DFMO

ChemicalBook > CAS DataBase List > DFMO

Product Name: DFMO
CAS No.: 70052-12-9
Chemical Name: DFMO
Synonyms: DIFLUOROMETHYLORNITHINE;DFMO;RFI 71782;Ccris 3295;Brn 2250529;EFLORNITINE;DL-EFLORNITHINE;H-DL-(F2ME)ORN-OH;α-Difluoromethylornitine;α-difluoromethylornithine
CBNumber: CB8373227
Molecular Formula: C6H12F2N2O2
Formula Weight: 182.17
MOL File: 70052-12-9.mol

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DFMO Property

Melting point:: 138 °C
Boiling point:: 347.0±42.0 °C(Predicted)
Density: 1.1800 (estimate)
storage temp.: Store at 0°C
solubility: H₂O: >10 mg/mL, soluble
form: solid
pka: 1.22±0.44(Predicted)
color: white

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Safety

WGK Germany: 3
Hazardous Substances Data: 70052-12-9(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D193
Product name: DL-α-Difluoromethylornithine hydrochloride hydrate
Purity: solid, ≥97% (NMR)
Packaging: 25mg
Price: $241
Updated: 2024/03/01

Sigma-Aldrich

Product number: D193
Product name: DL-α-Difluoromethylornithine hydrochloride hydrate
Purity: solid, ≥97% (NMR)
Packaging: 100mg
Price: $724
Updated: 2024/03/01

Tocris

Product number: 2761
Product name: DFMO
Packaging: 50
Price: $324
Updated: 2021/12/16

Tocris

Product number: 2761
Product name: DFMO
Packaging: 10
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 255132
Product name: DFMO
Packaging: 10mg
Price: $310
Updated: 2021/12/16

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DFMO Chemical Properties,Usage,Production

Chemical Properties

Off-white powder

Uses

DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.

Definition

ChEBI: Eflornithine is a fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. It has a role as a trypanocidal drug. It is a fluoroamino acid and an alpha-amino acid. It is functionally related to an ornithine.

General Description

Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues.

Biological Activity

Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity.

Biochem/physiol Actions

Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.

DFMO Preparation Products And Raw materials

Raw materials

Preparation Products

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DFMO Suppliers

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70052-12-9, DFMORelated Search:

3-Hydroxyphenyl acetate racephedrine Acetonitrile DFMO DFMO-PCV protocol DFMO EFLORNITHINE (S)-2-AMINO-2-METHYLBUTYRIC ACID BETA-FLUORO-DL-ALANINE 2,5-DIAMINO-2-METHYL-PENTANOIC ACID HCL DFMO DFMO,DFMO HCL,DFMO HYDROCHLORIDE DFMO 2-FLUORO-1,1-DIMETHYL-ETHYLAMINE HCL-SALT

96020-91-6 (Mono-hydrochloride, monohydrate)

alpha,delta-Diamino-alpha-(difluoromethyl)valeric acid

Brn 2250529

Ccris 3295

DL-2-(Difluoromethyl)-ornithinehydrochloride

DL-α-Difluoromethylornithine hydrochloride hydrate,2-(Difluoromethyl)ornithine hydrochloride hydrate, DFMO hydrochloride hydrate, Eflornithine hydrochloride hydrate

DIFLUOROMETHYLORNITHINE(RG)

α-Difluoromethyl-DL-ornithine

DFMO hydrochloride hydrate

DL-α-Difluoromethylornithine hydrochloride hydrate

RFI 71782

DL-2-(DIFLUORO-METHYL)-ORNITHINE HCL

DL-(α-difluoromethyl)Orn-OH

α-Difluoromethyl-DL-ornithine≥ 98% (NMR)

2-(difluoromethyl)-ornithin

alpha-difluoromethylornithine

alpha-difluromethylornithine

ALPHA-DIFLUORO-ME-DL-ORNITHINE

ALPHA-DIFLUOROMETHYL-DL-ORNITHINE

2-(Difluoromethyl)ornithine hydrate hydrochloride, DFMO hydrate hydrochloride

DL-α-Difluoromethylornithine hydrate hydrochloride

2-(Difluoromethyl)-2,5-diaminovaleric acid

α-Difluoromethylornitine

DL-α-Difluoromethylornithine hydrochloride

H-DL-(ALPHA-DIFLUOROMETHYL)ORN-OH

H-DL-(F2ME)ORN-OH

H-ALPHA-DIFLUORO-ME-DL-ORN-OH

EFLORNITINE

DL-ALPHA-DIFLUOROMETHYLORNITHINE

DFMO

DIFLUOROMETHYLORNITHINE

DL-ALPHA-DIFLUOROMETHYLORNITHINE HYDROCHLORIDE HYDRATE

Ornithine, 2-(difluoromethyl)-

Eflornithine base （racemic)

DL-EFLORNITHINE

EflornithineQ: What is Eflornithine Q: What is the CAS Number of Eflornithine Q: What is the storage condition of Eflornithine Q: What are the applications of Eflornithine

α-difluoromethylornithine

MFCD00221766 Eflornithine

RMI71782|||DFMO|||α-difluoromethylornithine|||MDL71782

70052-12-9

C6H12N2O2F2

Angiogenesis Inhibitors

Angiogenesis

BioChemical

Cancer Research

facial hair remover