CHAETOGLOBOSIN A

Product Name: CHAETOGLOBOSIN A
CAS No.: 50335-03-0
Chemical Name: CHAETOGLOBOSIN A
Synonyms: CHAETOGLOBOSIN;CHAETOGLOBOSINL;CHAETOGLOBOSINE;CHAETOGLOBOSINM;CHAETOGLOBOSINB;chaetoglobosins;CHAETOGLOBOSIN A;CHAETOGLOBOSIN A, B, C, D, E, F, K, Q, R, T;18-dimethyl-,(7s,13e,16s,17e,19r,21e)-ol-3-yl)-1;3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione
CBNumber: CB8359122
Molecular Formula: C32H36N2O5
Formula Weight: 528.64
MOL File: 50335-03-0.mol

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CHAETOGLOBOSIN A Property

Melting point:: 188°C
Boiling point:: 608.81°C (rough estimate)
Density: 1.1705 (rough estimate)
refractive index: 1.5800 (estimate)
storage temp.: -20°C
solubility: DMSO: soluble10mg/mL
form: solid
pka: 17.32±0.30(Predicted)
color: Yellow
Stability:: Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

WGK Germany: 3
HS Code: 2941900000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0642
Product name: Chaetoglobosin A
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $397
Updated: 2024/03/01

Cayman Chemical

Product number: 19405
Product name: Chaetoglobosin A
Purity: ≥98%
Packaging: 1mg
Price: $113
Updated: 2024/03/01

Cayman Chemical

Product number: 19405
Product name: Chaetoglobosin A
Purity: ≥98%
Packaging: 5mg
Price: $421
Updated: 2024/03/01

Tocris

Product number: 5804
Product name: Chaetoglobosin A
Purity: ≥98%(HPLC)
Packaging: 1
Price: $168
Updated: 2021/12/16

TRC

Product number: C291838
Product name: Chaetoglobosin A
Packaging: 2.5mg
Price: $295
Updated: 2021/12/16

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CHAETOGLOBOSIN A Chemical Properties,Usage,Production

Description

Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3

Occurrence

A complex macrocyclic alkaloid, this base has been isolated from Diplodia rnacrospora. Chaetoglobosin A possesses the property of inhibiting growth in wheat coleoptiles.

Uses

Chaetoglobosin A is a mycotoxic cytochalasan compound.

Definition

ChEBI: A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.

storage

+4°C

References

1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734 2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289 3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262

CHAETOGLOBOSIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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CHAETOGLOBOSIN A Suppliers

China 34 Germany 2 India 1 Switzerland 1 United Kingdom 4 United States 8 Global 50

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50335-03-0, CHAETOGLOBOSIN ARelated Search:

Geldanamycin CYCLOPAMINE S-Trityl-L-cysteine AAL-993 Nisin CHAETOGLOBOSIN A valdetamide

CHAETOGLOBOSINB

CHAETOGLOBOSINM

CHAETOGLOBOSINE

CHAETOGLOBOSINL

(13)cytochalasa-13,17,21-triene-1,20,23-trione,6,7-epoxy-19-hydroxy-10-(1h-ind

18-dimethyl-,(7s,13e,16s,17e,19r,21e)-ol-3-yl)-1

chaetoglobosins

CHAETOGLOBOSIN

CHAETOGLOBOSIN A

CHAETOGLOBOSIN A, B, C, D, E, F, K, Q, R, T

3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione

4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-

(1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-4,7,14,14a,15,15a,16a,16b-Octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-3H-cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione

3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione, 4,7,14,14a,15,15a,16a,16b-octahydro-7-hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-, (1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-

50335-03-0

Antibiotic