ChemicalBook > CAS DataBase List > DFMO

DFMO

Product Name
DFMO
CAS No.
70052-12-9
Chemical Name
DFMO
Synonyms
DIFLUOROMETHYLORNITHINE;DFMO;RFI 71782;Ccris 3295;Brn 2250529;EFLORNITINE;DL-EFLORNITHINE;H-DL-(F2ME)ORN-OH;α-Difluoromethylornitine;α-difluoromethylornithine
CBNumber
CB8373227
Molecular Formula
C6H12F2N2O2
Formula Weight
182.17
MOL File
70052-12-9.mol
More
Less

DFMO Property

Melting point:
138 °C
Boiling point:
347.0±42.0 °C(Predicted)
Density 
1.1800 (estimate)
storage temp. 
Store at 0°C
solubility 
H2O: >10 mg/mL, soluble
form 
solid
pka
1.22±0.44(Predicted)
color 
white
More
Less

Safety

WGK Germany 
3
Hazardous Substances Data
70052-12-9(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D193
Product name
DL-α-Difluoromethylornithine hydrochloride hydrate
Purity
solid, ≥97% (NMR)
Packaging
25mg
Price
$241
Updated
2024/03/01
Sigma-Aldrich
Product number
D193
Product name
DL-α-Difluoromethylornithine hydrochloride hydrate
Purity
solid, ≥97% (NMR)
Packaging
100mg
Price
$724
Updated
2024/03/01
Tocris
Product number
2761
Product name
DFMO
Packaging
50
Price
$324
Updated
2021/12/16
Tocris
Product number
2761
Product name
DFMO
Packaging
10
Price
$75
Updated
2021/12/16
Usbiological
Product number
255132
Product name
DFMO
Packaging
10mg
Price
$310
Updated
2021/12/16
More
Less

DFMO Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Uses

DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.

Definition

ChEBI: Eflornithine is a fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. It has a role as a trypanocidal drug. It is a fluoroamino acid and an alpha-amino acid. It is functionally related to an ornithine.

General Description

Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues.

Biological Activity

Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity.

Biochem/physiol Actions

Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.

DFMO Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

DFMO Suppliers

China 44 Germany 1 India 2 Switzerland 1 United Kingdom 3 United States 13 Global 64
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1494
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9798
Advantage
50
Hefei NaNo Biological Technology Co., Ltd.
Tel
0551-65629887 18010855303
Fax
0551-65629887
Email
sales@hfnhsw.com
Country
China
ProdList
262
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Shenzhen Chim Biotech Co., Ltd.
Tel
0755-36320761 13692196024
Fax
0755-28364769
Email
sales@chimchem.com
Country
China
ProdList
501
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28822
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15085
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 18521078705
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
20044
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
6912
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25363
Advantage
58
Nextpeptide Inc
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19915
Advantage
58
Shanghai Youde Chemical Technology Co., Ltd.
Tel
021-37910267 15821801668
Email
sales@udchem.com
Country
China
ProdList
1218
Advantage
58
Wuhan Xinru Chemical Co., Ltd.
Tel
15927387915 15337108568
Email
2769903731@qq.com
Country
China
ProdList
3338
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7953
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44490
Advantage
58
Hubei yongkuo Technology Co., Ltd
Tel
027-59223108 15972152991
Fax
027-59223108
Email
1248580099@qq.com
Country
China
ProdList
10007
Advantage
58
Hubei Baidu Chemical Co., Ltd
Tel
13627137652
Fax
027-59223020
Email
1438180055@qq.com
Country
China
ProdList
9994
Advantage
58
Tianmen Hengchang Chemical Co., Ltd
Tel
027-59322316 15172518801
Fax
027-59322316
Email
1208480077@qq.com
Country
China
ProdList
9944
Advantage
58
Hubei xingongli Chemical Co., Ltd
Tel
027-59503710 15172325309
Fax
027-59503710
Email
1400858877@qq.com
Country
China
ProdList
9965
Advantage
58
Sanover (Xiamen) Technology Co., Ltd
Tel
059265188632; 13876246362
Fax
QQ : 422165847
Email
422165847@qq.com
Country
China
ProdList
509
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29834
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
18768175414
Email
gaojun@univ-bio.com
Country
China
ProdList
24998
Advantage
58
Wuhan Augda Biotechnology Co., Ltd
Tel
15071299552
Fax
QQ:262933239
Email
262933239@qq.com
Country
China
ProdList
6637
Advantage
58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
Tel
+86-027-59232304 15387063101
Email
2881924050@qq.com
Country
China
ProdList
9991
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29803
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27996
Advantage
58
Qiyuan (Guangdong) Pharmaceutical Chemical Co., Ltd.
Tel
400-666-9280 18026564465
Email
304903156@qq.com
Country
China
ProdList
8011
Advantage
58
Hubei Enxing Biotechnology Co., Ltd
Tel
16621771607
Email
exbio_tech@163.com
Country
China
ProdList
8359
Advantage
58
Shaanxi Xihua Chemical Industry Co., Ltd
Tel
17691182729 15529505138
Email
1021@dideu.com
Country
China
ProdList
10011
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48570
Advantage
58
Shanghai jerryxing Biomedical Technology Co., Ltd
Tel
17721492509
Email
643638326@qq.com
Country
China
ProdList
5347
Advantage
58
RD International Technology Co., Limited
Tel
18988968278
Email
sales@ubiochem.com
Country
China
ProdList
9146
Advantage
58
LEAPCHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
43348
Advantage
58
Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
Country
China
ProdList
8474
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1985563437@qq.com
Country
CHINA
ProdList
6172
Advantage
58
Boao Pike
Tel
--
Fax
--
Email
lyn@biopike.com.cn
Country
CHINA
ProdList
6629
Advantage
58
Guangzhou WeiBo Chemical Co., Ltd.
Tel
--
Fax
--
Email
weibochem@163.com
Country
China
ProdList
6187
Advantage
67
Hangzhou Heta Pharm & Chem Co., Ltd
Tel
--
Fax
--
Email
sales@hetapharm.com
Country
China
ProdList
133
Advantage
54

