ChemicalBook > CAS DataBase List > Chlordecone

Chlordecone

Product Name
Chlordecone
CAS No.
143-50-0
Chemical Name
Chlordecone
Synonyms
Merex;KEPONE;GC-1189;o-4-one;ent16,391;ENT-16391;KEPONE(R);ENT 16,391;hlordecane;CHLORDECON
CBNumber
CB8426282
Molecular Formula
C10Cl10O
Formula Weight
490.64
MOL File
143-50-0.mol
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Chlordecone Property

Melting point:
350℃ (DEC.)
Boiling point:
450.5±45.0 °C(Predicted)
Density 
2.27
vapor pressure 
2.25 x 10-7 mmHg at 25 °C (Kilzer et al., 1979)
Flash point:
>100 °C
storage temp. 
0-6°C
solubility 
Soluble in acetic acid, alcohols, and ketones (Windholz et al., 1983)
form 
Tan to white crystalline solid
Water Solubility 
(mg/L):
7.600 at 24 °C (shake flask-nephelometry, Hollifield, 1979)
2.7 at 20–25 °C (Kilzer et al., 1979)
Merck 
13,2098
Henry's Law Constant
(x 10-2 atm?m3/mol): 3.11 at 25 °C (approximate - calculated from experimentally determined water solubility and vapor pressure values)
Exposure limits
NIOSH REL: TWA 1 mg/m3.
IARC
2B (Vol. 20, Sup 7) 1987
EPA Substance Registry System
Chlordecone (143-50-0)
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Safety

Hazard Codes 
T,N
Risk Statements 
24/25-40-50/53
Safety Statements 
22-36/37-45-60-61
RIDADR 
2761
OEB
E
OEL
TWA: 0.001 mg/m3
RTECS 
PC8575000
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
143-50-0(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 125 mg/kg (Gaines)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H351Suspected of causing cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
C368558
Product name
Chlordecone
Packaging
5mg
Price
$85
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003076
Product name
KEPONE
Purity
95.00%
Packaging
100MG
Price
$791.7
Updated
2021/12/16
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Chlordecone Chemical Properties,Usage,Production

Description

Chemically, kepone is a chlorinated polycyclic insecticide and fungicide. Chlordecone was used as an insecticide for leaf-eating insects, ants, and cockroaches; as a larvicide for flies; and for control of insects that attack structures. Chlordecone was also used on bananas, nonbearing citrus trees, tobacco, ornamental shrubs, lawns, turf, and flowers. The dry powder is readily absorbed through the skin and respiratory tract. Occupational workers handling kepone without appropriate workplace safety dress and PPE suffered chemical poisoning. The symptoms included, tremors, jerky eye movements, memory loss, headaches, slurred speech, unsteadiness, lack of coordination, loss of weight, rash, enlarged liver, decreased libido, sterility, chest pain, and arthralgia (sharp pain, extending along a nerve or group of nerves, experienced in a joint and/or joints). Chlordecone was first introduced as a pesticide in 1958 and was used until 1978, when its use in the United States was discontinued (NCI 1976, IARC 1979, HSDB 2009).

Chemical Properties

Kerosene is a white to pale yellow, flammable liquid that has wide use in household and industrial activities. For instance, in heating, as cooking fuel, in cleaning, degreasing, as a solvent, for paints, enamels, polishes, varnishes, and in asphalt coating.

Chemical Properties

Kepone is a tan to white, odorless crystalline solid.

Physical properties

Colorless to tan, odorless, noncombustible, crystalline solid

Uses

Formerly as insecticide, fungicide.

Uses

Insecticide; fungicide.

Uses

Chlordecone, a chlorinated dicyclodiene compound, was introduced under the trade name Kepone in 1958. In the United States, Kepone found use as an ant and cockroach poison. Outside the United States, it was used primarily as a pesticide against the banana root borer. The compound is the ketone analog of mirex; it is a contaminant of mirex and is also a product of mirex degradation.

Definition

ChEBI: An organochlorine compound with insecticidal activity.

General Description

Odorless colorless crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Health Hazard

INHALATION AND INGESTION: These symptoms present in all affected patients - Neurologic Impairment - anxiety, irritability, memory disturbance, headache, tremors, opsiclonus, stuttering, slurred speech, and abnormal tandem gait.

Health Hazard

Kerosene toxicity is variable and is based on the composition. It is rapidly absorbed by the skin and accidental ingestion results in mucous membrane irritation, gastrointestinal irritation, vomiting, diarrhea, pneumonitis, CNS depression, drowsiness, coma, and may lead to death. Prolonged contact is also known to cause skin blisters and dermatitis. Studies with non-human primates have demonstrated that aerosols and kerosene aspiration into the lungs cause cellular damage. Household activities and possible long-term exposures to kerosine require proper care to avoid skin contact and possible damage. Kerosene should never be sucked by mouth.

