DFMO
- Product Name
- DFMO
- CAS No.
- 70052-12-9
- Chemical Name
- DFMO
- Synonyms
- DIFLUOROMETHYLORNITHINE;DFMO;RFI 71782;Ccris 3295;Brn 2250529;EFLORNITINE;DL-EFLORNITHINE;H-DL-(F2ME)ORN-OH;α-Difluoromethylornitine;α-difluoromethylornithine
- CBNumber
- CB8373227
- Molecular Formula
- C6H12F2N2O2
- Formula Weight
- 182.17
- MOL File
- 70052-12-9.mol
DFMO Property
- Melting point:
- 138 °C
- Boiling point:
- 347.0±42.0 °C(Predicted)
- Density
- 1.1800 (estimate)
- storage temp.
- Store at 0°C
- solubility
- H2O: >10 mg/mL, soluble
- form
- solid
- pka
- 1.22±0.44(Predicted)
- color
- white
Safety
- WGK Germany
- 3
- Hazardous Substances Data
- 70052-12-9(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- D193
- Product name
- DL-α-Difluoromethylornithine hydrochloride hydrate
- Purity
- solid, ≥97% (NMR)
- Packaging
- 25mg
- Price
- $241
- Updated
- 2024/03/01
- Product number
- D193
- Product name
- DL-α-Difluoromethylornithine hydrochloride hydrate
- Purity
- solid, ≥97% (NMR)
- Packaging
- 100mg
- Price
- $724
- Updated
- 2024/03/01
- Product number
- 2761
- Product name
- DFMO
- Packaging
- 50
- Price
- $324
- Updated
- 2021/12/16
- Product number
- 2761
- Product name
- DFMO
- Packaging
- 10
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 255132
- Product name
- DFMO
- Packaging
- 10mg
- Price
- $310
- Updated
- 2021/12/16
DFMO Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Uses
DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.
Definition
ChEBI: Eflornithine is a fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. It has a role as a trypanocidal drug. It is a fluoroamino acid and an alpha-amino acid. It is functionally related to an ornithine.
General Description
Difluoromethylornithine is a?fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic?effects on mammalian cells and tissues.
Biological Activity
Inhibitor of ornithine decarboxylase that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity.
Biochem/physiol Actions
Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.