70052-12-9, DFMORelated Search:

3-Hydroxyphenyl acetate racephedrine Acetonitrile DFMO DFMO-PCV protocol DFMO EFLORNITHINE (S)-2-AMINO-2-METHYLBUTYRIC ACID BETA-FLUORO-DL-ALANINE 2,5-DIAMINO-2-METHYL-PENTANOIC ACID HCL DFMO DFMO,DFMO HCL,DFMO HYDROCHLORIDE DFMO 2-FLUORO-1,1-DIMETHYL-ETHYLAMINE HCL-SALT

  • 96020-91-6 (Mono-hydrochloride, monohydrate)
  • alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid
  • Brn 2250529
  • Ccris 3295
  • DL-2-(Difluoromethyl)-ornithinehydrochloride
  • DL-α-Difluoromethylornithine hydrochloride hydrate,2-(Difluoromethyl)ornithine hydrochloride hydrate, DFMO hydrochloride hydrate, Eflornithine hydrochloride hydrate
  • DIFLUOROMETHYLORNITHINE(RG)
  • α-Difluoromethyl-DL-ornithine
  • DFMO hydrochloride hydrate
  • DL-α-Difluoromethylornithine hydrochloride hydrate
  • RFI 71782
  • DL-2-(DIFLUORO-METHYL)-ORNITHINE HCL
  • DL-(α-difluoromethyl)Orn-OH
  • α-Difluoromethyl-DL-ornithine≥ 98% (NMR)
  • 2-(difluoromethyl)-ornithin
  • alpha-difluoromethylornithine
  • alpha-difluromethylornithine
  • ALPHA-DIFLUORO-ME-DL-ORNITHINE
  • ALPHA-DIFLUOROMETHYL-DL-ORNITHINE
  • 2-(Difluoromethyl)ornithine hydrate hydrochloride, DFMO hydrate hydrochloride
  • DL-α-Difluoromethylornithine hydrate hydrochloride
  • 2-(Difluoromethyl)-2,5-diaminovaleric acid
  • α-Difluoromethylornitine
  • DL-α-Difluoromethylornithine hydrochloride
  • H-DL-(ALPHA-DIFLUOROMETHYL)ORN-OH
  • H-DL-(F2ME)ORN-OH
  • H-ALPHA-DIFLUORO-ME-DL-ORN-OH
  • EFLORNITINE
  • DL-ALPHA-DIFLUOROMETHYLORNITHINE
  • DFMO
  • DIFLUOROMETHYLORNITHINE
  • DL-ALPHA-DIFLUOROMETHYLORNITHINE HYDROCHLORIDE HYDRATE
  • Ornithine, 2-(difluoromethyl)-
  • Eflornithine base （racemic)
  • DL-EFLORNITHINE
  • EflornithineQ: What is Eflornithine Q: What is the CAS Number of Eflornithine Q: What is the storage condition of Eflornithine Q: What are the applications of Eflornithine
  • α-difluoromethylornithine
  • MFCD00221766 Eflornithine
  • 70052-12-9
  • C6H12N2O2F2
  • Angiogenesis Inhibitors
  • Angiogenesis
  • BioChemical
  • Cancer Research
  • facial hair remover