Adenosine 5'-monophosphate monohydrate
Pharmacodynamics- Product Name
- Adenosine 5'-monophosphate monohydrate
- CAS No.
- 18422-05-4
- Chemical Name
- Adenosine 5'-monophosphate monohydrate
- Synonyms
- A-5'-P;5'-AMP;AMP.H2O;5'-AMPH2;5'-AMP H2O;AMP monohydrate;5'-AMP MONOHYDRATE;5'-AMP=Adenylicacid;Adenosine-5’-phospho;Bucladesine Impurity 4
- CBNumber
- CB9343816
- Molecular Formula
- C10H16N5O8P
- Formula Weight
- 365.24
- MOL File
- 18422-05-4.mol
Adenosine 5'-monophosphate monohydrate Property
- Melting point:
- 183-188 °C (dec.)(lit.)
- alpha
- -48 º (c=2% in 2% NaOH)
- FEMA
- 4224 | ADENOSINE MONOPHOSPHATE; MONOSODIUM, OR DISODIUM ADENYLATE
- storage temp.
- -20°C
- solubility
- H2O: with addition of mild alkalisoluble
- form
- Solid
- color
- White to Off-White
- Merck
- 14,158
- BRN
- 5205540
- CAS DataBase Reference
- 18422-05-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A2252
- Product name
- Adenosine 5′-monophosphate monohydrate
- Purity
- from yeast, ≥97%
- Packaging
- 5g
- Price
- $62.8
- Updated
- 2024/03/01
- Product number
- A2252
- Product name
- Adenosine 5′-monophosphate monohydrate
- Purity
- from yeast, ≥97%
- Packaging
- 25g
- Price
- $228
- Updated
- 2024/03/01
- Product number
- A2252
- Product name
- Adenosine 5′-monophosphate monohydrate
- Purity
- from yeast, ≥97%
- Packaging
- 100g
- Price
- $637
- Updated
- 2024/03/01
- Product number
- A281830
- Product name
- Adenosine 5′-monophosphate monohydrate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-8159
- Product name
- Adenosine 5′-monophosphate monohydrate
- Purity
- 99.07%
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
Adenosine 5'-monophosphate monohydrate Chemical Properties,Usage,Production
Pharmacodynamics
Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. AMP is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet.
Chemical Properties
White crystalline powder
Uses
Nutrient;Ca++ channel block
Uses
Adenosine 5′-monophosphate (5′AMP) is suitable for use as
- a reagent in the synthesis of adenosine-5′-phosphoimidazolide
- an activator of phosphorylase b in the polymerization reaction for the synthesis of branched polysaccharides
- an inhibitor of endogenous NMN adenylyltransferase (NMNAT) activity that converts NMN to NAD+
Definition
ChEBI: Adenosine 5'-monophosphate monohydrate is a purine ribonucleoside monophosphate.
Biochem/physiol Actions
Adenosine 5′-monophosphate (5′-AMP) has many uses in nature. 5′-AMP is an activator of a class of protein kinases known as AMP-activated protein kinase (AMPK). AMP inhibits dephosphorylation of AMPK and promotes phosphorylation of AMPK by upstream kinases.
Purification Methods
The acid has been recrystallised from H2O (fine needles) and is freely soluble in boiling H2O. It crystallises also from H2O on addition of acetone. Alternatively purify it by chromatography on Dowex 1 (in formate form), eluting with 0.25M formic acid. It is then adsorbed onto charcoal (which had been boiled for 15minutes with M HCl, washed free of chloride and dried at 100o) and recovered by stirring three times with isoamyl alcohol/H2O (1:9 v/v). The aqueous layer from the combined extracts is evaporated to dryness under reduced pressure, and the product is crystallised twice from hot H2O. [Morrison & Doherty Biochem J 79 433 1961]. It has max 259nm ( 15,400) in H2O at pH 7.0. [Alberty et al. J Biol Chem 193 425 1951, Martell & Schwarzenbach Helv Chim Acta 39 653 1956]. The acridinium salt has m 208o [Baddiley & Todd J Chem Soc 648 1947, Pettit Synthetic Nucleotides, van Nostrand-Reinhold, NY, Vol 1 252 1972, NMR: Sarma et al. J Am Chem Soc 96 7337 1974, Norton et al. J Am Chem Soc 98 1007 1976, IR of diNa salt: Miles Biochem Biophys Acta 27 324 1958]. [Beilstein 26 III/IV 3615.]
Adenosine 5'-monophosphate monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Adenosine 5'-monophosphate monohydrate manufacturers
- Product
- Adenosine 5'-monophosphate monohydrate 18422-05-4
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kgs
- Release date
- 2021-09-08
- Product
- Adenosine 5'-monophosphate monohydrate 18422-05-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29
- Product
- Adenosine 5'-monophosphate monohydrate 18422-05-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99.99%
- Supply Ability
- 1kg-10MT
- Release date
- 2019-05-24