is used as a fluorescent probe for DNA with excitation/emission spectra of 445/575 nm. Its DNA binding is specific to two or more contiguous GC base pairs, which makes it suitable for characterizing heterochromatin in plants with species-specific AT:GC ratios. Chromomycin A3 is cytotoxic against non-small cell lung cancer and cervical cancer in vitro (IC50s = 1, 42, 60, and 40 nM for HCC44, A549, ME180, and HeLa cells, respectively). It also inhibits oxidative stress- and DNA damage-induced neuronal injury by enhancing Sp1 and Sp3 transcription factor binding.

Chemical Properties

Yellow powder

Uses

Chromomycin A3 is the major component of the chromomycin complex of the aureolic acid class, isolated from several Streptomyces species, and first reported in 1960. Chromomycin A3 exhibits a broad biological profile as an antibacterial, antifungal and antitumour agent. It binds reversibly to GC-specific DNA ligand in the minor groove which inhibits transcription, DNA gyrase and topoisomerase II activity. The intense UV spectrum and strong fluorescence makes chromomycin a useful stain for DNA.

Uses

Fluorescent DNA stain in flow cytometry and karyotype analysis of chromosomes.

Uses

Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate "G-C" box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.

General Description

Chemical structure: aureolic acid

Biochem/physiol Actions

Chromomycin A3 from Streptomyces griseus is an antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. It serves as a fluorescent DNA stain. It is useful for the detection of protamine deficiency in sperm chromatin. The compound blocks macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.

Purification Methods

Dissolve the antibiotic (10g) in EtOAc and add to a column of Silica Gel (Merck 0.05-0.2microns, 4x70cm) in EtOAc containing 1% oxalic acid. Elute with EtOAc+1% oxalic acid and check fractions by TLC. Pool fractions, wash with H2O thoroughly, dry and evaporate. Recrystallise the residue from EtOAc. The heptaacetate has m 214o, [] D -20o (c 1, EtOH). [Miyamoto et al. Tetrahedron 23 421 1967, Harada et al. J Am Chem Soc 91 5896 1969, Beilstein 17/5 V 673.]

CHROMOMYCIN A3 Preparation Products And Raw materials

Raw materials

Preparation Products

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CHROMOMYCIN A3 Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
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76
Jinxiang Chemical (Danyang) Products Co., Ltd.
Tel
025-86819862
Fax
0086-25-86819859
Email
nancyzong@jinchemical.com
Country
China
ProdList
97
Advantage
74
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399-
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4575
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
26481
Advantage
56
Sigma-Aldrich
Tel
021-61415566- ;
Email
orderCN@merckgroup.com;orderCN@merckgroup.com
Country
China
ProdList
50837
Advantage
80
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312824-
Fax
QQ:3008007432
Email
3008007432@qq.com
Country
China
ProdList
30311
Advantage
60
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840-
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12313
Advantage
58
Lynnchem
Tel
029-85992781-
Email
info@lynnchem.com
Country
China
ProdList
4465
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58
Novachemistry
Tel
44-20819178-90
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4384
Advantage
58
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-85201366-
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9504
Advantage
58
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View Lastest Price from CHROMOMYCIN A3 manufacturers

Dideu Industries Group Limited
Product
CHROMOMYCIN A3 USP/EP/BP 7059-24-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Longyan Tianhua Biological Technology Co., Ltd
Product
CHROMOMYCIN A3 7059-24-7
Price
US $12.00/Kg/Bag
Min. Order
25Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2020-11-17
Shaanxi Dideu Medichem Co. Ltd
Product
ChroMoMycin A3 7059-24-7
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

7059-24-7, CHROMOMYCIN A3Related Search:


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