ChemicalBook > CAS DataBase List > 1-(2-Hydroxyethyl)imidazole

1-(2-Hydroxyethyl)imidazole

Product Name
1-(2-Hydroxyethyl)imidazole
CAS No.
1615-14-1
Chemical Name
1-(2-Hydroxyethyl)imidazole
Synonyms
1H-imidazole-1-ethanol;2-(1-IMIDAZOLYL)ETHANOL;2-iMidazol-1-yl-ethanol;1-HYDROXYETHYL IMIDAZOLE;1-(2-HYDROXYETHYL)IMIDAZOLE;2-(1H-IMidazol-1-yl)ethanol;N-(2-HYDROXYETHYL)-IMIDAZOLE;1-(2-Hydroxyethyl)imidazole,95%;1-(2-Hydroxyethyl)-1H-imidazole;1-(2-Hydroxyethyl)iMidazole 97%
CBNumber
CB8381554
Molecular Formula
C5H8N2O
Formula Weight
112.13
MOL File
1615-14-1.mol
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1-(2-Hydroxyethyl)imidazole Property

Melting point:
36-40 °C (lit.)
Boiling point:
115 °C
Density 
1.1524 (rough estimate)
refractive index 
1.518-1.52
Flash point:
110 °C
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
13.82±0.10(Predicted)
Appearance
White to light yellow <36°C Solid,>40°C Liquid
InChI
InChI=1S/C5H8N2O/c8-4-3-7-2-1-6-5-7/h1-2,5,8H,3-4H2
InChIKey
AMSDWLOANMAILF-UHFFFAOYSA-N
SMILES
C1N(CCO)C=CN=1
CAS DataBase Reference
1615-14-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
576166
Product name
1-(2-Hydroxyethyl)imidazole
Purity
97%
Packaging
5g
Price
$67.5
Updated
2025/07/31
TCI Chemical
Product number
I1193
Product name
2-(1H-Imidazol-1-yl)ethanol
Purity
min. 98.0 %
Packaging
5G
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
I1193
Product name
2-(1H-Imidazol-1-yl)ethanol
Purity
min. 98.0 %
Packaging
25G
Price
$123
Updated
2025/07/31
TRC
Product number
H998220
Product name
1-(2-Hydroxyethyl)imidazole
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
J94614
Product name
2-(1H-Imidazol-1-yl)ethanol
Packaging
5g
Price
$25
Updated
2021/12/16
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1-(2-Hydroxyethyl)imidazole Chemical Properties,Usage,Production

Chemical Properties

yellow viscous liquid

Synthesis

17450-34-9

1615-14-1

A solution of anhydrous THF (20 mL) of ethyl 2-(1-imidazolyl)acetate (6.05 g, 39.2 mmol) was added dropwise to a mixture of lithium aluminum hydride (3.00 g, 79.1 mmol) and anhydrous THF (60 mL) at 0 °C under a dry argon atmosphere. The reaction mixture was stirred at 0 °C for 5 minutes, followed by continued stirring at room temperature for 4 hours. Upon completion of the reaction, water (3 mL), 15% aqueous sodium hydroxide solution (3 mL) and water (9 mL) were added sequentially and dropwise at 0 °C to quench the reaction. The resulting mixture was stirred at room temperature for 12 hours and then filtered. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography using chloroform/methanol (10:1, v/v) as eluent. The grades with an Rf value of 0.22 were collected and further purified twice by decompression distillation to finally obtain 1-(2-hydroxyethyl)imidazole (Im2OH) as a colorless oil (2.386 g, 54% yield).

References

[1] Medicinal Chemistry, 2012, vol. 8, # 5, p. 865 - 873
[2] Journal of Medicinal Chemistry, 1996, vol. 39, # 10, p. 1991 - 2007
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 6, p. 2604 - 2610
[4] Reactive and Functional Polymers, 2016, vol. 99, p. 1 - 8
[5] European Journal of Medicinal Chemistry, 2009, vol. 44, # 8, p. 3350 - 3355

1-(2-Hydroxyethyl)imidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(2-Hydroxyethyl)imidazole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(2-Hydroxyethyl)imidazole 1615-14-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
1-(2-Hydroxyethyl)imidazole 1615-14-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons/month
Release date
2020-01-08

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