TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE

Product Name: TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
CAS No.: 77279-24-4
Chemical Name: TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
Synonyms: BUTTPARK 46\04-31;Boc-Piperazine-OH;BOC-N-(2-HYDROXYETHYL)PIPERAZINE;1-Boc-4-(2-hydroxyethyl)-piperazi;1-BOC-4-(2-HYDROXYETHYL)-PIPERAZINE;N-Boc-N’-(2-hydroxyethyl)-piperazine;1-Boc-4-(2-hydroxyethyl)piperazine 97%;N-BOC-Nzzhlxy-(2-hydroxyethyl)piperazine;tert-Butyl 4-(2-hydroxyethyl)piperazine-1-;4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE
CBNumber: CB8389646
Molecular Formula: C11H22N2O3
Formula Weight: 230.3
MOL File: 77279-24-4.mol

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TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE Property

Melting point:: 38-42 °C
Boiling point:: 114°C 0,1mm
Density: 1.092±0.06 g/cm3(Predicted)
Flash point:: 110 °C
storage temp.: 2-8°C
pka: 14.96±0.10(Predicted)
form: Solid
color: White to pale brown
InChI: InChI=1S/C11H22N2O3/c1-11(2,3)16-10(15)13-6-4-12(5-7-13)8-9-14/h14H,4-9H2,1-3H3
InChIKey: VRXIOAYUQIITBU-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(CCO)CC1
CAS DataBase Reference: 77279-24-4(CAS DataBase Reference)

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Safety

Hazard Codes: C,N,T
Risk Statements: 36/37/38-50-25
Safety Statements: 26-36/37/39-61-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 685909
Product name: 1-Boc-4-(2-hydroxyethyl)piperazine
Purity: 97%
Packaging: 5g
Price: $130
Updated: 2023/06/20

TCI Chemical

Product number: B6368
Product name: tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate
Purity: min. 98.0 %
Packaging: 5G
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: B6368
Product name: tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate
Purity: min. 98.0 %
Packaging: 25G
Price: $122
Updated: 2025/07/31

TRC

Product number: B943578
Product name: tert-Butyl4-(2-hydroxyethyl)piperazine-1-carboxylate
Packaging: 5g
Price: $130
Updated: 2021/12/16

TRC

Product number: B943578
Product name: tert-Butyl4-(2-hydroxyethyl)piperazine-1-carboxylate
Packaging: 1g
Price: $45
Updated: 2021/12/16

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TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Boc-Piperazine-OH is a PROTAC Linker in SJ46420 (HY-168635)[1].

Synthesis

103-76-4

24424-99-5

77279-24-4

General procedure: synthesis of tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (57): 1-(2-hydroxyethyl)piperazine (3.0 g, 23.0 mmol) was dissolved in dry tetrahydrofuran (THF) under nitrogen protection. Subsequently, di-tert-butyl dicarbonate (5.5 g, 25.3 mmol) was slowly added to this solution. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the solvent was evaporated to half of the initial volume by rotary evaporator. The concentrated mixture was poured into deionized water and extracted with dichloromethane (CH2Cl2). The organic phases were combined, washed with saturated saline and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated under reduced pressure to afford the light yellow oily product tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (5.3 g, quantitative yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 1.46 (s, 9H), 2.44-2.46 (m, 4H), 2.54-2.57 (m, 2H), 2.66 (m, J = 5.3 Hz, 1H), 3.42-3.45 (m, 4H), 3.62 (q, J = 5.3 Hz, 2H).

References

[1] Scott DC, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. DOI:10.1038/s41467-024-52966-3

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Preparation Products

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View Lastest Price from TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE 77279-24-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-03

77279-24-4, TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATERelated Search:

Methyltetrazine-Amine BREDERECK'S REAGENT TERT-BUTYL VINYL ETHER tert-Butyldimethylsilyl chloride 4-Boc-1-piperazineacetic acid 2-(4-Boc-Piperazinyl)-2-phenylacetic acid 2-(4-BOC-PIPERAZINYL)-4-PHENYLBUTANOIC ACID 2-(4-BOC-PIPERAZINYL)-2-(4-METHYLPHENYL)ACETIC ACID 2-(THIOPHEN-2-YL)-3-(4-BOC-PIPERAZIN-1-YL)ACETIC ACID TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE 2-(1-TERT-BUTOXYCARBONYLPIPERAZIN-4-YL)PROPIONIC ACID 4-[CARBOXY-(4-METHOXY-PHENYL)-METHYL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE 2-(4-BOC-PIPERAZINYL)-2-(3-PYRIDINYL)ACETIC ACID 1-BOC-4-[CARBOXY-(1H-INDOL-2-YL)-METHYL]-PIPERAZINE 2-(4-BOC-PIPERAZINYL)-2-(2-METHOXY-PHENYL)ACETIC ACID (3E)-2-(4-BOC-PIPERAZINYL)-4-PHENYL-3-BUTENOIC ACID (+/-)-1-AMINO-3-N-(4'-BOC-PIPERAZINYL)-2-PROPANOL 4-[CARBOXY-(4-TRIFLUOROMETHYL-PHENYL)-METHYL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

TERT-BUTYL 4-(2-HYDROXYETHYL)TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE

BUTTPARK 46\04-31

BOC-N-(2-HYDROXYETHYL)PIPERAZINE

[4-(2-hydroxyethyl)-1-[(2-methylpropan-2-yl)oxy]-2-piperazinylidene]methanone

4-(2-HYDROXYETHYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(2-HYDROXYETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

1-BOC-4-(2-HYDROXYETHYL)-PIPERAZINE

1-(TERT-BUTOXYCARBONYL)-4-(2-HYDROXYETHYL)PIPERAZINE

1-TERT-BUTYLOXY CARBONYL-4-HYDROXYETHYL PIPERAZINE

N-Boc-N’-(2-hydroxyethyl)-piperazine

4-(2-Hydroxyethyl)piperazine, N1-BOC protected

tert-Butyl 4-(2-hydroxyethyl)piperazine-1-

4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE

1-Boc-4-(2-hydroxyethyl)piperazine 97%

1,1-Dimethylethyl 4-(2-hydroxyethyl)piperazine-1-carboxylate

N-BOC-Nzzhlxy-(2-hydroxyethyl)piperazine

1-Piperazinecarboxylic acid, 4-(2-hydroxyethyl)-, 1,1-dimethylethyl ester

1-Boc-4-(2-hydroxyethyl)-piperazi

Boc-Piperazine-OH

77279-24-4

pharmacetical

Hydroxymethyl's

Pyrans, Piperidines &Piperazines

Piperaizine

Pyrans, Piperidines & Piperazines

Building Blocks

Heterocyclic Building Blocks

Piperazines