Amygdalin
Uses and Synthetic Methods of Amygdalin Category Toxicity classification Acute toxicity Flammability Hazardous properties Storage and transportation Fire extinguishing agent- Product Name
- Amygdalin
- CAS No.
- 29883-15-6
- Chemical Name
- Amygdalin
- Synonyms
- D-AMYGDALIN;vitamin b17;Bitter AlMond extract;D(-)-AMYGDALIN;LAETRILE;D,L-AMYGDALIN;D-AMYGDALIN HYDRATE;(r)-alpha-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)benzeneaceto;(r)-alpha-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)benzeneacetonit;rile
- CBNumber
- CB8363552
- Molecular Formula
- C20H27NO11
- Formula Weight
- 457.43
- MOL File
- 29883-15-6.mol
Amygdalin Property
- Melting point:
- 223-226 °C
- alpha
- -38.5 º (c=4, H2O)
- Boiling point:
- 563.27°C (rough estimate)
- Density
- 1.4474 (rough estimate)
- refractive index
- -40 ° (C=2, H2O)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- H2O: 0.1 g/mL hot, clear to very faintly turbid, colorless
- pka
- 12.69±0.70(Predicted)
- form
- Powder
- color
- White to Off-white
- optical activity
- [α]20/D 39±2°, c = 2% in H2O
- Water Solubility
- 83 g/L (25 ºC)
- Merck
- 14,597
- BRN
- 66856
- Stability:
- Hygroscopic
- InChIKey
- XUCIJNAGGSZNQT-SWRVSKMJSA-N
- LogP
- -2.237 (est)
- CAS DataBase Reference
- 29883-15-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 26-36/37/39-45-24/25
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- OO8450000
- F
- 10-21
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29389090
- Hazardous Substances Data
- 29883-15-6(Hazardous Substances Data)
- Toxicity
- LD50 orl-rat: 522 mg/kg WJMDA2 134,97,81
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10050
- Product name
- Amygdalin
- Purity
- BioXtra, ≥97.0% (HPLC)
- Packaging
- 5g
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 10050
- Product name
- Amygdalin
- Purity
- BioXtra, ≥97.0% (HPLC)
- Packaging
- 25g
- Price
- $419
- Updated
- 2024/03/01
- Product number
- A0443
- Product name
- Amygdalin
- Purity
- >97.0%(HPLC)
- Packaging
- 1g
- Price
- $28
- Updated
- 2024/03/01
- Product number
- J61472
- Product name
- D-Amygdalin, 98%
- Packaging
- 1g
- Price
- $30.65
- Updated
- 2024/03/01
- Product number
- J61472
- Product name
- D-Amygdalin, 98%
- Packaging
- 5g
- Price
- $77.65
- Updated
- 2024/03/01
Amygdalin Chemical Properties,Usage,Production
Uses and Synthetic Methods of Amygdalin
Amygdalin is a β-cyano-glycoside in the bitter almond that is bound to cyano (CN), which releases free cyano groups after eating the bitter almond, so that the food is poisoned. Amygdalin is a product of the metabolism of phenylalanine in the bitter almond. Amygdalin has β-glucosidase and amygdalinase (oxynitrilase): the former catalyzed amygdalin into two molecules of glucose and one molecule of amygdalenone through hydrolysis; the later catalyzes mandelonitrile into almond nitrile cyanide (HCN) and benzaldehyde through hydrolysis. Amygdalin exists in seeds, such as almonds.
Many plant root cells contain glycosides, with no toxic effect when in sugar type. Glycosides hydrolysis produce toxic substances leading to cell death. Mandelic glycosides contained in peach root is a glycoside. Amylose hydrolysis produce two kinds of plant toxins-hydrogen cyanide and benzaldehyde. Peeling root lesion formation and necrosis occurred in the vicinity of the stabbed nematode but not in contact zone; in addition, in vitro tests have proved that the pratylenchus penetrans can make amygdalin hydrolysis.
