CHROMOMYCIN A3

ChemicalBook > CAS DataBase List > CHROMOMYCIN A3

Product Name: CHROMOMYCIN A3
CAS No.: 7059-24-7
Chemical Name: CHROMOMYCIN A3
Synonyms: TOYOMYCIN;nsc-58514;Chromomycin;aburamycinb;Olivomycin D;CHROMOMYCIN A3;Chromoycin A3;antibioticb599;ABURAMYCIN BETA;nosyl)-7-methyl-
CBNumber: CB8356277
Molecular Formula: C57H82O26
Formula Weight: 1183.25
MOL File: 7059-24-7.mol

Less

CHROMOMYCIN A3 Property

Melting point:: 185℃
alpha: D23 -57° (ethanol)
Boiling point:: 780.13°C (rough estimate)
Density: 1.1451 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: 2-8°C
solubility: Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml).
form: Yellow solid
pka: 4.54±0.60(Predicted)
color: Yellow
Merck: 13,2258
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Less

Safety

Hazard Codes: T+,T
Risk Statements: 61-28
Safety Statements: 53-28-36/37/39-45
RIDADR: UN 3462 6.1/PG 1
WGK Germany: 3
RTECS: GB7875000
F: 3-8-10
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 29419090
Toxicity: Excitation max: ~445 nm. Emission max: ~575 nm. Sol in ethanol, ethyl acetate, DMSO, methanol. LD50 in mice (mg/kg): 1.85 i.v. (Slavik, Carter).

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C2659
Product name: Chromomycin A3 from Streptomyces griseus
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $297
Updated: 2024/03/01

Sigma-Aldrich

Product number: C2659
Product name: Chromomycin A3 from Streptomyces griseus
Purity: ≥95% (HPLC)
Packaging: 10mg
Price: $497
Updated: 2024/03/01

Alfa Aesar

Product number: J62927
Product name: Chromomycin A3, 97%
Packaging: 10mg
Price: $388.65
Updated: 2024/03/01

Cayman Chemical

Product number: 11315
Product name: Chromomycin A3
Purity: ≥98%
Packaging: 1mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 11315
Product name: Chromomycin A3
Purity: ≥98%
Packaging: 5mg
Price: $138
Updated: 2024/03/01

Less

CHROMOMYCIN A3 Chemical Properties,Usage,Production

Description

Chromomycin A₃ is an anthraquinone antibiotic and antitumor agent isolated from S. griseus that is used as a fluorescent probe for DNA with excitation/emission spectra of 445/575 nm. Its DNA binding is specific to two or more contiguous GC base pairs, which makes it suitable for characterizing heterochromatin in plants with species-specific AT:GC ratios. Chromomycin A₃ is cytotoxic against non-small cell lung cancer and cervical cancer in vitro (IC₅₀s = 1, 42, 60, and 40 nM for HCC44, A549, ME180, and HeLa cells, respectively). It also inhibits oxidative stress- and DNA damage-induced neuronal injury by enhancing Sp1 and Sp3 transcription factor binding.

Chemical Properties

Yellow powder

Uses

Chromomycin A3 is the major component of the chromomycin complex of the aureolic acid class, isolated from several Streptomyces species, and first reported in 1960. Chromomycin A3 exhibits a broad biological profile as an antibacterial, antifungal and antitumour agent. It binds reversibly to GC-specific DNA ligand in the minor groove which inhibits transcription, DNA gyrase and topoisomerase II activity. The intense UV spectrum and strong fluorescence makes chromomycin a useful stain for DNA.

Uses

Chromomycin A3, is used as a G-C specific DNA ligand which inhibits transcription and acts as a DNA binding dye. Chromomycin A3 antagonizes enhanced DNA binding of the transcription factors Sp1 and Sp3 to their cognate "G-C" box, induced by oxidative stress or DNA damage. Furthermore, by inhibiting transcription, Chromomycin A3 and its structural analogs can inhibit protein biosynthesis.

Uses

Fluorescent DNA stain in flow cytometry and karyotype analysis of chromosomes.

Definition

ChEBI: Chromomycin A3 is a chromomycin.

General Description

Chemical structure: aureolic acid

Biochem/physiol Actions

Chromomycin A3 from Streptomyces griseus is an antibiotic exhibiting anti-bacterial, anti-fungal and antitumor activities. It serves as a fluorescent DNA stain. It is useful for the detection of protamine deficiency in sperm chromatin. The compound blocks macromolecule synthesis by a specific, reversible interaction with DNA in the presence of bivalent metal ions. Binding to DNA minor groove mediates an efficient competitive inhibition of DNA gyrase and significantly affects topoisomerase II activity.

