5-Amino-3-methyl-1-phenylpyrazole

Uses

Product Name: 5-Amino-3-methyl-1-phenylpyrazole
CAS No.: 1131-18-6
Chemical Name: 5-Amino-3-methyl-1-phenylpyrazole
Synonyms: -1-phenyL;AKOS B023009;5-Amino-3-methyL;BUTTPARK 30\03-90;TIMTEC-BB SBB003817;ART-CHEM-BB B023009;5-Amino-3-methyl-1-p;5-AMINO-3-METHYL-PHENYLPYRAZOLE;1-PHENYL-3-METHYL-5-AMINOPYRAZOL;5-methyl-2-phenyl-3-pyrazolamine
CBNumber: CB8376798
Molecular Formula: C10H11N3
Formula Weight: 173.21
MOL File: 1131-18-6.mol

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5-Amino-3-methyl-1-phenylpyrazole Property

Melting point:: 114-117 °C (lit.)
Boiling point:: 333 °C
Density: 1.2894 (rough estimate)
vapor pressure: 0.006Pa at 25℃
refractive index: 1.6250 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3.88±0.10(Predicted)
form: Solid
color: Yellow to pale brown
Water Solubility: 6.051g/L at 25℃
InChI: InChI=1S/C10H11N3/c1-8-7-10(11)13(12-8)9-5-3-2-4-6-9/h2-7H,11H2,1H3
InChIKey: FMKMKBLHMONXJM-UHFFFAOYSA-N
SMILES: N1(C2=CC=CC=C2)C(N)=CC(C)=N1
LogP: 1.76
CAS DataBase Reference: 1131-18-6(CAS DataBase Reference)
NIST Chemistry Reference: 1H-Pyrazol-5-amine, 3-methyl-1-phenyl-(1131-18-6)
EPA Substance Registry System: 1H-Pyrazol-5-amine, 3-methyl-1-phenyl- (1131-18-6)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36
WGK Germany: 3
RTECS: UQ4990000
Hazard Note: Harmful
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29331990
Toxicity: mouse,LD50,oral,1300mg/kg (1300mg/kg),BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS",Personal Communication from LONZA Ltd., CH-4002, Basel, SwitzerlandVol. 03FEB1981,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 541001
Product name: 5-Amino-3-methyl-1-phenylpyrazole
Purity: 97%
Packaging: 5g
Price: $36.54
Updated: 2025/07/31

Sigma-Aldrich

Product number: 541001
Product name: 5-Amino-3-methyl-1-phenylpyrazole
Purity: 97%
Packaging: 25g
Price: $95.2
Updated: 2025/07/31

TCI Chemical

Product number: A1311
Product name: 5-Amino-3-methyl-1-phenylpyrazole
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $48
Updated: 2025/07/31

TRC

Product number: B400020
Product name: 3-Methyl-1-phenyl-1H-pyrazol-5-amine
Packaging: 10g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-7B
Product name: 3-Methyl-1-phenyl-1H-pyrazol-5-amine
Packaging: 100g
Price: $80
Updated: 2021/12/16

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5-Amino-3-methyl-1-phenylpyrazole Chemical Properties,Usage,Production

Uses

3-methyl-1-phenyl-1H-pyrazol-5-amine is a useful research chemical.

Chemical Properties

Yellow crystalline powder

Uses

5-Amino-3-methyl-1-phenylpyrazole may be used to synthesize:

substituted pyrazoles
pyrazolopyridine derivatives
pyrazolo[3,4,-b]pyridines

General Description

5-Amino-3-methyl-1-phenylpyrazole is an aminopyrazole derivative. It reacts with 6-methyl-4-oxo-4H-[1]-benzopyran-3-carboxaldehyde to yield 5-(2-hydroxy-5-methylbenzoyl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine and 2-methoxy-6-methyl-3-(3-methyl-1-phenylpyrazol-5-ylaminomethylene)chroman-4-one.

Flammability and Explosibility

Not classified

Synthesis

1118-61-2

100-63-0

1131-18-6

In a 2-5 mL microwave reaction tube equipped with a stirrer, 3-aminobut-2-enenenitrile (164 mg, 2 mmol) was mixed with 5 mL of 1 M hydrochloric acid solution and stirred until completely dissolved to make a 0.4 M solution of the feedstock. Subsequently, phenylhydrazine (216 mg, 2 mmol) was added to this solution. The reaction tube was sealed with an aluminum cap and placed in a microwave reactor and irradiated at 150 °C for 10 min at a 'very high' absorbance setting. After completion of the reaction, it was cooled to room temperature to obtain a non-homogeneous solution containing an orange precipitate. The pH was adjusted to alkaline with 10% sodium hydroxide solution and sonicated for 5 min to promote solid precipitate formation. The precipitate was collected by filtration, washed twice with deionized water and dried to obtain a light orange solid product (292 mg, 84% yield). For products that do not precipitate easily, the basic aqueous layer can be extracted three times with dichloromethane (DCM) to separate the product. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the target compound.

References

[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 42, p. 7806 - 7810
[2] Tetrahedron Letters, 2019, vol. 60, # 1, p. 72 - 74
[3] Chemistry of Heterocyclic Compounds, 2018, vol. 54, # 1, p. 51 - 57
[4] Khim. Geterotsikl. Soedin., 2018, vol. 54, # 1, p. 51 - 57,7
[5] Journal of Organic Chemistry, 1993, vol. 58, # 22, p. 6155 - 6157

5-Amino-3-methyl-1-phenylpyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

Acid Yellow 49

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5-Amino-3-methyl-1-phenylpyrazole Suppliers

Americas 1 Belgium 1 Canada 1 China 147 Czech Republic 1 Europe 1 France 2 Germany 9 India 31 Japan 3 Russia 3 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 16 United States 46 Global 265

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View Lastest Price from 5-Amino-3-methyl-1-phenylpyrazole manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Amino-3-methyl-1-phenylpyrazole 1131-18-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 5000KG
Release date: 2024-07-18

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Amino-3-methyl-1-phenylpyrazole 1131-18-6
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-07-14

Career Henan Chemical Co

Product: 5-Amino-3-methyl-1-phenylpyrazole 1131-18-6
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

1131-18-6, 5-Amino-3-methyl-1-phenylpyrazoleRelated Search:

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1131-18-6

1131-18-9

Pyrazoles

Building Blocks

Heterocyclic Building Blocks

Pyrazoles

Heterocyclic Compounds

Intermediates of Dyes and Pigments

Pyrazole series