Oxazole Property

Melting point:

−87-−84 °C(lit.)

Boiling point:

69-70 °C(lit.)

Density 

1.05 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.425(lit.)

Flash point:

66 °F

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform, Methanol (Slightly)

pka

0.8(at 33℃)

form 

clear liquid

color 

Colorless to Almost colorless

Water Solubility 

Miscible with alcohol and ether. Slightly miscible with water.

BRN 

103851

LogP

0.120

CAS DataBase Reference

288-42-6(CAS DataBase Reference)

NIST Chemistry Reference

Oxazole(288-42-6)

Safety

Hazard Codes 

F,Xi

Risk Statements 

11-41-36/37/38

Safety Statements 

16-26-36-37/60

RIDADR 

UN 1993 3/PG 1

WGK Germany 

3

HazardClass 

3

PackingGroup 

II

HS Code 

29349990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H318Causes serious eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Oxazole Chemical Properties,Usage,Production

Description

Oxazole is the primary compound for a various class of heterocyclic aromatic organic compounds, which include azoles with a nitrogen and an oxygen separated by one carbon. Oxazole is a weak base and an aromatic compound.

Preparation

There are various methods of synthesizing oxazole in organic chemistry including Van Leusen reaction with TosMIC and aldehydes, Robinson-Gabriel preparation by dehydration of 2-acylaminoketones, and Bredereck reaction with formamide. Oxazole result from the oxidation and cyclization of threonine and serine non-ribosomal peptides.

Chemical Properties

Colorlesstolightyellowliqui

Uses

Oxazole and its derivatives are actively involved as building blocks for bio chemicals and pharmaceuticals like flopristin and darglitazone. It is also involved in industrial applications such as in dyes, fluorescent brightening agents, textile auxiliaries and plastics.

Definition

ChEBI: A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.

Definition

oxazole: A heterocyclic compoundhaving a nitrogen atom and an oxygenatom in a five-membered ring,C₃H₃NO.

General Description

Oxazole ring is present in various natural products. The diradical interactions in the ring-opening reaction of oxazole were studied.