5-Amino-1,3-dihydro-2H-benzimidazol-2-one
- Product Name
- 5-Amino-1,3-dihydro-2H-benzimidazol-2-one
- CAS No.
- 95-23-8
- Chemical Name
- 5-Amino-1,3-dihydro-2H-benzimidazol-2-one
- Synonyms
- AKOS BBS-00006487;5-AMINOBENZIMIDAZOLONE;5-Nitro benzimidazolone;Ilaprazole Impurity 170;5-AMINOBENZIMIDAZOLINONE;5(6)-AMINOBENZOIMIDAZOLONE;5-Aminobenzimidazolone,98%;5-AMino-2-enziMidazolinone;5-AMINO-2-BENZIMIDAZOLINONE;5-Amino-1H-benzimidazol-2-ol
- CBNumber
- CB8410489
- Molecular Formula
- C7H7N3O
- Formula Weight
- 149.15
- MOL File
- 95-23-8.mol
5-Amino-1,3-dihydro-2H-benzimidazol-2-one Property
- Melting point:
- >300 °C
- Boiling point:
- 201.4±19.0 °C(Predicted)
- Density
- 1.363±0.06 g/cm3(Predicted)
- vapor pressure
- 0.001Pa at 20℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Powder
- pka
- 11.80±0.30(Predicted)
- color
- White to Amber to Dark purple
- InChI
- InChI=1S/C7H7N3O/c8-4-1-2-5-6(3-4)10-7(11)9-5/h1-3H,8H2,(H2,9,10,11)
- InChIKey
- BCXSVFBDMPSKPT-UHFFFAOYSA-N
- SMILES
- C1(=O)NC2=CC=C(N)C=C2N1
- LogP
- -0.33 at 23℃ and pH6.5-7.5
- CAS DataBase Reference
- 95-23-8(CAS DataBase Reference)
- EPA Substance Registry System
- 2H-Benzimidazol-2-one, 5-amino-1,3-dihydro- (95-23-8)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-36-22
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS003171
- Product name
- 5-Amino-1,3-dihydro-2H-benzimidazol-2-one
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $87.5
- Updated
- 2025/07/31
- Product number
- A1950
- Product name
- 5-Amino-2-benzimidazolinone
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- A1950
- Product name
- 5-Amino-2-benzimidazolinone
- Purity
- >98.0%(HPLC)
- Packaging
- 25g
- Price
- $22
- Updated
- 2025/07/31
- Product number
- A790310
- Product name
- 5-Amino-2-hydroxybenzimidazole
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- A790310
- Product name
- 5-Amino-2-hydroxybenzimidazole
- Packaging
- 10g
- Price
- $200
- Updated
- 2021/12/16
5-Amino-1,3-dihydro-2H-benzimidazol-2-one Chemical Properties,Usage,Production
Chemical Properties
Crystalline powder
Uses
5-Amino-2-hydroxybenzimidazole is an important reagent in the discovery of potent and selective non-nucleotide small molecule inhibitors of CD73
Synthesis
93-84-5
95-23-8
Step: 21b Synthesis of 5-amino-1,3-dihydrobenzimidazol-2-one. Pd/C catalyst (140 mg) was added to a mixed solution of methanol and ethyl acetate containing 5-nitro-1,3-dihydrobenzimidazol-2-one (1.4 g, 7.8 mmol) and the hydrogenation reaction was carried out for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, the unfolding agent was a chloroform solution of 10% methanol). After completion of the reaction, the reaction mixture was filtered through a bed of diatomaceous earth and the filtrate was concentrated to give the target product 5-amino-1,3-dihydrobenzimidazol-2-one (1 g, 86% yield).
References
[1] Patent: WO2012/59932, 2012, A1. Location in patent: Page/Page column 161-162
[2] Patent: WO2009/42907, 2009, A1. Location in patent: Page/Page column 78-79
[3] Journal of the American Chemical Society, 1958, vol. 80, p. 1662
[4] Patent: WO2012/115479, 2012, A2. Location in patent: Page/Page column 23
[5] Patent: CN104151251, 2017, B. Location in patent: Paragraph 0024
5-Amino-1,3-dihydro-2H-benzimidazol-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
5-Amino-1,3-dihydro-2H-benzimidazol-2-one Suppliers
- Tel
- --
- Fax
- --
- sy-ec-marketing@synthesia.cz
- Country
- Czech Republic
- ProdList
- 116
- Advantage
- 68
View Lastest Price from 5-Amino-1,3-dihydro-2H-benzimidazol-2-one manufacturers
- Product
- 5-Amino-1,3-dihydro-2H-benzimidazol-2-one 95-23-8
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-27
- Product
- 5-Amino-1,3-dihydro-2H-benzimidazol-2-one 95-23-8
- Price
- US $30.00-10.00/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 100000kg
- Release date
- 2024-08-20
- Product
- 5-Amino-1,3-dihydro-2H-benzimidazol-2-one 95-23-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10