Chlordecone Property

Melting point:

350℃ (DEC.)

Boiling point:

450.5±45.0 °C(Predicted)

Density 

2.27

vapor pressure 

2.25 x 10^-7 mmHg at 25 °C (Kilzer et al., 1979)

Flash point:

>100 °C

storage temp. 

0-6°C

solubility 

Soluble in acetic acid, alcohols, and ketones (Windholz et al., 1983)

form 

Tan to white crystalline solid

Water Solubility 

(mg/L):
7.600 at 24 °C (shake flask-nephelometry, Hollifield, 1979)
2.7 at 20–25 °C (Kilzer et al., 1979)

Merck 

13,2098

Henry's Law Constant

(x 10^-2 atm?m³/mol): 3.11 at 25 °C (approximate - calculated from experimentally determined water solubility and vapor pressure values)

Exposure limits

NIOSH REL: TWA 1 mg/m3.

IARC

2B (Vol. 20, Sup 7) 1987

EPA Substance Registry System

Chlordecone (143-50-0)

Safety

Hazard Codes 

T,N

Risk Statements 

24/25-40-50/53

Safety Statements 

22-36/37-45-60-61

RIDADR 

2761

OEB

E

OEL

TWA: 0.001 mg/m3

RTECS 

PC8575000

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

143-50-0(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 125 mg/kg (Gaines)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H351Suspected of causing cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P501Dispose of contents/container to..…

Chlordecone Chemical Properties,Usage,Production

Description

Chemically, kepone is a chlorinated polycyclic insecticide and fungicide. Chlordecone was used as an insecticide for leaf-eating insects, ants, and cockroaches; as a larvicide for flies; and for control of insects that attack structures. Chlordecone was also used on bananas, nonbearing citrus trees, tobacco, ornamental shrubs, lawns, turf, and flowers. The dry powder is readily absorbed through the skin and respiratory tract. Occupational workers handling kepone without appropriate workplace safety dress and PPE suffered chemical poisoning. The symptoms included, tremors, jerky eye movements, memory loss, headaches, slurred speech, unsteadiness, lack of coordination, loss of weight, rash, enlarged liver, decreased libido, sterility, chest pain, and arthralgia (sharp pain, extending along a nerve or group of nerves, experienced in a joint and/or joints). Chlordecone was first introduced as a pesticide in 1958 and was used until 1978, when its use in the United States was discontinued (NCI 1976, IARC 1979, HSDB 2009).

Chemical Properties

Kerosene is a white to pale yellow, flammable liquid that has wide use in household and industrial activities. For instance, in heating, as cooking fuel, in cleaning, degreasing, as a solvent, for paints, enamels, polishes, varnishes, and in asphalt coating.

Chemical Properties

Kepone is a tan to white, odorless crystalline solid.

Physical properties

Colorless to tan, odorless, noncombustible, crystalline solid

Uses

Formerly as insecticide, fungicide.

Uses

Insecticide; fungicide.

Uses

Chlordecone, a chlorinated dicyclodiene compound, was introduced under the trade name Kepone in 1958. In the United States, Kepone found use as an ant and cockroach poison. Outside the United States, it was used primarily as a pesticide against the banana root borer. The compound is the ketone analog of mirex; it is a contaminant of mirex and is also a product of mirex degradation.

Definition

ChEBI: An organochlorine compound with insecticidal activity.

General Description

Odorless colorless crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Health Hazard

INHALATION AND INGESTION: These symptoms present in all affected patients - Neurologic Impairment - anxiety, irritability, memory disturbance, headache, tremors, opsiclonus, stuttering, slurred speech, and abnormal tandem gait.

Health Hazard

Kerosene toxicity is variable and is based on the composition. It is rapidly absorbed by the skin and accidental ingestion results in mucous membrane irritation, gastrointestinal irritation, vomiting, diarrhea, pneumonitis, CNS depression, drowsiness, coma, and may lead to death. Prolonged contact is also known to cause skin blisters and dermatitis. Studies with non-human primates have demonstrated that aerosols and kerosene aspiration into the lungs cause cellular damage. Household activities and possible long-term exposures to kerosine require proper care to avoid skin contact and possible damage. Kerosene should never be sucked by mouth.

Fire Hazard

Flash point data for KEPONE (TM) are not available; however, KEPONE (TM) is probably combustible.

Potential Exposure

Kepone was registered for the control of rootborers on bananas with a residue tolerance of 0.01 ppm. This constituted the only food or feed use of Kepone. Nonfood uses included wireworm control in tobacco fields and bait to control ants and other insects in indoor and outdoor areas. A rebuttable presumption against registration of chlordecone was issued by the United States Environmental Protection Agency on March 25, 1976 on the basis of oncogenicity. The trademarked Kepone and products of six formulations were the subject of voluntary cancellation according to a United States Environmental Protection Agency notice dated July 27, 1977. In a series of decisions, the first of which was issued on June 17, 1976, the EPA effectively canceled all registered products containing Kepone as of May 1, 1978.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Speed in removing material from skinis of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If thischemical has been inhaled, remove from exposure, beginrescue breathing (using universal precautions, includingresuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Qualified medical personne may consider the administrationof cholestyramine resin (QUESTRAN). Medical personnelshould wear Neoprene? gloves as protection against contamination (Dreisbach).

Carcinogenicity

Kepone (chlordecone) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Photolytic. Kepone-contaminated soils from a site in Hopewell, VA were analyzed by GC/MS. 8-Chloro and 9-chloro homologs identified suggested these were photodegradation products of kepone (Borsetti and Roach, 1978). Products identified from the photolysis of kepone in cyclohexane were 1,2,3,4,6,7,9,10,10-nonachloro-5,5-dihydroxypentacyclo[ 5.3.0.02,6.03,9.04,8]decane for the hydrate and 1,2,3,4,6,7,9,10,10-nonachloro-5,5- dimethoxypentacyclo[5.3.0.02,6.03,9.04,8]decane (Alley et al., 1974).
Chemical/Physical. Readily reacts with moisture forming hydrates (Hollifield, 1979). Decomposes at 350°C (Windholz et al., 1983) probably emitting toxic chlorine fumes.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with Keponeyou should be trained on its proper handling and storage. Aregulated, marked area should be established where thischemical is handled, used, or stored in compliance withOSHA Standard 1910.1045. Store in a cool, dry place in arefrigerator under inert atmosphere. Keep away fromacids and acid fumes.

Shipping

UN2761 Organochlorine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Incompatibilities

Acids, acid fumes.

Waste Disposal

A process has been developed which effects chlordecone degradation by treatment of aqueous wastes with UV radiation in the presence of hydrogen in aqueous sodium hydroxide solution. Up to 95% decomposition was effected by this process. Chlordecone previously presented serious disposal problems because of its great resistance to bio- and photo degradation in the environment. It is highly toxic to normally occur in degrading microorganisms. Although it can undergo some photodecomposition when exposed to sunlight to the dihydro compound (leaving a compound with 8 chloro substituents) that degradation product does not significantly reduce toxicity. Disposal by incineration with HCl scrubbing is recommended.