As a cyanide containing glucoside, it can be used as a substrate for such as maltase, almond casein and β-glucosidase identification, differentiation and characterization.
Category
Toxic substances
Toxicity classification
Highly toxic
Acute toxicity
Acute toxicity Oral-Rat LD50: 522 mg/kg; Oral-mouse LD50: 443 mg/kg
Flammability Hazardous properties
Combustible; producing toxic nitrogen oxides when heated.
Storage and transportation
Ventilation, low temperature, drying
Fire extinguishing agent
Dry powder, foam, sand, carbon dioxide
Description
Amygdalin is a cyanogenic glycoside that has been found in seeds from plants of the Rosaceae family and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase, decreases cyclin A and Cdk2 levels, and inhibits cell growth in UMUC-3, RT112, and TCCSUP bladder cancer cells when used at concentrations ranging from 1.25 to 10 mg/ml. Amygdalin (3 mg/kg) reduces the number of primary microtubules and microvessels in aortic rings isolated from rats with diabetes induced by streptozotocin . In vivo, amygdalin reduces triglyceride, total cholesterol, and LDL levels and aortic sinus plaque area in an LDLR-/- mouse model of atherosclerosis. It also reduces production of TNF-α, IL-1β, and IL-6, as well as neutrophil and macrophage infiltration, in bronchoalveolar lavage fluid (BALF) in a mouse model of LPS-induced acute lung injury.
Chemical Properties
WHITE FINE CRYSTALLINE POWDER
Uses
antiinflammatory, experimental antineoplastic
Uses
Amygdalin, a cyanide containing glycoside, may be used as a substrate to identify, differentiate and characterize enzymes such as maltase(s), emulsin(s) and β-glucosidase(s).
Uses
A cyanogenic glycoside occurring in seeds of Rosaceae, principally in bitter almonds and peach and apricot pits. Some time ago it was said to be effective in the treatment of cancer, but controlled clinical trials repeatedly failed to confirm such claims.
Definition
ChEBI: An amygdalin in which the stereocentre on the cyanohydrin function has R-configuration.
World Health Organization (WHO)
Laetrile, which consists mainly of amydgalin, a glycoside extracted from the kernels of apricots, peaches and other fruits, has been available for over 30 years in preparations purporting to be beneficial in the treatment of cancer. Although there is no evidence that these are efficacious, preparations continued to be widely used and, until the late 1970s, they were considered to be harmless. However, oral dosage forms, which may be broken down in the gut to hydrogen cyanide, have subsequently been shown to be potentially lethal. This has resulted in restrictive regulatory measures in several countries.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Cyanogenic glycoside that is a component of bitter almonds and apricot pits. There is no scientific evidence that amygdalin itself is an effective anti-cancer agent. Recent studies using β?glucoside linked to a tumor-associated monoclonal antibody to release cyanide at the tumor cell has shown significant cytotoxicity.
Safety Profile
Human poison by ingestion(infant data). Poison experimentally by ingestion. Anexperimental teratogen. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
Purification Methods
D-Amygdalin recrystallises from water as the trihydrate, or from EtOH. It is present in bitter almonds. [Smith Chem Ber 64 1115 1931, Beilstein 17/8 V 188.]
Amygdalin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Amygdalin manufacturers
- Product
- Vitamin B17 / Amygdalin 29883-15-6
- Price
- US $180.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-23
- Product
- Amygdalin 29883-15-6
- Price
- US $270.00-260.00/kg
- Min. Order
- 1kg
- Purity
- 98% HPLC
- Supply Ability
- no limitation
- Release date
- 2023-02-21
- Product
- vitamin B17 29883-15-6
- Price
- US $275.00-245.00/kg
- Min. Order
- 1kg
- Purity
- 98% HPLC
- Supply Ability
- 1000
- Release date
- 2023-04-26