3-Chloro-4-fluorobenzotrifluoride

Product Name: 3-Chloro-4-fluorobenzotrifluoride
CAS No.: 78068-85-6
Chemical Name: 3-Chloro-4-fluorobenzotrifluoride
Synonyms: 2-CHLORO-1-FLUORO-4-(TRIFLUOROMETHYL)BENZENE;3-chloro-4-fluorobezotrilfuoride;3-Cholor-4-Fluorobenzo-Trifluori;-Chloro-4-fluorobenzotrifluoride;3-chloro-4-fluorotrifluorotoluene;3-CHLORO-4-FLUOROBENZOTRIFLUORIDE;3-chloro-4-chlorobenzotrifluoride;3-CHOLOR-4-FLUOROBENZO-TRIFLUORIDE;3-chloro-4-fluorobenzontrifluoride;3-chloro-4-fluorobenzene trifluoro
CBNumber: CB8409111
Molecular Formula: C7H3ClF4
Formula Weight: 198.55
MOL File: 78068-85-6.mol

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3-Chloro-4-fluorobenzotrifluoride Property

Boiling point:: 137℃
Density: 1,49 g/cm³
refractive index: 1.4355
Flash point:: 42°(108°F)
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform, Methanol
form: Oil
color: Clear Colorless
BRN: 4309386
InChI: InChI=1S/C7H3ClF4/c8-5-3-4(7(10,11)12)1-2-6(5)9/h1-3H
InChIKey: BKHVEYHSOXVAOP-UHFFFAOYSA-N
SMILES: C1(F)=CC=C(C(F)(F)F)C=C1Cl
CAS DataBase Reference: 78068-85-6(CAS DataBase Reference)
EPA Substance Registry System: Benzene, 2-chloro-1-fluoro-4-(trifluoromethyl)- (78068-85-6)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36
RIDADR: 1993
Hazard Note: Irritant
TSCA: Yes
HazardClass: 3
PackingGroup: Ⅲ
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1515
Product name: 3-Chloro-4-fluorobenzotrifluoride
Purity: >98.0%(GC)
Packaging: 5g
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: C1515
Product name: 3-Chloro-4-fluorobenzotrifluoride
Purity: >98.0%(GC)
Packaging: 25g
Price: $56
Updated: 2025/07/31

Strem Chemicals

Product number: 09-1863
Product name: 3-Chloro-4-fluorobenzotrifluoride, 98%
Packaging: 10g
Price: $248
Updated: 2024/03/01

Strem Chemicals

Product number: 09-1863
Product name: 3-Chloro-4-fluorobenzotrifluoride, 98%
Packaging: 50g
Price: $949
Updated: 2024/03/01

TRC

Product number: C584910
Product name: 3-Chloro-4-fluorobenzotrifluoride
Packaging: 500mg
Price: $45
Updated: 2021/12/16

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3-Chloro-4-fluorobenzotrifluoride Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Uses

3-Chloro-4-fluorobenzotrifluoride acts as a reagent in the synthesis of β-substituted 3-(4-aryloxyaryl)propanoic acid as GPR40 agonists.

Synthesis

328-84-7

78068-85-6

In a 500 mL four-neck flask equipped with a condenser, 200 mL of N,N-dimethylacetamide (DMA), 0.2 mol of 3,4-dichlorobenzotrifluoride, 1.0 mol of potassium fluoride, and 0.01 mol of tetraphenylphosphine chloride were added. The reaction mixture was heated to 150°C until the gas chromatography (GC) content of the feedstock 3,4-dichlorobenzotrifluoride was less than 1%. Upon completion of the reaction, potassium fluoride and catalyst were recovered by diafiltration for use in the next batch of the reaction. The mother liquor was dissolved and purified by distillation to give 3-chloro-4-fluorobenzotrifluoride in 99% purity and 90% yield.

References

[1] Patent: CN106554289, 2017, A. Location in patent: Paragraph 0025; 0026; 0027; 0030; 0031; 0032; 0035-0037
[2] Gazzetta Chimica Italiana, 1996, vol. 126, # 7, p. 457 - 462
[3] Gazzetta Chimica Italiana, 1996, vol. 126, # 7, p. 457 - 462

3-Chloro-4-fluorobenzotrifluoride Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chloro-4-fluorobenzotrifluoride Suppliers

Americas 1 China 227 Europe 3 France 1 Germany 2 India 12 Italy 1 Japan 1 Slovakia 1 Ukraine 1 United Kingdom 20 United States 39 Global 309

Nanjing webright Pharmaceutical Technology Co., Ltd

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View Lastest Price from 3-Chloro-4-fluorobenzotrifluoride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-Chloro-4-fluorobenzotrifluoride 78068-85-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-01

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-Chloro-4-fluorobenzotrifluoride 78068-85-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-12

Dideu Industries Group Limited

Product: 3-Chloro-4-fluorobenzotrifluoride 78068-85-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2025-04-09

78068-85-6, 3-Chloro-4-fluorobenzotrifluoride Related Search:

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3-Chloro-4-fluorobenzotrifluoride,98%

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78068-85-6

78068-85-8

ClFC6H3CF3

Aromatic Hydrocarbons (substituted) & Derivatives

API intermediates

Trifluoromethylbenzene serise

organofluorine compounds

Fluorine series