ChemicalBook > CAS DataBase List > 2-(4-Chlorophenyl)thiazole-5-carbaldehyde

2-(4-Chlorophenyl)thiazole-5-carbaldehyde

Product Name
2-(4-Chlorophenyl)thiazole-5-carbaldehyde
CAS No.
721920-84-9
Chemical Name
2-(4-Chlorophenyl)thiazole-5-carbaldehyde
Synonyms
2-(4-CHLOROPHENYL)THIAZOLE-5-CARBALDEHYDE;2-(4-hydroxyphenyl)thiazole-5-carbaldehyde;5-Thiazolecarboxaldehyde, 2-(4-chlorophenyl)-;2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde
CBNumber
CB8406903
Molecular Formula
C10H6ClNOS
Formula Weight
223.68
MOL File
721920-84-9.mol
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2-(4-Chlorophenyl)thiazole-5-carbaldehyde Property

Boiling point:
377.6±48.0 °C(Predicted)
Density 
1.388±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.14±0.10(Predicted)
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Safety

Risk Statements 
43
Safety Statements 
36/37
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C995265
Product name
2-(4-Chlorophenyl)thiazole-5-carbaldehyde
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
C995265
Product name
2-(4-Chlorophenyl)thiazole-5-carbaldehyde
Packaging
1g
Price
$285
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC149170
Product name
2-(4-Chlorophenyl)thiazole-5-carbaldehyde
Packaging
250mg
Price
$57.5
Updated
2021/12/16
Ark Pharm
Product number
P000168977
Product name
2-(4-Chlorophenyl)thiazole-5-carbaldehyde
Purity
95+%
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC149170
Product name
2-(4-Chlorophenyl)thiazole-5-carbaldehyde
Packaging
500mg
Price
$100
Updated
2021/12/16
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2-(4-Chlorophenyl)thiazole-5-carbaldehyde Chemical Properties,Usage,Production

Synthesis

36437-19-1

2521-24-6

721920-84-9

Step 1. Synthesis of 2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde. 4-Chlorobenzamide (5 g, 29.1 mmol), magnesium bicarbonate pentahydrate (7.06 g, 14.55 mmol) and 2-chloromalonaldehyde (4.65 g, 43.65 mmol) were added to a flask and the reaction was stirred for 3 hr at 60 °C under nitrogen protection. Upon completion of the reaction, the reaction mixture was allowed to pass through a silica plug for rapid column chromatography and washed with ethyl acetate. The solvent was removed by concentration under reduced pressure to afford the target product 2-(4-chlorophenyl)-1,3-thiazole-5-carbaldehyde (6 g, 92% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 10.06 (s, 1H), 8.43 (s, 1H), 7.99-7.96 (m, 2H), 7.49-7.46 (m, 2H).

References

[1] Patent: WO2004/58761, 2004, A1. Location in patent: Page 37-38
[2] Patent: WO2011/12862, 2011, A1. Location in patent: Page/Page column 102; 109

2-(4-Chlorophenyl)thiazole-5-carbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(4-Chlorophenyl)thiazole-5-carbaldehyde manufacturers

Career Henan Chemical Co
Product
2-(4-Chlorophenyl)thiazole-5-carbaldehyde 721920-84-9
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-02