ChemicalBook > CAS DataBase List > Bleomycin sulfate

Bleomycin sulfate

Product Name
Bleomycin sulfate
CAS No.
9041-93-4
Chemical Name
Bleomycin sulfate
Synonyms
BLEOMYCIN SULPHATE;BLENOXANE;Bleomycin Sulfate (mixture);BLEOMYCIN SULFATE CELL CULTURE TESTED;BLEO;BLEXANE;Bleolem;BLEOcell;BLEO cell;BLEO-cell
CBNumber
CB8412175
Molecular Formula
C110H168N34O46S7
Formula Weight
2927.17
MOL File
9041-93-4.mol
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Bleomycin sulfate Property

Melting point:
200-204°C (dec.)
storage temp. 
2-8°C
solubility 
H2O: 20 mg/mL
form 
powder
color 
white
Water Solubility 
Soluble in water or DMSO
Merck 
14,1318
Stability:
Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.
InChI
InChI=1/2C55H83N17O21S3.H2O4S/c2*1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-66-26)91-54-43(39(80)37(78)28(16-73)90-54)92-53-40(81)42(93-55(60)88)38(79)29(17-74)89-53)51(87)67-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-68-27(18-94-32)52-65-15-30(95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h2*14-15,18-19,21-25,28-29,34-43,53-54,64,73-75,77-81H,7-13,16-17,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,66,67,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t2*21-,22+,23+,24-,25-,28-,29+,34+,35+,36-,37+,38+,39-,40-,41-,42+,43-,53-,54-;/s3
InChIKey
OOXTWFJZZAJGKA-YWZNXBAZNA-N
SMILES
[C@@H](C1N=CNC=1)(O[C@@H]1O[C@H]([C@@H](O)[C@H](O)[C@@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@@H](OC(=O)N)[C@@H]1O)CO)[C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@H]([C@H](O)C)C(=O)NCCC1SC=C(C2=NC=C(C(=O)NCCC[S+](C)C)S2)N=1)NC(=O)C1=C(C)C(=NC([C@H](CC(=O)N)NC[C@H](N)C(=O)N)=N1)N.[C@@H](C1N=CNC=1)(O[C@@H]1O[C@H]([C@@H](O)[C@H](O)[C@@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@@H](OC(=O)N)[C@@H]1O)CO)CO)[C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@H]([C@H](O)C)C(=O)NCCC1SC=C(C2=NC=C(C(=O)NCCC[S+](C)C)S2)N=1)NC(=O)C1=C(C)C(=NC([C@H](CC(=O)N)NC[C@H](N)C(=O)N)=N1)N.S([O-])([O-])(=O)=O |&1:0,7,9,10,12,14,16,18,21,23,28,32,36,38,40,45,46,82,89,96,103,105,106,108,110,112,114,115,117,122,128,132,134,136,141,142,178,185,r|
CAS DataBase Reference
9041-93-4(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
46-40-36/37/38-63
Safety Statements 
53-36/37-45-36-26
WGK Germany 
3
RTECS 
EC5991990
F 
10
HS Code 
2941906000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B8416
Product name
Bleomycin sulfate from Streptomyces verticillus
Purity
1.5-2.0?units/mg solid, BioReagent, suitable for cell culture
Packaging
15units
Price
$1140
Updated
2025/07/31
Sigma-Aldrich
Product number
B5507
Product name
Bleomycin sulfate from Streptomyces verticillus
Purity
crystalline, 1.5-2.0?U/mg
Packaging
15units
Price
$913
Updated
2025/07/31
Sigma-Aldrich
Product number
B2434
Product name
Bleomycin sulfate from Streptomyces verticillus
Purity
BioXtra, crystalline
Packaging
20mg
Price
$1500
Updated
2025/07/31
Sigma-Aldrich
Product number
B1141000
Product name
Bleomycin sulfate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
7 mg
Price
$236
Updated
2025/07/31
Sigma-Aldrich
Product number
1076308
Product name
Bleomycin sulfate
Packaging
15mg
Price
$947
Updated
2025/07/31
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Bleomycin sulfate Chemical Properties,Usage,Production

Description

Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1?and RNA2. Induces double-strand DNA damage.3?Commonly used to induce lung fibrosis in animal disease models.4,5?Anticancer agent in clinical use.6

Chemical Properties

White Powder

Uses

Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at less and more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.

