3-CHLORO-1H-INDAZOL-5-AMINE
- Product Name
- 3-CHLORO-1H-INDAZOL-5-AMINE
- CAS No.
- 41330-49-8
- Chemical Name
- 3-CHLORO-1H-INDAZOL-5-AMINE
- Synonyms
- 107594;5-AMINO-3-CHLOROINDAZOLE;3-CHLORO-1H-INDAZOL-5-AMINE;3-chloro-2H-indazol-5-amine;3-Chloro-1H-indazol-5-ylaMine;5-AMINO-3-CHLORO (1H)INDAZOLE;1H-Indazol-5-amine, 3-chloro-;3-Chloro-1H-indazol-5-amine ,97%
- CBNumber
- CB8418829
- Molecular Formula
- C7H6ClN3
- Formula Weight
- 167.6
- MOL File
- 41330-49-8.mol
3-CHLORO-1H-INDAZOL-5-AMINE Property
- Boiling point:
- 408.7±25.0 °C(Predicted)
- Density
- 1.533±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 12.45±0.40(Predicted)
- Appearance
- Light brown to brown Solid
- InChI
- InChI=1S/C7H6ClN3/c8-7-5-3-4(9)1-2-6(5)10-11-7/h1-3H,9H2,(H,10,11)
- InChIKey
- CXLAMAWMZAQBKK-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(N)C=C2)C(Cl)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
H331Toxic if inhaled
H401Toxic to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C413305
- Product name
- 3-chloro-1H-indazol-5-amine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C413305
- Product name
- 3-chloro-1H-indazol-5-amine
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- CS-0051423
- Product name
- 3-Chloro-1H-indazol-5-amine
- Packaging
- 1g
- Price
- $297
- Updated
- 2021/12/16
- Product number
- CS-0051423
- Product name
- 3-Chloro-1H-indazol-5-amine
- Packaging
- 100mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- CS-0051423
- Product name
- 3-Chloro-1H-indazol-5-amine
- Packaging
- 250mg
- Price
- $149
- Updated
- 2021/12/16
3-CHLORO-1H-INDAZOL-5-AMINE Chemical Properties,Usage,Production
Chemical Properties
Red solid
Synthesis
4812-45-7
41330-49-8
The general procedure for the synthesis of 3-chloro-1H-indole-5-aniline using 3-chloro-5-nitro-1H-indazole as starting material was as follows: 1.00 g (5.06 mmol) of 3-chloro-5-nitro-1H-indazole was suspended in 50 mL of ethanol, followed by the addition of 5.71 g (25.3 mmol) of tin chloride dihydrate. The reaction mixture was stirred under reflux conditions overnight. Upon completion of the reaction, saturated aqueous sodium bicarbonate was added to the mixture to neutralize the reaction system, followed by three extractions with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The resulting crude product was ground with 10% butyl methyl ether and the solid product was collected by filtration. A final 544 mg of the target compound was obtained with a purity of 90% and a yield of 58% of the theoretical value.
References
[1] Journal of Chemical Research, Miniprint, 1990, # 11, p. 2601 - 2615
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 26, p. 5663 - 5673
[3] Patent: US2016/52884, 2016, A1. Location in patent: Paragraph 0649-0652
[4] Patent: KR2015/137095, 2015, A. Location in patent: Paragraph 0867-0870
3-CHLORO-1H-INDAZOL-5-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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