CHAETOGLOBOSIN A
- Product Name
- CHAETOGLOBOSIN A
- CAS No.
- 50335-03-0
- Chemical Name
- CHAETOGLOBOSIN A
- Synonyms
- CHAETOGLOBOSIN;CHAETOGLOBOSINL;CHAETOGLOBOSINE;CHAETOGLOBOSINM;CHAETOGLOBOSINB;chaetoglobosins;CHAETOGLOBOSIN A;CHAETOGLOBOSIN A, B, C, D, E, F, K, Q, R, T;18-dimethyl-,(7s,13e,16s,17e,19r,21e)-ol-3-yl)-1;3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione
- CBNumber
- CB8359122
- Molecular Formula
- C32H36N2O5
- Formula Weight
- 528.64
- MOL File
- 50335-03-0.mol
CHAETOGLOBOSIN A Property
- Melting point:
- 188°C
- Boiling point:
- 608.81°C (rough estimate)
- Density
- 1.1705 (rough estimate)
- refractive index
- 1.5800 (estimate)
- storage temp.
- -20°C
- solubility
- DMSO: soluble10mg/mL
- form
- solid
- pka
- 17.32±0.30(Predicted)
- color
- Yellow
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety
- WGK Germany
- 3
- HS Code
- 2941900000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- SML0642
- Product name
- Chaetoglobosin A
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $397
- Updated
- 2024/03/01
- Product number
- 19405
- Product name
- Chaetoglobosin A
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- 19405
- Product name
- Chaetoglobosin A
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $421
- Updated
- 2024/03/01
- Product number
- 5804
- Product name
- Chaetoglobosin A
- Purity
- ≥98%(HPLC)
- Packaging
- 1
- Price
- $168
- Updated
- 2021/12/16
- Product number
- C291838
- Product name
- Chaetoglobosin A
- Packaging
- 2.5mg
- Price
- $295
- Updated
- 2021/12/16
CHAETOGLOBOSIN A Chemical Properties,Usage,Production
Description
Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3
Occurrence
A complex macrocyclic alkaloid, this base has been isolated from Diplodia rnacrospora. Chaetoglobosin A possesses the property of inhibiting growth in wheat coleoptiles.
Uses
Chaetoglobosin A is a mycotoxic cytochalasan compound.
Definition
ChEBI: A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.
storage
+4°C
References
1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734 2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289 3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262