Purification Methods

Dissolve the antibiotic (10g) in EtOAc and add to a column of Silica Gel (Merck 0.05-0.2microns, 4x70cm) in EtOAc containing 1% oxalic acid. Elute with EtOAc+1% oxalic acid and check fractions by TLC. Pool fractions, wash with H2O thoroughly, dry and evaporate. Recrystallise the residue from EtOAc. The heptaacetate has m 214o, [] D -20o (c 1, EtOH). [Miyamoto et al. Tetrahedron 23 421 1967, Harada et al. J Am Chem Soc 91 5896 1969, Beilstein 17/5 V 673.]

References

Van Dyke et al. (1983), Chromomycin, Mithramycin and olivomycin binding sites on heterogeneous deoxyribonucleic acid. Footprinting with methidiumpropyl-EDTA)iron(II); ?Biochemistry, 22 2373 Crissman and Tobey (1990), Specific staining of DNA with the fluorescent antibiotic, mithramycin, chromomycin, and olivomycin; Methods Cell Biol., 33 97 Chatterjee et al. (2001), Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons; Neurol., 49 345 Miller et al. (2010), Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action; Pharmacol., 79 1272 Dutta et al. (2020), Comparative analysis of tests used to assess sperm chromatin integrity and DNA fragmentation; Andrologia, 53?e13718

CHROMOMYCIN A3 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

CHROMOMYCIN A3 Suppliers

China 70 Germany 4 India 1 Japan 1 Switzerland 2 United Kingdom 8 United States 17 Global 103

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Jinxiang Chemical (Danyang) Products Co., Ltd.

Tel: 025-86819862 13913839793
Fax: 0086-25-86819859
Email: nancyzong@jinchemical.com
Country: China
ProdList: 97
Advantage: 74

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

JIANGYIN RUISHIPHARM CO.,LIMITED

Tel: 0510-0510-66227179 18921203887
Fax: +86-0510-66227179 QQ:2200317867
Email: sales@ruishipharm.com
Country: China
ProdList: 751
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418671
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34572
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 29474
Advantage: 58

Longyan Tianhua Biological Technology Co., Ltd

Tel: 0086 18039857276 18039857276
Country: CHINA
ProdList: 2783
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5182
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22968
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 15093356674;
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29826
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569266 15319487004
Fax: 029-88380327
Email: 1015@dideu.com
Country: China
ProdList: 2263
Advantage: 58

Fuxin Pharmaceutical

Tel: +86-021-021-50872116 +8613122107989
Email: contact@fuxinpharm.com
Country: China
ProdList: 10297
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-61856359 18690052321
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 9927
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8864
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 13626641628
Email: jiangnan@huidabiotech.com
Country: China
ProdList: 3661
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 13675144456
Fax: 025-85563444
Email: sean.lv@synzest.com
Country: China
ProdList: 11442
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4576
Advantage: 58

Hubei Zhongshan Medical Technology Co., Ltd

Tel: 027-61907345 13397111514
Fax: 3443707954
Email: w13397111514@163.com
Country: China
ProdList: 1011
Advantage: 58

Shanghai kadel chemical technology co., LTD

Tel: 021-4007787-550 400-7787-550
Email: 2850202386@qq.com
Country: China
ProdList: 10618
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223
Email: psaitong@jm-bio.com
Country: China
ProdList: 29834
Advantage: 58

Guangzhou Yunmen Biotechnology Co., Ltd

Tel: 18902340307 18902340307
Fax: 0751-2819901
Email: 3356812514@qq.com
Country: China
ProdList: 9238
Advantage: 58

Zhejiang Huida Biotech Co., LTD

Tel: 0571-0571-89903882 15990081639
Email: sunshixuan@huidabiotech.com
Country: China
ProdList: 3705
Advantage: 58

Wuhan Augda Biotechnology Co., Ltd

Tel: 15071299552
Fax: QQ:262933239
Email: 262933239@qq.com
Country: China
ProdList: 6637
Advantage: 58

Shanghai klamar Reagent Co., LTD

Tel: 4001650900 13817534909
Email: 3003940895@qq.com
Country: China
ProdList: 9345
Advantage: 58

Guangdong Fangxin Biotechnology Co., Ltd.

Tel: 0751-2838688 13376594225
Email: 1276075424@qq.com
Country: China
ProdList: 9933
Advantage: 58

Guangzhou Yaoguang Technology Co., Ltd.

Tel: 13020159086
Email: yangjue@ygfuture.com
Country: China
ProdList: 481
Advantage: 58

Shanghai Yanchun Biopharmaceutical Technology Co., Ltd

Tel: 4001-009266 17349750668
Email: product@sci-e.com
Country: China
ProdList: 2812
Advantage: 58

Cheng Du Micxy Chemical Co.,Ltd

Tel: 028-85632863 18048500443
Fax: 028-85632863
Email: sales@micxy.com
Country: China
ProdList: 10476
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12007
Advantage: 58

Henan Tianfu Chemical Co.,Ltd.

