Vagistat
- Product Name
- Vagistat
- CAS No.
- 65899-73-2
- Chemical Name
- Vagistat
- Synonyms
- Trosyl;Trosyd;Zoniden;vagistat;UK-20349;Fungibacid;Vagistat 1;ioconazole;Gyno-Trosyd;TIOCONAZOLE
- CBNumber
- CB8416704
- Molecular Formula
- C16H13Cl3N2OS
- Formula Weight
- 387.71
- MOL File
- 65899-73-2.mol
Vagistat Property
- Melting point:
- 79-81oC
- Boiling point:
- 534.5±50.0 °C(Predicted)
- Density
- 1.3115 (rough estimate)
- refractive index
- 1.6000 (estimate)
- RTECS
- NI4480000
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Very slightly soluble in water, very soluble in methylene chloride, freely soluble in alcohol.
- form
- powder
- pka
- 6.66±0.12(Predicted)
- color
- white to off-white
- CAS DataBase Reference
- 65899-73-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- PHR2808
- Product name
- Tioconazole
- Packaging
- 400MG
- Price
- $170
- Updated
- 2024/03/01
- Product number
- BP687
- Product name
- Tioconazole impurity standard
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $229
- Updated
- 2024/03/01
- Product number
- BP645
- Product name
- Tioconazole
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $257
- Updated
- 2024/03/01
- Product number
- 1667439
- Product name
- Tioconazole
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $157.2
- Updated
- 2024/03/01
- Product number
- 03907
- Product name
- Tioconazole
- Purity
- 97%
- Packaging
- 10g
- Price
- $183
- Updated
- 2024/03/01
Vagistat Chemical Properties,Usage,Production
Description
Tioconazole is an antifungal agent, closely related to miconazole. Tioconazole is effective in the topical treatment of superficial fungal infections and appears to be more potent than miconazole against Candida and Trichophyton species.
Chemical Properties
White powder EINECS: 265-973-8
Originator
Pfizer (United Kiugdom)
Uses
Potent inhibitor of cytochrome-P450
Uses
Tioconazole is an antifungal that is more active than Fluconazole (F421000) or Voriconazole (V760000) against Candida glabrata mutant strains. Antifungal (topical).
Uses
antithrombotic
Definition
ChEBI: A member of the class of imidazoles that comprises 2-(2,4-dichlorophenyl)ethylimidazole carrying an additional (2-chloro-3-thienyl)methoxy substituent at position 2.
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, tioconazole is indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.
Manufacturing Process
A solution of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol (1.5 g, 5.8 mmol) dissolved in dry tetrahydrofuran (10 ml) was added to a stirred suspension of sodium hydride (0.39 g, as 80% dispersion in oil, 16 mmol) in dry tetrahydrofuran (10 ml) and warmed to 70°C for 90 minutes. The mixture was cooled in ice and a solution of 2-chloro-3- chloromethylthiophene (8.8 mmol) in dry tetrahydrofuran was added. The mixture was heated at 70°C for 3 hours and allowed to stir at room temperature overnight. The solvent was removed under vacuum and the residue stirred with dry ether (200 ml). The ether solution was filtered through Celite and saturated with hydrogen chloride gas to precipitate an oil which was solidified by trituration with ether and ethyl acetate. The solid product was collected and recrystallized from a mixture of acetone and diisopropyl ether to give the product, melting point 168°C to 170°C.
brand name
TROSYL
Therapeutic Function
Antifungal
Antimicrobial activity
Tioconazole is a broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi.
Pharmacokinetics
Tioconazole is normally not absorbed after topical application to the skin [173]. On vaginal application of an ovulum containing 300 mg tioconazole, a serum concentration of 21 μg/mL was observed after 8 h.
Clinical Use
1-[2-[(2-chloro-3-thienyl)methoxy]2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole (Vagistat) is used for the treatment ofvulvovaginal candidiasis. A vaginal ointment containing6.5% of the free base is available. Tioconazole is more effectiveagainst Torulopsis glabrata than are other azoles.
Side effects
Local irritations such as itching, burning sensations, erythema, and dermatitis, and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.
Vagistat Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Vagistat manufacturers
- Product
- Vagistat 65899-73-2
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%-101%; EP
- Supply Ability
- 500kg
- Release date
- 2021-11-03
- Product
- Vagistat 65899-73-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-09-14
- Product
- Vagistat 65899-73-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 100kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-05-24