6-chloro-1H-indazol-3-amine

Product Name: 6-chloro-1H-indazol-3-amine
CAS No.: 16889-21-7
Chemical Name: 6-chloro-1H-indazol-3-amine
Synonyms: Zinc00154498;Einecs 240-925-9;6-chloro-1H-indazol-3-amine;3-Amino-6-chloro-1H-indazole;1H-Indazol-3-amine, 6-chloro-;6-chloro-1H-indoleazole-3-amine;6-Chloro-1H-Indazol-3-Amine (6-Chloro-1H-Indazol-3-Yl)Amine
CBNumber: CB7932205
Molecular Formula: C7H6ClN3
Formula Weight: 167.6
MOL File: 16889-21-7.mol

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6-chloro-1H-indazol-3-amine Property

Boiling point:: 408.7±25.0 °C(Predicted)
Density: 1.533±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 13.72±0.40(Predicted)
Appearance: Off-white to pale purple Solid
InChI: InChI=1S/C7H6ClN3/c8-4-1-2-5-6(3-4)10-11-7(5)9/h1-3H,(H3,9,10,11)
InChIKey: BPTYMRSBTUERSW-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC(Cl)=C2)C(N)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A616343
Product name: 3-Amino-6-chloro-1H-indazole
Packaging: 100mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0033349
Product name: 3-AMINO-6-CHLORO INDAZOLE
Purity: 95.00%
Packaging: 1G
Price: $1016.4
Updated: 2021/12/16

Ambeed

Product number: A557063
Product name: 3-Amino-6-chloro-1H-indazole
Purity: 97%
Packaging: 250mg
Price: $26
Updated: 2021/12/16

Ambeed

Product number: A557063
Product name: 3-Amino-6-chloro-1H-indazole
Purity: 97%
Packaging: 1g
Price: $63
Updated: 2021/12/16

Ambeed

Product number: A557063
Product name: 3-Amino-6-chloro-1H-indazole
Purity: 97%
Packaging: 5g
Price: $158
Updated: 2021/12/16

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6-chloro-1H-indazol-3-amine Chemical Properties,Usage,Production

Uses

Starting from 6-chloro-1H-indazol-3-amine, the EDC/HOAt promoted coupling with the (S)-carboxylic acid derivative furnished (S)-1-(3-Amino-6-chloro-1H-indazol-1-yl)-2-methyl-3-phenoxypro-pan-1-one. This synthesis was performed to explore the structure-activity relationships (SAR) by substituting the indazole scaffold at the 6-position with a chlorine atom, facilitating the identification of novel CFTR potentiators.^[1]

References

[1] Liu, F., Kaplan, A. L., Levring, J., Einsiedel, J., Tiedt, S., Distler, K., Omattage, N. S., Kondratov, I. S., Moroz, Y. S., Pietz, H. L., Irwin, J. J., Gmeiner, P., Shoichet, B. K., & Chen, J. (2024). Structure-based discovery of CFTR potentiators and inhibitors. Cell, 42 1. https://doi.org/10.1016/j.cell.2024.04.046

6-chloro-1H-indazol-3-amine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide N-Methyl-2-pyrrolidone Hydrazine hydrate Thionyl chloride 2,4-Dichlorobenzoic acid

Preparation Products

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6-chloro-1H-indazol-3-amine Suppliers

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16889-21-7, 6-chloro-1H-indazol-3-amineRelated Search:

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6-Chloro-1H-Indazol-3-Amine (6-Chloro-1H-Indazol-3-Yl)Amine

Zinc00154498

6-chloro-1H-indazol-3-amine

Einecs 240-925-9

3-Amino-6-chloro-1H-indazole

1H-Indazol-3-amine, 6-chloro-

6-chloro-1H-indoleazole-3-amine

16889-21-7