Fire Hazard

Flash point data for KEPONE (TM) are not available; however, KEPONE (TM) is probably combustible.

Potential Exposure

Kepone was registered for the control of rootborers on bananas with a residue tolerance of 0.01 ppm. This constituted the only food or feed use of Kepone. Nonfood uses included wireworm control in tobacco fields and bait to control ants and other insects in indoor and outdoor areas. A rebuttable presumption against registration of chlordecone was issued by the United States Environmental Protection Agency on March 25, 1976 on the basis of oncogenicity. The trademarked Kepone and products of six formulations were the subject of voluntary cancellation according to a United States Environmental Protection Agency notice dated July 27, 1977. In a series of decisions, the first of which was issued on June 17, 1976, the EPA effectively canceled all registered products containing Kepone as of May 1, 1978.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Speed in removing material from skinis of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If thischemical has been inhaled, remove from exposure, beginrescue breathing (using universal precautions, includingresuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Qualified medical personne may consider the administrationof cholestyramine resin (QUESTRAN). Medical personnelshould wear Neoprene? gloves as protection against contamination (Dreisbach).

Carcinogenicity

Kepone (chlordecone) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Photolytic. Kepone-contaminated soils from a site in Hopewell, VA were analyzed by GC/MS. 8-Chloro and 9-chloro homologs identified suggested these were photodegradation products of kepone (Borsetti and Roach, 1978). Products identified from the photolysis of kepone in cyclohexane were 1,2,3,4,6,7,9,10,10-nonachloro-5,5-dihydroxypentacyclo[ 5.3.0.02,6.03,9.04,8]decane for the hydrate and 1,2,3,4,6,7,9,10,10-nonachloro-5,5- dimethoxypentacyclo[5.3.0.02,6.03,9.04,8]decane (Alley et al., 1974).
Chemical/Physical. Readily reacts with moisture forming hydrates (Hollifield, 1979). Decomposes at 350°C (Windholz et al., 1983) probably emitting toxic chlorine fumes.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with Keponeyou should be trained on its proper handling and storage. Aregulated, marked area should be established where thischemical is handled, used, or stored in compliance withOSHA Standard 1910.1045. Store in a cool, dry place in arefrigerator under inert atmosphere. Keep away fromacids and acid fumes.

Shipping

UN2761 Organochlorine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Incompatibilities

Acids, acid fumes.

Waste Disposal

A process has been developed which effects chlordecone degradation by treatment of aqueous wastes with UV radiation in the presence of hydrogen in aqueous sodium hydroxide solution. Up to 95% decomposition was effected by this process. Chlordecone previously presented serious disposal problems because of its great resistance to bio- and photo degradation in the environment. It is highly toxic to normally occur in degrading microorganisms. Although it can undergo some photodecomposition when exposed to sunlight to the dihydro compound (leaving a compound with 8 chloro substituents) that degradation product does not significantly reduce toxicity. Disposal by incineration with HCl scrubbing is recommended.

Chlordecone Preparation Products And Raw materials

Raw materials

Preparation Products

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Chlordecone Suppliers

Canada 2 China 22 France 1 Germany 2 India 1 Japan 2 South Korea 1 Switzerland 1 United Kingdom 3 United States 14 Global 49
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
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China
ProdList
11707
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Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
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China
ProdList
9658
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
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China
ProdList
25003
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TianJin Alta Scientific Co., Ltd.
Tel
022-65378550-8551
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2773
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58
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9941
Advantage
58
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
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China
ProdList
9998
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58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
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China
ProdList
57412
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58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
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58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22963
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58
ShangHai Anpel Co, Ltd.
Tel
18501792038; 18501792038
Email
shanpel@anpel.com.cn
Country
China
ProdList
9611
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58
Antai Fine Chemical Technology Co.,Limited
Tel
18503026267
Email
info@antaichem.com
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CHINA
ProdList
9636
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58
Qingdao Tenglong microwave technology co., LTD.
Tel
0532-83818797 18561885118
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market@tlwb.com.cn
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Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
15229059051
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1027@dideu.com
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China
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9992
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58
Shanghai isotope chemical co.,ltd
Tel
021-021-51600108 13062666369
Email
sales@chinaisotope.com
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China
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4271
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58
Tel
4008-099-669
Email
23419001name@qq.com
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CHINA
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70071
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58
Tel
58896805
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7993601name@qq.com
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CHINA
ProdList
15092
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58
Shaanxi Didu New Materials Co. Ltd
Tel
+86-89586680 +86-13289823923
Email
1026@dideu.com
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China
ProdList
8670
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58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
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CHINA
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6650
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Shanghai Haoran Biotechnology Co., Ltd.
Tel
--
Fax
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470003480@QQ.COM
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6955
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Shanghai Jingke Chemical Technology Co., Ltd.
Tel
--
Fax
--
Email
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CHINA
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6972
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Beijing Shengke Boyuan Biotechnology Co., Ltd.
Tel
--
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978560024@qq.com
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6005
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58

