Dexchlorpheniramine Maleate

Product Name: Dexchlorpheniramine Maleate
CAS No.: 2438-32-6
Chemical Name: Dexchlorpheniramine Maleate
Synonyms: Polamin;Phenamin;Sensidyn;polaramin;Polaramine;d-Form maleate;poraminemaleate;polaraminemaleate;Dexclobenamine maleate;D-CHLORPHENIRAMINE MALEATE
CBNumber: CB8392741
Molecular Formula: C20H23ClN2O4
Formula Weight: 390.86
MOL File: 2438-32-6.mol

More

Less

Dexchlorpheniramine Maleate Property

Melting point:: 112-115 °C(lit.)
alpha: D25 +44.3° (c = 1 in dimethylformamide)
storage temp.: 2-8°C
solubility: Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
form: Solid
color: White to off-white
PH: pH(10g/l, 25℃) : 4.0～5.0
Merck: 13,2198

More

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: US6504000
HS Code: 2933399090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2803
Product name: Dexchlorpheniramine Maleate
Packaging: 500MG
Price: $173
Updated: 2024/03/01

Sigma-Aldrich

Product number: C4915
Product name: S-(+)-Chlorpheniramine maleate salt
Packaging: 1g
Price: $102
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1179005
Product name: Dexchlorpheniramine maleate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 300mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 24027
Product name: Dexchlorpheniramine (maleate)
Purity: ≥98%
Packaging: 500mg
Price: $59
Updated: 2024/03/01

Cayman Chemical

Product number: 24027
Product name: Dexchlorpheniramine (maleate)
Purity: ≥98%
Packaging: 1g
Price: $86
Updated: 2024/03/01

More

Less

Dexchlorpheniramine Maleate Chemical Properties,Usage,Production

Description

Dexchlorpheniramine Maleate is the maleate salt form of dexchlorpheniramine, an alkylamine, and first-generation histamine antagonist with anti-allergic activity. Dexchlorpheniramine maleate competitively blocks H1 receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.

Chemical Properties

Dexchlorpheniramine maleate is a white, odourless, crystalline powder which in aqueous solution has a pH of between 4 and 5. It is freely soluble in water, soluble in alcohol and in chloroform, but only slightly soluble in benzene or ether.

Originator

Polaramine,Schering,US,1958

Uses

Dexchlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. Polaramine (dexchlorpheniramine maleate) is the dextro-isomer of chlorpheniramine maleate and the S-enantiomer of Chlorpheniramine. It is an antihistamine with anticholinergic properties. S-(+)-Chlorpheniramine maleate salt has been used to study the anticholinergic effect of Achillea millefolium and Portulaca olerace on muscarinic receptors of guinea pig tracheal smooth muscle.

Definition

ChEBI: Dexchlorpheniramine maleate is an organic molecular entity.

Manufacturing Process

Twenty grams of d-phenylsuccinic acid and 28 grams of 3-(2-pyridyl)-3-pchlorophenyl-N,N-dimethylpropylamine are dissolved in 400 ml of absolute ethyl alcohol and allowed to stand at room temperature until crystallization is effected. The crystals are filtered, washed with absolute ethyl alcohol and recrystallized from 300 ml of this solvent in the same manner. The crystals are recrystallized twice from 80% ethyl alcohol using 3.5 ml per gram of compound in the manner described above and pure d-3-(2-pyridyl)-3-pchlorophenyl-N,Ndimethylpropylamine-d-phenylsuccinate is obtained, melting point 145-147°C.
This salt is shaken with 100 ml of diethyl ether and 50 ml of 20% aqueous potassium carbonate; the ether layer is separated, dried over anhydrous potassium carbonate, filtered and the ether is removed in vacuo. The d-3-(2- pyridyl)-3-p-chlorophenyl-N,N-dimethylpropylamine so obtained is a mobile oil.
4.3 grams of the above base and 1.8 grams of maleic acid are dissolved in 20 ml isopropyl acetate and kept at room temperature until crystallization is complete. The crystals are filtered, washed with ethyl acetate and recrystallized from 15 ml of this solvent in the same manner. The crystalline d-3-(2-pyridyl)-3-p-chlorophenyl-N,N-dimethylpropylamine maleate so formed is then filtered off and dried. MP 113-115°C from US Patent 3,030,371.

brand name

Mylaramine (Morton Grove); Polaramine (Schering).

