1,4-DIOXA-SPIRO[4.5]DECAN-8-OL

Product Name: 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL
CAS No.: 22428-87-1
Chemical Name: 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL
Synonyms: 4-Dioxaspiro[4.5]decan-8-ol;4,4-Ethylenedioxycyclohexanol.;1,4-DIOXA-SPIRO[4.5]DECAN-8-OL;4,4-(Ethylenebisoxy)cyclohexanol;1,4-Dioxaspiro[4.5]decan-8-ol,98%;4-Hydroxycyclohexanone ethylene acetal;4-HYDROXYCYCLOHEXANONE MONOETHYLENE KETAL;4-Hydroxycyclohexanone ethylene acetal, 90+%;4-Hydroxycyclohexanone ethylene glycol ketal;4-Hydroxycyclohexan-1-one monoethylene ketal
CBNumber: CB8379557
Molecular Formula: C8H14O3
Formula Weight: 158.2
MOL File: 22428-87-1.mol

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1,4-DIOXA-SPIRO[4.5]DECAN-8-OL Property

Boiling point:: 103-104 °C(Press: 0.55 Torr)
Density: 1.17±0.1 g/cm3(Predicted)
refractive index: 1.485-1.487
storage temp.: Inert atmosphere,2-8°C
pka: 15.11±0.20(Predicted)
form: Viscous Liquid
color: Clear colorless
InChI: InChI=1S/C8H14O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h7,9H,1-6H2
InChIKey: HKQTYQDNCKMNHZ-UHFFFAOYSA-N
SMILES: O1C2(CCC(O)CC2)OCC1

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D6215
Product name: 1,4-Dioxaspiro[4.5]decan-8-ol
Purity: min. 98.0 %
Packaging: 5G
Price: $70
Updated: 2025/07/31

TCI Chemical

Product number: D6215
Product name: 1,4-Dioxaspiro[4.5]decan-8-ol
Purity: min. 98.0 %
Packaging: 25G
Price: $210
Updated: 2025/07/31

TRC

Product number: D486285
Product name: 1,4-Dioxaspiro[4.5]decan-8-ol
Packaging: 1g
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 020028
Product name: 4-Hydroxycyclohexanone monoethylene ketal
Packaging: 1g
Price: $10
Updated: 2021/12/16

AK Scientific

Product number: W4619
Product name: 1,4-Dioxaspiro[4.5]decan-8-ol
Packaging: 1g
Price: $14
Updated: 2021/12/16

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1,4-DIOXA-SPIRO[4.5]DECAN-8-OL Chemical Properties,Usage,Production

Chemical Properties

clear colorless viscous liquid

Uses

1,4-Dioxaspiro[4.5]decan-8-ol can be used to synthesize pharmaceutical compounds such as diuretics.

Synthesis

4746-97-8

22428-87-1

Step A: Preparation of 4-dioxaspiro[4.5]decan-8-ol 1,4-Cyclohexanedione monoethylene glycol ketal (5.0134 g, 32.10 mmol) was dissolved in methanol (100 mL) and cooled in an ice bath. Sodium borohydride (3.64 g, 96.30 mmol) was added to the solution in batches over 20 min. The reaction mixture was stirred at 0 °C for 30 min, then slowly warmed to room temperature and continued stirring for 1 h. The reaction mixture was then stirred at 0 °C for 1 h. The reaction mixture was then stirred at 0 °C for 1 h. Upon completion of the reaction, 4-hydroxycyclohexanone ethylene glycol acetal (5.56 g, 109% yield) was obtained by a standard post-processing step, the product was a yellow oil and could be used in subsequent reactions without further purification. The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-D): δ 1.47-1.70 (m, 5H), 1.72-1.92 (m, 4H), 3.70-3.83 (m, 1H), 3.85-3.96 (m, 4H).

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 12, p. 2243 - 2247
[2] Journal of the American Chemical Society,
[3] Journal of the American Chemical Society, 2009, vol. 131, p. 251 - 262
[4] Patent: US2009/275574, 2009, A1. Location in patent: Page/Page column 16
[5] Patent: WO2013/30665, 2013, A1. Location in patent: Page/Page column 175; 176

1,4-DIOXA-SPIRO[4.5]DECAN-8-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-DIOXA-SPIRO[4.5]DECAN-8-OL Suppliers

Belgium 2 China 178 China Hong Kong 1 Germany 2 India 3 Japan 1 Switzerland 1 Ukraine 1 United Kingdom 3 United States 19 Global 211

Accela ChemBio Inc.

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View Lastest Price from 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL 22428-87-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.50%
Supply Ability: 20tons
Release date: 2023-09-14

Career Henan Chemical Co

Product: 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL 22428-87-1
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-08

22428-87-1, 1,4-DIOXA-SPIRO[4.5]DECAN-8-OLRelated Search:

Cyclohexanone 4-HYDROXYCYCLOHEXANONE 8-(4-CHLORO-PHENYL)-1,4-DIOXA-SPIRO[4.5]DECAN-8-OL 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL 8-(4-BROMOPHENYL)-1,4-DIOXASPRIO[4,5]DECAN-8-OL 4-(8-HYDROXY-1,4-DIOXA-SPIRO[4.5]DEC-8-YL)-BENZONITRILE 1,4-DIOXASPIRO[4.5]DECAN-8-YL METHANESULFONATE N-(4-CHLOROPHENYL)-1,4,9-TRIOXA-12-AZADISPIRO[4.2.4.2]TETRADECANE-12-CARBOXAMIDE 8-PHENYL-1,4-DIOXASPIRO[4,5]DECAN-8-OL CHEMPACIFIC 43811 8-(3-HYDROXY-PROPYL)-1,4-DIOXA-SPIRO[4.5]DECAN-8-OL ACETIC ACID 1,4-DIOXA-SPIRO[4.5]DEC-8-YL ESTER 3-(8-HYDROXY-1,4-DIOXA-SPIRO[4,5]DEC-8-YL)-BENZONITRILE AKOS 90421 1,4-Cyclohexanedione bis(ethylene ketal)

4-HYDROXYCYCLOHEXANONE MONOETHYLENE KETAL

1,4-DIOXA-SPIRO[4.5]DECAN-8-OL

4,4-Ethylenedioxycyclohexanol.

4-Hydroxycyclohexanone ethylene acetal, 90+%

4,4-(Ethylenebisoxy)cyclohexanol

1,4-Dioxaspiro[4.5]decan-8-ol,98%

4-Dioxaspiro[4.5]decan-8-ol

4-Hydroxycyclohexanone ethylene acetal

4-Hydroxycyclohexan-1-one monoethylene ketal 98%

1,4-Dioxaspiro[4.5]decan-8-ol (6CI, 8CI, 9CI, ACI)

4-hydroxycyclohexanone ethylene glycol acetal

4-Hydroxycyclohexanone ethylene glycol ketal

4-Hydroxycyclohexan-1-one monoethylene ketal

22428-87-1

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