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Vagistat

Product Name
Vagistat
CAS No.
65899-73-2
Chemical Name
Vagistat
Synonyms
Trosyl;Trosyd;Zoniden;vagistat;UK-20349;Fungibacid;Vagistat 1;ioconazole;Gyno-Trosyd;TIOCONAZOLE
CBNumber
CB8416704
Molecular Formula
C16H13Cl3N2OS
Formula Weight
387.71
MOL File
65899-73-2.mol
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Vagistat Property

Melting point:
79-81oC
Boiling point:
534.5±50.0 °C(Predicted)
Density 
1.3115 (rough estimate)
refractive index 
1.6000 (estimate)
RTECS 
NI4480000
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Very slightly soluble in water, very soluble in methylene chloride, freely soluble in alcohol.
form 
powder
pka
6.66±0.12(Predicted)
color 
white to off-white
CAS DataBase Reference
65899-73-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
HS Code 
2934990002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2808
Product name
Tioconazole
Packaging
400MG
Price
$170
Updated
2024/03/01
Sigma-Aldrich
Product number
BP687
Product name
Tioconazole impurity standard
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$229
Updated
2024/03/01
Sigma-Aldrich
Product number
BP645
Product name
Tioconazole
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$257
Updated
2024/03/01
Sigma-Aldrich
Product number
1667439
Product name
Tioconazole
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$157.2
Updated
2024/03/01
Sigma-Aldrich
Product number
03907
Product name
Tioconazole
Purity
97%
Packaging
10g
Price
$183
Updated
2024/03/01
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Vagistat Chemical Properties,Usage,Production

Description

Tioconazole is an antifungal agent, closely related to miconazole. Tioconazole is effective in the topical treatment of superficial fungal infections and appears to be more potent than miconazole against Candida and Trichophyton species.

Chemical Properties

White powder EINECS: 265-973-8

Originator

Pfizer (United Kiugdom)

Uses

Potent inhibitor of cytochrome-P450

Uses

Tioconazole is an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical).

Uses

antithrombotic

Definition

ChEBI: A member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2.

Indications

Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, tioconazole is indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.

Manufacturing Process

A solution of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (1.5 g, 5.8 mmol) dissolved in dry tetrahydrofuran (10 ml) was added to a stirred suspension of sodium hydride (0.39 g, as 80% dispersion in oil, 16 mmol) in dry tetrahydrofuran (10 ml) and warmed to 70°C for 90 minutes. The mixture was cooled in ice and a solution of 2-chloro-3- chloromethylthiophene (8.8 mmol) in dry tetrahydrofuran was added. The mixture was heated at 70°C for 3 hours and allowed to stir at room temperature overnight. The solvent was removed under vacuum and the residue stirred with dry ether (200 ml). The ether solution was filtered through Celite and saturated with hydrogen chloride gas to precipitate an oil which was solidified by trituration with ether and ethyl acetate. The solid product was collected and recrystallized from a mixture of acetone and diisopropyl ether to give the product, melting point 168°C to 170°C.

brand name

TROSYL

Therapeutic Function

Antifungal

Antimicrobial activity

Tioconazole is a broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi.

Pharmacokinetics

Tioconazole is normally not absorbed after topical application to the skin [173]. On vaginal application of an ovulum containing 300 mg tioconazole, a serum concentration of 21 μg/mL was observed after 8 h.

Clinical Use

1-[2-[(2-chloro-3-thienyl)methoxy]2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole (Vagistat) is used for the treatment ofvulvovaginal candidiasis. A vaginal ointment containing6.5% of the free base is available. Tioconazole is more effectiveagainst Torulopsis glabrata than are other azoles.

Side effects

Local irritations such as itching, burning sensations, erythema, and dermatitis, and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.

Vagistat Preparation Products And Raw materials

Raw materials

Preparation Products

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Vagistat Suppliers

Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2876
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
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View Lastest Price from Vagistat manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Vagistat 65899-73-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%-101%; EP
Supply Ability
500kg
Release date
2021-11-03
Hebei Weibang Biotechnology Co., Ltd
Product
Vagistat 65899-73-2
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-09-14
Wuhan Han Sheng New Material Technology Co.,Ltd
Product
Vagistat 65899-73-2
Price
US $0.00-0.00/kg
Min. Order
100kg
Purity
99%
Supply Ability
20 tons
Release date
2023-05-24

65899-73-2, VagistatRelated Search:


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  • 1-(2-((2-chloro-3-thienyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazol
  • vagistat
  • TIOCONAZOLE
  • 1-[2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]imidazole
  • 1H-Imidazole, 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]- (9CI)
  • Fungibacid
  • Gyno-Trosyd
  • New Straitus U
  • Trosyd
  • Trosyl
  • Vagistat 1
  • Zoniden
  • 1-(1H-Imidazole-1-yl)-2-(2,4-dichlorophenyl)-2-[(2-chloro-3-thienyl)methoxy]ethane
  • 1-[2,4-Dichloro-β-[(2-chloro-3-thenyl)oxy]phenethyl]-1H-imidazole
  • 1-[2,4-Dichloro-β-[(2-chloro-3-thienyl)methyloxy]phenethyl]-1H-imidazole
  • 1-[β-[(2-Chloro-3-thienyl)methoxy]-2,4-dichlorophenethyl]-1H-imidazole
  • 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
  • Tioconazole (200 mg)
  • TIOCONAZOLE ASSAY STANDARD BP(CRM STANDARD)
  • TIOCONAZOLE BP STANDARD(CRM STANDARD)
  • TIOCONAZOLE FOR SYSTEM SUITABILITY EPY(CRM STANDARD)
  • TIOCONAZOLE USP(CRM STANDARD)
  • Thioconazole
  • 1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
  • 1-[(2S)-2-[(2-chlorothiophen-3-yl)Methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-iMidazole
  • UK-20349
  • Tioconazole, >=99%
  • ioconazole
  • Vagistat sulfate
  • Tioconazole for system suitability CRS
  • 1-[(2RS)-2-[(2-Chlorothiophen-3-yl)methoxy]-2-(2,4- dichlorophenyl)ethyl]-1H-imidazole
  • 1-[(2S)-2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
  • 1-{2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichl orophenyl)ethyl}-1H-imidazole
  • Vagistat USP/EP/BP
  • Tioconazole (UK-20349)
  • Tioconazole (1667439)
  • Thiamethoxam health thiazole
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  • 65889-73-2
  • C16H13Cl3N2OS
  • AGRYLIN
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