Tocofersolan
- Product Name
- Tocofersolan
- CAS No.
- 9002-96-4
- Chemical Name
- Tocofersolan
- Synonyms
- tpgs;VITAMIN E TPGS;Vitamin E polyethylene glycol succinate;d-alpha-tocopheryl polyethylene glycol succinate;Tocophersolan;D-α-Tocopherol polyethylene glycol succinate;tocopherosolan;D-a-Tocopherol Polyethylene Glycol Succinate;d-alpha-tocopherylpoly(ethyleneglycol)1000succinate;D-a-Tocopherol Polyethylene Glycol Succinate (Vitamin E TPGS)
- CBNumber
- CB8396198
- Molecular Formula
- (C2H4O)nC33H54O5
- Formula Weight
- 0
- MOL File
- 9002-96-4.mol
Tocofersolan Property
- Melting point:
- 34-38°C
- storage temp.
- 2-8°C
- solubility
- H2O: soluble1g/10 mL, clear to faintly turbid, colorless to faintly yellow
- form
- Solid
- color
- White to Pale Yellow Waxy
- InChI
- InChI=1S/C34H56O6/c1-23(2)12-9-13-24(3)14-10-15-25(4)16-11-20-34(8)21-19-29-28(7)32(26(5)27(6)33(29)40-34)39-31(37)18-17-30(36)38-22-35/h23-25,35H,9-22H2,1-8H3
- InChIKey
- WFWQYXBTWIHIIW-UHFFFAOYSA-N
- SMILES
- C(=O)(OC1C(C)=C2CCC(C)(CCCC(CCCC(CCCC(C)C)C)C)OC2=C(C)C=1C)CCC(=O)OCO
- LogP
- 9.745 (est)
Safety
- WGK Germany
- 2
- RTECS
- TR1581200
- HS Code
- 2936.28.0000
N-Bromosuccinimide Price
- Product number
- 57668
- Product name
- D-α-Tocopherol polyethylene glycol 1000 succinate
- Purity
- BioXtra, water soluble vitamin E conjugate
- Packaging
- 5g
- Price
- $88.9
- Updated
- 2024/03/01
- Product number
- 57668
- Product name
- D-α-Tocopherol polyethylene glycol 1000 succinate
- Purity
- BioXtra, water soluble vitamin E conjugate
- Packaging
- 25g
- Price
- $310
- Updated
- 2024/03/01
- Product number
- T3118
- Product name
- α-Tocopherol Polyethylene Glycol Succinate
- Packaging
- 5G
- Price
- $70
- Updated
- 2024/03/01
- Product number
- T3118
- Product name
- α-Tocopherol Polyethylene Glycol Succinate
- Packaging
- 25G
- Price
- $240
- Updated
- 2024/03/01
- Product number
- 08-2180
- Product name
- DL-α-Tocopherol methoxypolyethylene glycol succinate solution (2 wt% in water) TPGS-750-M
- Packaging
- 10ml
- Price
- $23
- Updated
- 2021/12/16
Tocofersolan Chemical Properties,Usage,Production
Chemical Properties
Vitamin E polyethylene glycol succinate is a synthetic product. It is available as a white to light-brown, waxy solid and is practically tasteless. Chemically, it is a mixture composed principally of monoesterified polyethylene glycol 1000, the diesterified polyethylene glycol 1000, free polyethylene glycol 1000, and free tocopherol.
Uses
tocophersolan is an anti-oxidant, this is a water-soluble form of vitamin e.
Uses
Tocofersolan is a polyethylene glycol derivative of α-Tocopherol (T526125). Tocofersolan is a synthetic water-soluble vitamin E unlike its natural counterpart which are fat soluble. Tocofersolan is used in pediatrics in the treatment vitamin E-deficient cholestatic children. Tocofersolan has potential application as a absorption enhancer in drug delivery systems. Typical batch, n = 21
Production Methods
Vitamin E polyethylene glycol succinate is prepared by esterification of the acid group of crystalline D-a-tocopheryl acid succinate by polyethylene glycol 1000.
Pharmaceutical Applications
Vitamin E polyethylene glycol succinate is an esterified vitamin E
(tocopherol) derivative primarily used as a solubilizer or emulsifying
agent because of its surfactant properties. Structurally, it is
amphipathic and hydrophilic, unlike the tocopherols, and therefore
it is a water-soluble derivative that can be used in pharmaceutical
formulations such as capsules, tablets, hot-melt extrusion,
microemulsions, topical products, and parenterals. One of
the most important applications is its use as a vehicle for lipid-based
drug delivery formulations. It can also be used as a source of
vitamin E.
Vitamin E polyethylene glycol succinate has been characterized
with respect to its mechanism of action and studied as a Pglycoprotein
inhibitor.
Biochem/physiol Actions
D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) also known as vitamin E TPGS, is a therapeutic agent for vitamin E deficiency in children, administered during chronic childhood cholestasis. TPGS exerts anti-tumor activity in MCF-7 and breast cancer cells by downregulating anti-apoptotic proteins. TPGS finds its application as an emulsifier in the preparation of poly(lactic-co-glycolic acid) (PLGA) particles for DNA labelling, produces particles of uniform size, high encapsulation efficiency, increases hydrophilicity and prevents aggregation of particles.
Safety
Vitamin E polyethylene glycol succinate has been used at levels of 280 mg/capsule in the product Agenerase (amprenavir), which was dosed at 8 capsules (2240mg vitamin E TPGS) per day. An additional assessment of the safety of vitamin E polyethylene glycol succinate has been published, which includes a report showing no-observed-adverse-effect-level (NOAEL) in rats of 1000 mg/kg/day.
storage
Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.
Incompatibilities
Vitamin E polyethylene glycol succinate is incompatible with strong acids and strong alkalis.
Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops). Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Tocofersolan Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tocofersolan manufacturers
- Product
- Tocofersolan 9002-96-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000 Mt/Year
- Release date
- 2023-08-31
- Product
- Tocofersolan 9002-96-4
- Price
- US $34.00-1.30/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-02
- Product
- Tocofersolan;TPGS 9002-96-4
- Price
- US $1500.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2 tons
- Release date
- 2022-11-01