ROQUEFORTINE C
- Product Name
- ROQUEFORTINE C
- CAS No.
- 58735-64-1
- Chemical Name
- ROQUEFORTINE C
- Synonyms
- Nsc292134;Aids031208;ROQUEFORTIN;Aids-031208;RORIFONE95%;ROQUEFORTINE;ROQUEFORTINE C;ISOROQUEFORTINE C;Roquefortine C in Methanol;PYRAZINO1215PYRROLO23BINDOLE143H5AH
- CBNumber
- CB8422875
- Molecular Formula
- C22H23N5O2
- Formula Weight
- 389.45
- MOL File
- 58735-64-1.mol
ROQUEFORTINE C Property
- Melting point:
- 202-205℃
- Boiling point:
- 768.3±60.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- chloroform: soluble1mg/mL
- form
- White to off-white solid.
- pka
- 11.10±0.40(Predicted)
- color
- White to off-white
- Stability:
- Hygroscopic
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 22-36/37/39-45
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 3
- RTECS
- UQ4730500
- HS Code
- 2941900000
- Hazardous Substances Data
- 58735-64-1(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- SML0406
- Product name
- Roquefortine C
- Purity
- ≥98% (HPLC), from Penicillium roqueforti
- Packaging
- 500μg
- Price
- $555
- Updated
- 2024/03/01
- Product number
- 15376
- Product name
- Roquefortine C
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- 15376
- Product name
- Roquefortine C
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $305
- Updated
- 2024/03/01
- Product number
- 207386
- Product name
- Roquefortine C
- Packaging
- 500ug
- Price
- $316
- Updated
- 2021/12/16
- Product number
- R2999-45
- Product name
- Roquefortine C
- Packaging
- 500ug
- Price
- $523
- Updated
- 2021/12/16
ROQUEFORTINE C Chemical Properties,Usage,Production
Description
Roquefortine C is a mycotoxin that was first isolated from a strain of P. roqueforti, a species of Penicillium commercially used to ripen blue-
Description
The third alkaloid isolated from a surface culture of Penicillium roqueforti, roquefortine C is present in only small quantities and the amount obtained is insufficient for the full structure to be established.
Uses
Roquefortine C is a potent tremorgenic mycotoxin originally isolated from Penicillium roqueforti in 1975 in Japan. Parallel research by Scott and colleagues lead to the structure elucidation of roquefortine C as an unusual diketopiperazine formed by coupling a prenylated tryptophan and histidine. Roquefortine C was subsequently found to be produced by a diverse range of fungi, most notably Penicillium species. Roquefortine is an important mycotoxin as low levels can be found in foodstuffs.
Uses
Roquefortine C has been used as a standard for the quantification of roquefortine C by high-performance liquid chromatography (HPLC). It has also been used as a standard for the quantification of roquefortine C by liquid chromatography-mass spectrometry (LC?MS/MS).
Definition
ChEBI: Roquefortine C is a pyrroloindole.
Biochem/physiol Actions
Roquefortine C is a paralytic neurotoxin of a dioxopiperazine structure produced by a diverse range of fungi, most notably Penicillium species. It has been found in blue cheese and in many other food products due to natural occurrence and contamination. Roquefortine C was found to be active on a wide range of organisms. It inhibits the growth of Gram-positive bacteria, and cockerels treated with roquefortine lost their righting reflex and died within 8-12 hours. Mice injected with roquefortine C experienced neurotoxic properties. Roquefortine C was also reported to inhibit cytochrome P450 as well as tubulin polymerization.
References
Ohmono et al., Agr. Bioi. Chem., 39, 1333 (1975)
ROQUEFORTINE C Preparation Products And Raw materials
Raw materials
Preparation Products
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