143-50-0, ChlordeconeRelated Search:

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  • 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-1,3,4-metheno-2h-cyclobuta(cd)pe
  • 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
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  • 1,2,3,4,5,5,6,7,8,9,10,10-dodecachlorooctahydro-1,3,4-metheno-2-cyclobuta-(c,d)
  • 1,2,3,5,6,7,8,9,10,10-decachloro(5.2.1.0(sup2,6).0(sup3,9).0(sup5,8))decan
  • 1,2,3,5,6,7,8,9,10,10-Decachloro(5.2.1.0<sup>2,6</sup>.0<sup>3,9</sup> .0<sup>5,8</sup>)decan-4-one
  • 1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro-
  • decachloropentacyclo(5.2.1.0(2,6).0(3,9).0(5),(8))decan-4-one
  • decachloropentacyclo(5.2.1.0(sup2,6).0(sup3,9).0(sup5,8))decan-4-one
  • decachloropentacyclo(5.3.0.0(sup2,6).0(sup4,10).0(sup5,9))decan-3-one
  • Decachloropentacyclo(5.3.0.0<sup>2,6</sup>.0<sup>4,10</sup>.0<sup>5,9</sup>)decan-3-one
  • Decachloropentacyclo[5.2.1.0(2,6).0(3,9).0(5,8)]decan-4-one
  • Decachloropentacyclo[5.2.1.0(sup2,6).0(sup3,9).0(sup5,8)]decan-4-one
  • Decachlorotetracyclodecanone
  • decachlorotetrahydro-4,7-methanoindeneone
  • decachlorpentacyclo (5.2.1.0(2,6).0(3,9).0(5,8)) decan-4-one
  • ENT 16,391
  • ent16,391
  • ENT-16391
  • General chemicals 1189
  • generalchemicals1189
  • hlordecane
  • Kepone-2-one, decachlorooctahydro-
  • rcrawastenumberu142
  • talen-2-one
  • CHLORDECON PESTANAL (DECACHLORO- PENTACY
  • KEPONE
  • KEPONE(R)
  • KEPONE (TM)
  • chlordecone hydrate (bsi,iso)
  • Chlordeconehydrate(Kepone)
  • chlordecone (ISO) perchloropentacyclo[5,3,0,02,6,03,9,04,8]decan-5-one decachloropentacyclo[5,2,1,02,6,03,9,05,8]decan-4-one
  • Chlordecone, Perchloropentacyclo[5.3.0.02,6.03,9.04,8]decan-5-one
  • Chlordecone, KeponeTM, Perchloropentacyclo[5.3.0.02,6.03,9.04,8]decan-5-one
  • Kepone (TM) 50mg [143-50-0]
  • KEPONE (A.K.A. CHLORDECONE)
  • Chlordecone(content>15%)
  • Chlordecone emulsion(content>4%)
  • CHLORDECON
  • CHLORDECONE
  • DECACHLOROOCTAHYDRO-1,3,4-METHENO-2 H,5 H-CYCLOBUTA [C,D] PENTALEN-2-ONE
  • DECACHLORO OCTAHYDRO-1,3,4-METHENO-2H-CYCLOBUTA[CD]-PENTALEN-2-ONE
  • GC-1189
  • KEPONE, 50MG, NEAT
  • KEPONE, 100MG, NEAT
  • 1,3,4-metheno-2h-cyclobuta(cd)pentalen-2-one,1,1a,3,3a,4,5,5,5a,5b,6-decachlor
  • 1,3,4-Metheno-2H-cyclobuta[cd]pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-
  • 2,3,3a,4,5,6,7,7a,8,8a-decachloro-3a,4,7,7a-tetrahydro-4,7-methanoinden-1-one
  • 4-metheno-2h-cyclobuta(cd)pentalen-2-one,1,1a,3,3a,4,5,5,5a,5b,6-decachloroctahydro-3
  • Chlorodecone
  • Clordecone
  • Compound 1189
  • compound1189
  • Decachloro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
  • Decachloroketone
  • Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalin-2-one
  • decachlorooctahydro-kepone-2-on
  • keponealcohol