5-(N,N-HEXAMETHYLENE)-AMILORIDE
- Product Name
- 5-(N,N-HEXAMETHYLENE)-AMILORIDE
- CAS No.
- 1428-95-1
- Chemical Name
- 5-(N,N-HEXAMETHYLENE)-AMILORIDE
- Synonyms
- hma;Amilo;5-HMA;HMA-5;amipromizide;Hexamethyleneamiloride;5-(N,N-HEXAMETHYLENE)-AMILORIDE;AMILORIDE,5-(N,N-HEXAMETHYLENE)-;HMA (5-(N,N-Hexamethylene)amiloride);5-(N,N-HEXAMETHYLENE)-AMILORIDE USP/EP/BP
- CBNumber
- CB8418632
- Molecular Formula
- C12H18ClN7O
- Formula Weight
- 311.77
- MOL File
- 1428-95-1.mol
5-(N,N-HEXAMETHYLENE)-AMILORIDE Property
- Melting point:
- 224-225 °C
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 3mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL
- form
- A crystalline solid
- pka
- 8.81±0.46(Predicted)
- color
- Light yellow to yellow
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 22-36/37/39-45
- RIDADR
- 2811
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- A9561
- Product name
- 5-(N,N-Hexamethylene)amiloride
- Packaging
- 25mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- A9561
- Product name
- 5-(N,N-Hexamethylene)amiloride
- Packaging
- 100mg
- Price
- $151.2
- Updated
- 2024/03/01
- Product number
- 29788
- Product name
- 5-(N,N-hexamethylene)-Amiloride
- Packaging
- 10mg
- Price
- $72
- Updated
- 2024/03/01
- Product number
- 29788
- Product name
- 5-(N,N-hexamethylene)-Amiloride
- Packaging
- 25mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 29788
- Product name
- 5-(N,N-hexamethylene)-Amiloride
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $290
- Updated
- 2021/12/16
5-(N,N-HEXAMETHYLENE)-AMILORIDE Chemical Properties,Usage,Production
Description
5-(N,N-hexamethylene)-Amiloride (HMA) is a derivative of amiloride with diverse biological activities. It is an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 μM). HMA inhibits the cation-selective ion channel formed by the HIV-1 viral protein Vpu when used at a concentration of 50 μM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu when used at a concentration of 10 μM. It also blocks the cation-selective ion channels formed by the hepatitis C virus (HCV) protein p7. HMA (40 μM) induces necrosis in and reduces the viability of MCF-7, MDA-MB-231, T47D, SK-BR-3, Met-1, and NDL breast cancer cells but not cardiomyocytes or uterine, pulmonary, and renal epithelial cells. HMA protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls.
Definition
ChEBI: A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring.
Biochem/physiol Actions
Inhibitor of Na+/H+ antiport.
5-(N,N-HEXAMETHYLENE)-AMILORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
5-(N,N-HEXAMETHYLENE)-AMILORIDE Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from 5-(N,N-HEXAMETHYLENE)-AMILORIDE manufacturers
- Product
- 5-(N,N-HEXAMETHYLENE)-AMILORIDE 1428-95-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-08