Mechanism of action

Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

brand name

Blenoxane (Bristol-Myers Squibb).

General Description

Bleomycin occurs as a white powder and is available in 15-and 30-U vials for reconstitution in water. It may be givenintravenously, intramuscularly, or subcutaneously. It is used in the treatment of squamous cell carcinoma of the headneck, cervix, penis, and vulva. It is also used in Hodgkin’sand non-Hodgkin’s lymphoma as well as testicular carcinoma.Unlabeled uses include the treatment of mycosis fungoides,osteosarcoma, and AIDS-related Kaposi sarcoma.

Biochem/physiol Actions

Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.

Clinical Use

Bleomycin is used IV in the palliative treatment of squamous cell head and neck cancers, testicular and other genital carcinomas, and Hodgkin's and non-Hodgkin's lymphoma.

Side effects

It is excreted via the kidneys, and serum concentrations of active drug are increased in patients with renal disease. The elimination half-life can rise from 2 to 4 hours to more than 20 hours in renal failure, resulting in significant toxicity, especially pulmonary toxicity.

Veterinary Drugs and Treatments

Bleomycin has occasionally been used as adjunctive treatment of lymphomas, squamous cell carcinomas, teratomas, and nonfunctional thyroid tumors in both dogs and cats. Recent work has demonstrated that bleomycin may be promising for intralesional treatment for a variety of localized tumors with or without concomitant electropermeabilization.

target

UT-SCC-129 cells

References

[1] DAVID H. PETERING  William E A  Robert W Byrnes. The role of redox-active metals in the mechanism of action of bleomycin[J]. Chemico-Biological Interactions, 1990, 73 2: Pages 133-182. DOI:10.1016/0009-2797(90)90001-4
[2] A. HÜTTENHOFER. Cleavage of tRNA by Fe(II)-bleomycin.[J]. The Journal of Biological Chemistry, 1992, 81 1: 24471-24475. DOI:10.1016/s0021-9258(18)35790-9
[3] KYUNG YONG LEE. ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks.[J]. Molecular Cell, 2017, 68 1: 61-75.e5. DOI:10.1016/j.molcel.2017.08.021
[4] YAN XIE. Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis.[J]. Respiratory Research, 2016: 103. DOI:10.1186/s12931-016-0418-4
[5] MINORU INOMATA. Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis.[J]. Respiratory Research, 2014: 16. DOI:10.1186/1465-9921-15-16
[6] TOSHIKO TANAKA. Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells.[J]. Anticancer research, 2008, 28 5A: 2663-2668.

Bleomycin sulfate Preparation Products And Raw materials

Raw materials

Methanol solution Zinc sulphate streptomyces avermifilis Dithizone Potassium Phosphate Monobasic Disodium edetate dihydrate Cation exchange resin,weak acidic acrylic acid corn syrup

Preparation Products

PEPLOMYCIN
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View Lastest Price from Bleomycin sulfate manufacturers

Taizhou Creating Bio-pharm co., ltd.
Product
Bleomycin sulfate 9041-93-4
Price
US $0.00/G
Min. Order
1G
Purity
0.99
Supply Ability
1KG
Release date
2025-06-06
Wuhan JiyunZen Tech Co., Ltd.
Product
Bleomycin sulfate 9041-93-4
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Bleomycin sulfate 9041-93-4
Price
US $0.00-0.00/g
Min. Order
1g
Purity
96.3%
Supply Ability
100g
Release date
2025-05-21

9041-93-4, Bleomycin sulfateRelated Search:

Ethanol Neomycin sulfate Magnesium sulfate heptahydrate Barium sulfate Potassium sulfate Ethyl acetate calcium sulfate Glycine Sodium thiosulfate pentahydrate Sodium sulfate Copper(II) sulfate Ethyl acrylate Aluminum sulfate Ammonium sulfate ALTRENOGEST Ethyl vanillin Ferrous sulfate monohydrate Ferrous sulfate heptahydrate

  • BLEOMYCIN SULFATE CELL CULTURE TESTED
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  • 9041-93-4
  • C110H168N34O46S7
  • C55H84N17O21S3HSO4