Therapeutic Function

Antihistaminic

General Description

Dexchlorpheniramine(Polaramine) is the dextrorotatory enantiomer of chlorpheniramine.In vitro and in vivo studies of the enantiomers ofchlorpheniramine showed that the antihistaminic activity existspredominantly in the dextro isomer. As mentioned previously,the dextro isomer has the (S) configuration, which issuperimposable on the (S) configuration of the more activelevorotatory enantiomer of carbinoxamine.

Biochem/physiol Actions

H1 histamine receptor antagonist; active isomer.Chlorpheniramine maleate is clinically used as a topical ointment to treat skin disorders such as sunburn, urticaria, angioedema, pruritus and insect bites.

Mode of action

Dexchlorpheniramine, the d-isomer of the racemic compound chlorpheniramine, is two times more active than chlorpheniramine. Dexchlorpheniramine does not prevent the release of histamine, but rather, competes with free histamine for binding at the H1-receptor sites, and competitively antagonizes the effects of histamine on H1- receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Blockade of H1-receptors also suppresses the formation of oedema, flare, and pruritus that result from histaminic activity. Since dexchlorpheniramine binds to central and peripheral H1-receptors, sedative effects are likely to occur. H1- antagonists are structurally similar to anticholinergic agents and therefore possess the potential to exhibit anticholinergic properties of varying degrees. They also have antipruritic effects. Dexchlorpheniramine has high antihistaminic activity, moderate anticholinergic effects and minimal sedative effects. The medicine does not possess antiemetic properties.

References

[1] P. E. CHAVES. Assessment of cytotoxicity, genotoxicity, and mutagenicity of the dexchlorpheniramine reference standard and pharmaceutical formula in human peripheral blood mononuclear cells[J]. Brazilian Journal of Pharmaceutical Sciences, 2022, 18 1. DOI:10.1590/s2175-97902022e20096.
[2] GUSTAVO FACCHINI MSC. Ultraviolet A photosensitivity profile of dexchlorpheniramine maleate and promethazine-based creams: Anti-inflammatory, antihistaminic, and skin barrier protection properties[J]. Journal of Cosmetic Dermatology, 2017, 16 4: e59-e67. DOI:10.1111/jocd.12349.
[3] MASAAKI TAGAWA. Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine.[J]. British journal of clinical pharmacology, 2001, 52 5 1: 501-509. DOI:10.1046/J.1365-2125.2001.01471.X.
[4] DONG LIANG. Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning[J]. Acta Pharmaceutica Sinica B, 2022, 12 5: Pages 2429-2442. DOI:10.1016/j.apsb.2021.12.005.

Dexchlorpheniramine Maleate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Dexchlorpheniramine Maleate Suppliers

Canada 1 China 65 Europe 2 France 1 Germany 1 India 29 Italy 1 Japan 5 Slovakia 1 Switzerland 2 United Kingdom 6 United States 28 Global 142

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19885
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Aceto Corporation

Tel: --
Fax: --
Email: contact@aceto.com
Country: United States
ProdList: 2619
Advantage: 75

PCI Synthesis, Inc.

Tel: --
Fax: --
Email: sales@pcisynthesis.com
Country: United States
ProdList: 138
Advantage: 51

Advance Scientific & Chemical

Tel: --
Fax: --
Email: sales@advance-scientific.com
Country: United States
ProdList: 6419
Advantage: 71

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

Fine Chem Trading LTD

Tel: --
Fax: --
Email: chemfinder@chemfinder.co.uk
Country: United States
ProdList: 1609
Advantage: 64

ASDI Incorporated

Tel: --
Fax: --
Email: customerservice@asdi.net
Country: United States
ProdList: 6922
Advantage: 67

Parchem Trading Ltd.

Tel: --
Fax: --
Email: info@parchem.com
Country: United States
ProdList: 794
Advantage: 76

Sciencelab.com, Inc.

Tel: --
Fax: --
Email: accounting@sciencelab.com
Country: United States
ProdList: 4159
Advantage: 82

BADRIVISHAL CHEMICALS & PHARMACEUTICALS

Tel: --
Fax: --
Email: info@badrivishal.com
Country: United States
ProdList: 12
Advantage: 38

Cadila Pharmaceuticals Limited

Tel: --
Fax: --
Email: opalinfo@vsnl.net
Country: United States
ProdList: 10
Advantage: 77

Spectrum Chemicals & Laboratory Products

Tel: --
Fax: --
Email: sales@spectrumchemical.com
Country: United States
ProdList: 6699
Advantage: 77

Napp Technologies LLC

Tel: --
Fax: --
Country: United States
ProdList: 81
Advantage: 51

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

Cambridge Isotope Laboratories, Inc.