Tel: +86-0371-55170693 +86-19937530512
Fax: 0371-55170693
Email: info@tianfuchem.com
Country: China
ProdList: 21695
Advantage: 55

Wuhan Topule Biopharmaceutical Co., Ltd

Tel: +8618327326525
Email: masar@topule.com
Country: China
ProdList: 8474
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Dongguan Biaobiao Experimental Equipment Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6673
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6172
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: market@xlswkj.com
Country: CHINA
ProdList: 6805
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6039
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6192
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6530
Advantage: 58

Beijing Shengke Boyuan Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 978560024@qq.com
Country: CHINA
ProdList: 6011
Advantage: 58

Wuhan Boot Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6829
Advantage: 58

Guangzhou Weijia Technology Co., Ltd.

Tel: --
Fax: --
Email: WHIGA22@126.COM
Country: CHINA
ProdList: 6748
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6979
Advantage: 58

Less

View Lastest Price from CHROMOMYCIN A3 manufacturers

Dideu Industries Group Limited

Product: CHROMOMYCIN A3 7059-24-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-01

Longyan Tianhua Biological Technology Co., Ltd

Product: CHROMOMYCIN A3 7059-24-7
Price: US $12.00/Kg/Bag
Min. Order: 25Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-11-17

Shaanxi Dideu Medichem Co. Ltd

Product: ChroMoMycin A3 7059-24-7
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

7059-24-7, CHROMOMYCIN A3Related Search:

AburaMycin A, NSC 131187 6-Methoxy-2-naphthaldehyde 5-Hydroxy-4-octanone 2,3,6-TRIMETHYLNAPHTHALENE 6'-Methoxy-2'-propiononaphthone ISOVALEROPHENONE Naphthalen-2-ethanol 6-Methoxy-2-heptanonaphthone CHROMOMYCIN A3 2,6-DIMETHYLNAPHTHALENE 5,6,7,8-TETRAHYDRO-1-NAPHTHOL 2-Acetyl-6-methoxynaphthalene 2,6-HEPTANEDIONE 1,6-Dihydroxynaphthalene 2,3-DIMETHYLNAPHTHALENE 6-Hydroxy-2-naphthaldehyde 2,7-DIMETHYLNAPHTHALENE (R)-(-)-4-PHENYL-2-BUTANOL

chromomycina(sub3)

nosyl)-7-methyl-

nsc-58514

olivomycind,3b-o-(4-o-acetyl-2,6-dideoxy-3-c-methyl-alpha-l-arabinohexopyra

TOYOMYCIN

3BETA-O-(4-O-ACETYL-2.6-DIDEOXY-3-C-METHYL-ALPHA-L-ARABINO HEXOPYRANOSYL)-7-METHYLOLIVOMYCIN D

3B-O-(4-O-ACETYL-2,6-DIDEOXY-3-C-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSYL)-7-METHYLOLIVOMYCIN D

3B-O-(4-O-ACETYL-2,6-DIDEXY-3-C-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSYL)-7-METHYLOLIVOMYCIN

ABURAMYCIN BETA

CHROMOMYCIN A3

CHROMOMYCIN A3 STREPTOMYCES GRISEUS

3D-O-(4-O-acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methylolivomycin D

CHROMOMYCIN A(3), FOR FLUORESCENCE

CHROMOMYCIN A3 FROM STREPTOMYCESGRISEUS APPROX. 96

Chromomycin

D-threo-2-Pentulose, 1-C-(2S,3S)-7-4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-.alpha.-D-lyxo-hexopyranosyl)-.beta.-D-lyxo-hexopyranosyloxy-3-O-4-O-acetyl-2,6-dideoxy-3-C-methyl-.alpha.-L-arabino-hexopyranosyl-(1?3)-O-2,6-dideoxy-.beta.-D-arabino-h

chromomycin a3from streptomyces griseus

3'''-O-(4-O-Acetyl-3-C-methyl-2,6-dideoxy-α-L-arabino-hexopyranosyl)-7-methylolivomycin D

Chromoycin A3

Olivomycin D

AburaMycin, ToyoMycin, NSC 58514, B 599-III, SR1768E

aburamycinb

Chromomycin A - CAS 7059-24-7 - Calbiochem

[(2R,3S,4R,6S)-6-[[(6S,7S)-6-[(2S,4R,5R,6R)-4-[(2S,4R,5R,6R)-4-[(2S,4S,5S,6S)-5-acetyloxy-4-hydroxy-4,6-dimethyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-7-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-4,10-dihydroxy-3-methyl-5-oxo-7,8-dihydro-6H-anthracen-2-yl]oxy]-4-[(2R,4R,5R,6R)-4-hydroxy-5-methoxy-6-methyloxan-2-yl]oxy-2-methyloxan-3-yl] acetate

antibiotic69895a

antibioticb599

D-threo-2-Pentulose, 1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy...

CHROMOMYCIN A3 USP/EP/BP

7059-24-7

C57H82O26

Antibiotics

Antibiotics A to Z

Antibiotics A-F

BioChemical

antibiotic