ChemicalBook > CAS DataBase List > H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT

H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT

Product Name: H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT
CAS No.: 23815-89-6
Chemical Name: H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT
Synonyms: RPPGF;1-5-Bradykinin;BRADYKININ (1-5);ARG-PRO-PRO-GLY-PHE;1-5-Bradykinin (9CI);Arg-Pro-Pro-Gly-Phe-OH;BRADYKININ FRAGMENT 1-5;39: PN: WO0112656 SEQID;H-Arg-Pro-Pro-Gly-Phe-OH;ARG-PRO-PRO-GLY-PHE ACETATE
CBNumber: CB8420710
Molecular Formula: C27H40N8O6
Formula Weight: 572.66
MOL File: 23815-89-6.mol

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H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Property

Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO
pka: 3.50±0.10(Predicted)
form: Solid
color: White to off-white
Sequence: Arg-Pro-Pro-Gly-Phe

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B1401
Product name: Bradykinin Fragment 1-5
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $83.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: B1401
Product name: Bradykinin Fragment 1-5
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $293
Updated: 2025/07/31

ChemScene

Product number: CS-0044432
Product name: Bradykinin (1-5)
Purity: ≥99.0%
Packaging: 1mg
Price: $50
Updated: 2021/12/16

Chem-Impex

Product number: 32962
Product name: Bradykinin(1-5)trifluoroacetatesalt
Packaging: 5MG
Price: $65.23
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB73292
Product name: Bradykinin (1-5)
Packaging: 2mg
Price: $85
Updated: 2021/12/16

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H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Chemical Properties,Usage,Production

Uses

Biologically active fragment of bradykinin

Biochem/physiol Actions

The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurring metabolites. It may be used as a marker for BK production in vivo. It is known that an intact Arg residue in the C-terminus is required for biological activities. BK 1-5 is the minimal peptide that inhibited α-thrombin-induced platelet aggregation and secretion and calcium mobilization. It also prevented α-thrombin from cleaving the thrombin receptor peptide, NATLDPRSFLLR, between arginine and serine. Such antithrombin activities of BK 1-5 may contribute to the cardioprotective nature of kinins.

in vivo

Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s, that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5), the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (P<0.01 versus baseline). Bradykinin (1-5) inhibits γ-thrombin-induced platelet aggregation 50% at a calculated dose of 183±3 pmol/min. Neither Bradykinin nor Bradykinin (1-5) affects thrombin receptor-activating peptide-induced platelet aggregation, consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide. Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500 nM)-induced platelet aggregation with an ED₅₀ of 183±2 pmol/min^[1].

H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT manufacturers

Career Henan Chemical Co

Product: ARG-PRO-PRO-GLY-PHE 23815-89-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

23815-89-6, H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALTRelated Search:

ANGIOTENSIN I/II (4-8) ANGIOTENSIN II, HUMAN H-ARG-PRO-PRO-GLY-PHE-SER-PRO-OH ACETATE SALT H-MET-LYS-ARG-SER-ARG-GLY-PRO-SER-PRO-ARG-ARG-OH Angiotensin acetate ANGIOTENSIN I/II (1-6) ASP-ARG-VAL-TYR (DES-ASP1,ILE8)-ANGIOTENSIN II ANGIOTENSIN I/II (3-7) ABZ-GLY-4-NITRO-PHE-PRO-OH ANGIOTENSIN I/II (1-5) Angiogenin (108-122) TFA BRADYKININ (1-6) H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH ANGIOTENSINOGEN (1-13) (HUMAN) (SAR1,ILE4,8)-ANGIOTENSIN II ANGIOTENSIN III, HUMAN ANGIOTENSIN 1/2 + A (2 - 8)

RPPGF

ARG-PRO-PRO-GLY-PHE

ARG-PRO-PRO-GLY-PHE ACETATE

BRADYKININ (1-5)

BRADYKININ FRAGMENT 1-5

H-ARG-PRO-PRO-GLY-PHE-OH TFA

H-ARG-PRO-PRO-GLY-PHE-OH TRIFLUOROACETATE SALT

H-Arg-Pro-Pro-Gly-Phe-OH

Arg-Pro-Pro-Gly-Phe-OH

L-Arg-L-Pro-L-Pro-Gly-L-Phe-OH

1-5-Bradykinin

39: PN: WO0112656 SEQID

Bradykinin (1-5) trifluoroacetate salt H-Arg-Pro-Pro-Gly-Phe-OH trifluoroacetate salt

Bradykinin Fragment 1-5, ≥97% (HPLC)

N5-(Diaminomethylene)-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanine

1-5-Bradykinin (9CI)

(S)-2-(2-((S)-1-((S)-1-((S)-2-Amino-5-guanidinopentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)acetamido)-3-phenylpropanoic acid

Bradykinin Fragment 1-5，TFA

23815-89-6

C27H40N8O6

Bradykinins

Amino Acids and Peptides

Biochemicals and Reagents

BioChemical

Peptides

Peptide