Tel: --
Fax: --
Email: cilsales@isotope.com
Country: United States
ProdList: 6598
Advantage: 79

More

Less

View Lastest Price from Dexchlorpheniramine Maleate manufacturers

Career Henan Chemical Co

Product: DEXCHLORPHENIRAMINE MALEATE 2438-32-6
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 98%
Supply Ability: 1kg,2kg,100kg
Release date: 2019-07-09

2438-32-6, Dexchlorpheniramine MaleateRelated Search:

2-Phenoxyethanol Ceramides Nicotinic acid Nicotinamide Arbutin Centella asiatica extract Squalane HexanitrodiphenylaMine Dexchlorpheniramine Maleate 2-(4-Chlorobenzyl)pyridine Pheniramine maleate DEXCHLORPHENIRAMINE Ammonium hydrogen maleate Chlorphenamine maleate 3-(4-CHLORO-PHENYL)-PROPYLAMINE 3-(2-PYRIDINYL)PROPYLAMINE BROMPHENIRAMINE MALEATE IMP. B (EP) AS MALEATE: DEXCHLORPHENIRAMINE MALEATE DEXCHLORPHENIRAMINE MALEATE IMP. A (EP) AS MALEATE: (3RS)-N,N-DIMETHYL-3-PHENYL-3-(PYRIDIN-2-YL)PROPAN-1-AMINE MALEATE

(+)-CHLORPHENIRAMINE MALEATE SALT

DEXCHLOROPHENIRAMINE MALEATE

DEXCHLORPHENIRAMINE MALEATE

D-CHLORPHENIRAMINE MALEATE

GAMMA-[4-CHLOROPHENYL]-N,N-DIMETHYL-2-PYRIDINEPROPANAMINE MALEATE SALT

(+)-2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinemaleate

(Z)-but-2-enedioic acid,(3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine

(s)-(+)-chlorpheniraminemaleate

dextrochlorpheniraminemaleate

g-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanaminemaleate

polaramin

polaraminemaleate

poraminemaleate

pyridine,2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-,maleate(1:1),(+

γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine

d-Form maleate

s-(+)-chlorpheniraminemaleate

[gamma-(4-chlorophenyl)-pyridine-2-propyl](dimethyl)ammonium hydrogen (Z)-maleate

DexchlorpheniramineMaleate-Bp/Ep/Usp

2-Pyridinepropanamine, .gamma.-(4-chlorophenyl)-N,N-dimethyl-, (.gamma.S)-, (2Z)-2-butenedioate (1:1)

(s)-γ-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamine maleate salt

s-(+)-chlorpheniramine maleate salt

DEXCHLORPHENIRAMINEMALEATE,USP

2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (S)-, (Z)-2-butenedioate (1:1)

2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (γS)-, (2Z)-2-butenedioate (1:1)

d-2-[p-Chloro-α-(2-dimethylaminoethyl)benzyl]pyridine bimaleate

Dexchlorpheniramine hydrogen maleate

Phenamin

Polamin

Polaramine

Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, maleate (1:1), (S)- (8CI)

Sensidyn

γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine, (+)-Chlorpheniramine maleate salt

Chlorpheniramine d-maleate

d-Chlorpheniramine·maleic acid

(+)-Chloropromazine Maleate

Dexchlorpheniramine Maleate (300 mg)

(γS)-γ-(4-Chlorophenyl)-N,N-diMethyl-2-pyridinepropanaMine (2Z)-2-Butenedioate

2-[p-Chloro-α-[2-(diMethylaMino)ethyl]benzyl]pyridine Maleate

Dexchlorpheniramine maleate CRS

(S)-Chlorpheniramine Maleate(Dexchlorpheniramine Maleate)

DEXCHLORPHENIRAMINE MALEATE USP/EP/BP

Dexchlorpheniramine maleateQ: What is Dexchlorpheniramine maleate Q: What is the CAS Number of Dexchlorpheniramine maleate Q: What is the storage condition of Dexchlorpheniramine maleate

Dexchlorpheniramine Maleate (1179005)

[3-(11,12-Dihydro-6H-dibenzo[b,f]azocin-5-yl)-propyl]-dimethyl-amine

(S)-3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate

Histamine Receptor,Dexchlorpheniramine Maleate,Dexchlorpheniramine,inhibit,Inhibitor

Brompheniramine Maleate Impurity B as Maleate

Brompheniramine Maleate EP Impurity B as Maleate

(+)-Chloropromazine maleate

Dexclobenamine maleate

2438-32-6

C20H23ClN2O4

39086

H1 histamine receptor antagonist; active isomer.

DIDRONEL

Amines

Chiral Reagents